Results 81 to 90 of about 664,017 (364)

Combining laser microdissection and RNA-seq to chart the transcriptional landscape of fungal development

BMC Genomics, 2012
Background During sexual development, filamentous ascomycetes form complex, three-dimensional fruiting bodies for the protection and dispersal of sexual spores.
Teichert Ines, Wolff Gabriele, Kück Ulrich, Nowrousian Minou   +3 more
doaj   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Integrated Transcriptome Analysis Reveals Plant Hormones Jasmonic Acid and Salicylic Acid Coordinate Growth and Defense Responses upon Fungal Infection in Poplar

Biomolecules, 2019
Plants have evolved a sophisticated system to respond to various stresses. Fungal attack or infection is one of the most important biotic stresses for most plants. During the defense response to fungal infection, the plant hormones jasmonic acid (JA) and
Jie Luo, Wenxiu Xia, Pei Cao, Zheng’ang Xiao, Yan Zhang, Meifeng Liu, Chang Zhan, Nian Wang   +7 more
doaj   +1 more source

Current and Future Cornea Chip Models for Advancing Ophthalmic Research and Therapeutics

Advanced Biology, EarlyView.
This review analyzes cornea chip technology as an innovative solution to corneal blindness and tissue scarcity. The examination encompasses recent developments in biomaterial design and fabrication methods replicating corneal architecture, highlighting applications in drug screening and disease modeling while addressing key challenges in mimicking ...
Minju Kim, Kanghoon Choi, Amy Lin, Jungkyu Kim   +3 more
wiley   +1 more source

High hydrostatic pressure harnesses the biosynthesis of secondary metabolites via the regulation of polyketide synthesis genes of hadal sediment-derived fungi

Frontiers in Microbiology, 2023
Deep-sea fungi have evolved extreme environmental adaptation and possess huge biosynthetic potential of bioactive compounds. However, not much is known about the biosynthesis and regulation of secondary metabolites of deep-sea fungi under extreme ...
Ludan Deng, Maosheng Zhong, Yongqi Li, Guangzhao Hu, Changhao Zhang, Qingqing Peng, Zhizhen Zhang, Jiasong Fang, Xi Yu   +8 more
doaj   +1 more source

Influence of gene copy number on self-regulated gene expression [PDF]

, 2016
Using an analytically solvable stochastic model, we study the properties of a simple genetic circuit consisting of multiple copies of an self-regulating gene. We analyse how the variation in gene copy number and the mutations changing the auto-regulation strength affect the steady-state distribution of protein concentration.
arxiv   +1 more source

Chromatin-dependent regulation of secondary metabolite biosynthesis in fungi : is the picture complete? [PDF]

, 2019
Fungal secondary metabolites are small molecules that exhibit diverse biological activities exploited in medicine, industry and agriculture. Their biosynthesis is governed by co-expressed genes that often co-localize in gene clusters.
Collemare, Jérôme, Seidl, Michael F.
core   +2 more sources

Molecular analysis of the early interaction between the grapevine flower and Botrytis cinerea reveals that prompt activation of specific host pathways leads to fungus quiescence [PDF]

, 2017
Grape quality and yield can be impaired by bunch rot, caused by the necrotrophic fungus Botrytis cinerea. Infection often occurs at flowering, and the pathogen stays quiescent until fruit maturity.
Agudelo-Romero, Alkan, Amselem, Asselbergh, Bhuiyan, Birkenbihl, Blanco-Ulate, Boller, Bradley, Brutus, Caffall, Cantu, Choquer, Coertze, Conesa, Costa, Dadakova, Dalmais, De Cremer, Deytieux-Belleau, Du, Eichorn, Elmer, Espino, Favaron, Giannakis, Gilbert, Godfrey, Goetz, Grimplet, Guetsky, Hammerbacher, Hellemans, Höll, Jaillon, Jarvis, Jarvis, Jeandet, Jersch, Kan, Kan, Kan, Keller, Kelloniemi, Kemmerling, Kretschmer, Langcake, Law, Lebel, Lee, Leroch, Leroch, Liao, Liao, Lijavetzky, Liu, Malacarne, Marrs, Martin, McClellan, McNicol, Merz, Mlikota-Gabler, Mohnen, Monteiro, Moretto, Mullins, Nagpala, Nair, Naoumkina, Noda, Padgett, Pezet, Pezet, Prusky, Prusky, Prusky, Puhl, Rieu, Rolke, Rossi, Ruijter, Schouten, Schouten, Schumacher, Schumacher, Shaw, Smith, Smyth, Thimm, Vandesompele, Vannozzi, Velasco, Volodarsky, Vrhovsek, Waite, Weng, Wiermer, Williamson, Williamson, Zhang, Zhang, Zhao   +102 more
core   +1 more source

An ectomycorrhizal fungus alters sensitivity to jasmonate, salicylate, gibberellin, and ethylene in host roots. [PDF]

, 2020
The phytohormones jasmonate, gibberellin, salicylate, and ethylene regulate an interconnected reprogramming network integrating root development with plant responses against microbes.
Amirebrahimi, Mojgan, Barry, Kerrie W, Basso, Veronica, Block, Jonathan, Daguerre, Yohann, Grigoriev, Igor V, Guinet, Frédéric, Kohler, Annegret, Martin, Francis, Miyauchi, Shingo, Na, Hyunsoo, Novák, Ondřej, Singan, Vasanth, Veneault-Fourrey, Claire, Šimura, Jan   +14 more
core   +3 more sources

Gasotransmitters in Modern Medicine: Promises and Challenges in the Use of Porous Crystalline Carriers

Advanced Healthcare Materials, EarlyView.
This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto, Moisés L. Pinto, Christian Serre   +2 more
wiley   +1 more source