Results 201 to 210 of about 282,173 (256)

MicroRNAs in the Mitochondria-Telomere Axis: Novel Insights into Cancer Development and Potential Therapeutic Targets. [PDF]

Genes (Basel)
Cruz-Ramos JA, de la Mora-Jiménez E, Llanes-Cervantes BA, Damián-Mejía MÁ.   +3 more
europepmc   +1 more source

The estrobolome: Estrogen‐metabolizing pathways of the gut microbiome and their relation to breast cancer

International Journal of Cancer, EarlyView.
Abstract Increasing evidence links the gut microbiome to carcinogenesis. Disruptions in estrogen regulation by the estrobolome—gut microbiota with estrogen‐related functions—may promote breast cancer. However, precise information on estrobolome targets and their underlying mechanisms is limited. This review identifies relevant targets for measuring the
Ashley H. Larnder, Amee R. Manges, Rachel A. Murphy   +2 more
wiley   +1 more source

Comprehensive bioinformatics analysis identified HMGB3 as a promising immunotherapy target for glioblastoma multiforme. [PDF]

Discov Oncol
Wang L, Xu P, Li X, Zhang Q.
europepmc   +1 more source

Prospective evaluation of 92 protein biomarkers for early detection of endometrial cancer

International Journal of Cancer, EarlyView.
What's New? In this prospective study, the authors evaluated the discrimination capacity of 92 cancer‐related proteins as potential early detection biomarkers for endometrial cancer using blood samples from two large‐scale European population cohorts (EPIC and Janus).
Victoria Cooley, Renée Turzanski Fortner, Trasias Mukama, Sabine Naudin, Valeria Pala, Laure Dossus, Inger T. Gram, Karina Standahl Olsen, Maria‐Jose Sánchez, Pernilla Israelsson, Naomi Allen, Hilde Langseth, Rudolf Kaaks   +12 more
wiley   +1 more source

Exploring diagnostic m6A regulators in primary open-angle glaucoma: insight from gene signature and possible mechanisms by which key genes function. [PDF]

BMC Med Genomics
Zhang X, Chen J, Zhou X, Zhou D, Liao L, Zhao Y, Wu P, Nie F, Liao Z, Cai Z, Duan X.   +10 more
europepmc   +1 more source

Human sporadic breast carcinoma histotypes driven by the Human Betaretrovirus homologous to Mouse Mammary Tumor Virus

International Journal of Cancer, EarlyView.
What's New? While estrogens, obesity, and alcohol are recognized risk factors for breast cancer, a viral hypothesis has been suggested based on the murine model of Mouse Mammary Tumor Virus (MMTV)‐induced mammary tumors. This study analyzed sequences of the human homolog of MMTV across human breast carcinoma histotypes, detecting the virus in all types
Prospero Civita, Chiara Maria Mazzanti, Francesca Lessi, Caterina Marchiò, Cristian Scatena, Michele Menicagli, Matteo Ghilli, Manuela Roncella, Antonio Giuseppe Naccarato, Anna Sapino, Jacob Hochman, Mauro Pistello, Generoso Bevilacqua   +12 more
wiley   +1 more source

The significance of PAX5 in Merkel cell carcinoma. [PDF]

J Pathol
Chteinberg E, Kolarova J, Vogt J, Macamo A, Bormann F, Kretzmer H, Speel EJ, van den Oord J, Schneider C, Stilgenbauer S, Becker JC, Winnepenninckx V, Biessen E, Zenke M, Kurz AK, Siebert R, Zur Hausen A.   +16 more
europepmc   +1 more source

Histologically verified penile lichen sclerosus—Incidence in Denmark over 26 years and long‐term risk of penile and non‐penile cancer

International Journal of Cancer, EarlyView.
What's New? About half of penile squamous cell carcinomas are causally associated with inflammatory conditions such as lichen sclerosus (LSc), but few large‐scale studies have assessed the risk of penile cancer in men with LSc. Here, the authors conducted a large nationwide study in Denmark to estimate the risk of penile and non‐penile cancer in men ...
Marianne Gardar Stærk, Emma L. Kaderly Rasmussen, Charlotte Gerd Hannibal, Rasmus Hertzum‐Larsen, Louise Baandrup, Susanne K. Kjær   +5 more
wiley   +1 more source

DNA methylation memory of pancreatic acinar-ductal metaplasia transition state altering Kras-downstream PI3K and Rho GTPase signaling in the absence of Kras mutation. [PDF]

Genome Med
Lo EKW, Idrizi A, Tryggvadottir R, Zhou W, Hou W, Ji H, Cahan P, Feinberg AP.   +7 more
europepmc   +1 more source

The influence of microbiome‐derived amino acids metabolites in shaping the glioma immunosuppressive microenvironment

Interdisciplinary Medicine, EarlyView.
Left: The disruption of the balance between carcinogenic bacteria and probiotics mediated by antibiotics, protein, and glucose intake. Middle: The gut microbiota‐derived amino acids, primarily through tryptophan, tyrosine, arginine, and branched‐chain amino acid pathways, regulate glioma development via mechanisms such as AHR activation, metabolic ...
Qianquan Ma, Zhihao Song, Chenlong Yang, Zijin Zhao, Guodong Tang, Jia You, Chong Zeng, Jun Yang, Qing Liu, Haoyu Li, Wei Huang   +10 more
wiley   +1 more source