Results 71 to 80 of about 350,624 (298)
Translational Oncology, 2014 BACKGROUND: Sessile serrated adenomas/polyps (SSA/P) are now recognised precursors of colorectal cancer (CRC) including cancers harbouring somatic BRAF (V600E) mutations.
Maria Caruso +11 more
doaj +1 more source
MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression. [PDF]
PLoS ONE, 2011 Class I MAGE proteins (MAGE I) are normally expressed only in developing germ cells but are aberrantly expressed in many cancers. They have been shown to promote tumor survival, aggressive growth, and chemoresistance but the underlying mechanisms and ...
Tony Z Xiao +5 more
doaj +1 more source
SimpleChrome: Encoding of Combinatorial Effects for Predicting Gene Expression [PDF]
arXiv, 2020 Due to recent breakthroughs in state-of-the-art DNA sequencing technology, genomics data sets have become ubiquitous. The emergence of large-scale data sets provides great opportunities for better understanding of genomics, especially gene regulation.
arxiv
Negative Feedback and Physical Limits of Genes [PDF]
Journal of Theoretical Biology 248:1 (2011) 82-91, 2014 This paper compares the auto-repressed gene to a simple one (a gene without auto-regulation) in terms of response time and output noise under the assumption of fixed metabolic cost. The analysis shows that, in the case of non-vanishing leak expression rate, the negative feedback reduces both the switching on and switching off times of a gene. The noise
arxiv +1 more source
The nuclear-cytoplasmic trafficking of a chromatin-modifyng and remodelling protein (KMT2C), in osteosarcoma [PDF]
, 2018 Osteosarcoma is the most common paediatric primary non-hematopoietic bone tumor; the survival is related to the response to chemotherapy and development of metastases.
Carletti, Raffaella +5 more
core +1 more source
Molecular Oncology, Volume 19, Issue 4, Page 1203-1228, April 2025.MiR‐99a‐5p/miR‐100‐5p (functionally identical) and miR‐125b‐5p microRNAs are downregulated in malignant germ cell tumors (GCTs). Combination replenishment of these microRNAs using mimics resulted in growth inhibition in representative cell lines, with consequent downregulation of target genes involved in cell cycle (confirmed by flow cytometry) and ...
Marta Ferraresso +12 more
wiley +1 more source
Stochastic equations for a self-regulating gene [PDF]
Int. J. Biomath. (2016), 2014 Expression of cellular genes is regulated by binding of transcription factors to their promoter, either activating or inhibiting transcription of a gene. Particularly interesting is the case when the expressed protein regulates its own transcription. In this paper the features of this self-regulating process are investigated.
arxiv +1 more source
Molecular Oncology, Volume 19, Issue 4, Page 1132-1154, April 2025.PIK3CA amplification and PIK3CA mutation enhance ovarian tumorigenicity through an activation of AKT, which phosphorylates YAP at Ser127. This Ser127 phosphorylation leads to the retention of YAP in the cytoplasm and triggers RAC1 activity, promoting cell migration. Additionally, AKT activation increases expression of N‐cadherin, which further enhances
Shibo Zhang +6 more
wiley +1 more source
BMC Cancer, 2007 Background Ovarian cancer (OvCa) most often derives from ovarian surface epithelial (OSE) cells. Several lines of evidence strongly suggest that increased exposure to progesterone (P4) protects women against developing OvCa.
DeLoia Julie A +5 more
doaj +1 more source
The impact of caffeic acid phenethyl ester, chrysin and ethanolic extracts of propolis on PLD1 gene expression in AGS cell line [PDF]
Journal of HerbMed Pharmacology, 2019 Introduction: Up-regulation of phospholipase D (PLD) is functionally related to tumorigenesis and oncogenic signals. Chrysin, caffeic acid phenethyl ester (CAPE) and ethanolic extract of propolis (EEP) are three safe compounds which have been shown to ...
Hamideh Jafari-Ghahfarokhi +3 more
doaj +1 more source