Results 221 to 230 of about 267,816 (318)

Identification of the PsEXP Gene Family and Functional Analysis of <i>PsEXPA4-1</i> During Flower Opening Process in Tree Peony (<i>Paeonia suffruticosa</i>). [PDF]

Genes (Basel)
Ying J, Wang Z, Shen Y, Lin Y, Wang Y, Zhu C, Xu Y, Lin L, Zhu X, Chen X, Wang Q.   +10 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Chloroplasts and Plant Sustainability: Key Roles and Emerging Insights. [PDF]

Int J Mol Sci
Scotti N, Tamburino R.
europepmc   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Basal Differences in the Transcriptional Profiles of Tomato Roots Associated with the Presence/Absence of the Resistance Gene <i>Mi-1</i> and Time-Course Changes During the Compatible and Incompatible Interactions with the Root-Knot Nematode <i>Meloidogyne javanica</i>. [PDF]

Plants (Basel)
Rico A, Ávila A, Emiliozzi M, López-Vidriero I, Franco-Zorrilla JM, Nombela G.   +5 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Comprehensive Analysis of the TLP Gene Family in Pine and Functional Implications in Response to Pine Wood Nematode Infection. [PDF]

Biology (Basel)
An Y, Luo P, Xiao S, Pan C, Zhou H, Wang X, Xiao Y, Guo M.   +7 more
europepmc   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Phytomelatonin as a key regulator of drought stress adaptation: signaling networks, microbial interactions, and biotechnological potential. [PDF]

Front Plant Sci
Dubey N, Shree S, Prakash S, Subramanian V, H P S, Kumar S.   +5 more
europepmc   +1 more source