Results 101 to 110 of about 2,705,095 (358)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

A mouse model for functional dissection of TAB1 O-GlcNAcylation [version 2; peer review: 2 approved]

Wellcome Open Research, 2020
Background: O-GlcNAcylation is a posttranslational modification associated with various physiological and pathophysiological processes including diabetes, cancer, neurodegeneration and inflammation.
Florence Authier, Villő Muha, Daan M.F. van Aalten   +2 more
doaj   +1 more source

Associative memory in gene regulation networks

, 2010
The pattern of gene expression in the phenotype of an organism is determined in part by the dynamical attractors of the organism’s gene regulation network.
Buckley, C. L., Davies, Adam, Mills, Rob, Watson, Richard   +3 more
core  

CYP1B1 promotes tumorigenesis via altered expression of CDC20 and DAPK1 genes in renal cell carcinoma. [PDF]

, 2015
BackgroundCytochrome P450 1B1 (CYP1B1) has been shown to be up-regulated in many types of cancer including renal cell carcinoma (RCC). Several reports have shown that CYP1B1 can influence the regulation of tumor development; however, its role in RCC has ...
Arichi, Naoko, Chang, Inik, Dahiya, Rajvir, Deng, Guoren, Fukuhara, Shinichiro, Hiraki, Miho, Hirata, Hiroshi, Majid, Shahana, Mitsui, Yozo, Shahryari, Varahram, Shiina, Hiroaki, Tanaka, Yuichiro, Wong, Darryn K, Yamamura, Soichiro, Yasumoto, Hiroaki   +14 more
core   +2 more sources

Pharmacological regulation of gene expression [PDF]

Pharmacological Research, 2011
Pharmacological regulation of gene expression was one of the top professional interests of Dr. Costa. He promoted the idea that drugs can improve the endogenous mechanisms of synaptic plasticity by modulating gene expression. In this article I reflect upon Dr.
openaire   +2 more sources

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source

Nascent RNA sequencing reveals mechanisms of gene regulation in the human malaria parasite Plasmodium falciparum. [PDF]

, 2017
Gene expression in Plasmodium falciparum is tightly regulated to ensure successful propagation of the parasite throughout its complex life cycle. The earliest transcriptomics studies in P.
Batugedara, Gayani, Bunnik, Evelien M, Le Roch, Karine G, Lee, Michael, Lu, Xueqing Maggie, Prudhomme, Jacques   +5 more
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Characterisation of the biflavonoid hinokiflavone as a pre-mRNA splicing modulator that inhibits SENP

eLife, 2017
We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule.
Andrea Pawellek, Ursula Ryder, Triin Tammsalu, Lewis J King, Helmi Kreinin, Tony Ly, Ronald T Hay, Richard C Hartley, Angus I Lamond   +8 more
doaj   +1 more source

Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes [PDF]

, 2013
Death domain–associated protein (Daxx) cooperates with X-linked α-thalassaemia retardation syndrome protein (ATRX), a putative member of the sucrose non-fermentable 2 family of ATP-dependent chromatin-remodelling proteins, acting as the core ATPase ...
Andreas Mund, Badens, Baker, Berk, Berube, Blanchette, Carolin Bürck, Chatterjee, Cheng, Chinnadurai, Cuchet-Lourenco, Dallaire, Dellaire, Dobner, Drane, Everett, Flint, Frisch, Gibbons, Glass, Goldberg, Goldberg, Gostissa, Graham, Groitl, Gunther, Hancock, Harlow, Hassan, Hollenbach, Ishov, Ishov, Jin, Kahyo, Kindsmuller, Kindsmuller, Kindsmüller, Ko, Komatsu, Kosulin, Lewis, Lewis, Li, Lukashchuk, Lukashchuk, Mandy Glass, Marton, Matsumoto, Maul, McFarlane, Michaelson, Mitsudomi, Mund, Nevels, Nevins, Nevins, Niforou, Okuwaki, Orazio, Parks, Pelka, Peter Groitl, Peter Wimmer, Placek, Querido, Roger D. Everett, Ross, Rubenwolf, Sabrina Schreiner, Salomoni, Sarah Kinkley, Sarnow, Schreiner, Schreiner, Schreiner, Shenk, Si, Song, Stracker, Takahashi, Tang, Thomas Dobner, Torii, Täuber, Täuber, Ullman, White, Williams, Wilson, Wong, Wong, Xu, Xue   +92 more
core   +1 more source