Long-Term Memory Formation in Drosophila Depends on the 3′UTR of CPEB Gene orb2
Activation of local translation in neurites in response to stimulation is an important step in the formation of long-term memory (LTM). CPEB proteins are a family of translation factors involved in LTM formation. The Drosophila CPEB protein Orb2 plays an
Eugene N. Kozlov +10 more
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Consequences of early life stress on genomic landscape of H3K4me3 in prefrontal cortex of adult mice
Background Maternal separation models in rodents are widely used to establish molecular mechanisms underlying prolonged effects of early life adversity on neurobiological and behavioral outcomes in adulthood.
Nikita I. Ershov +5 more
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Nongenomic regulation of gene expression
Purpose of review The purpose of this review is to highlight the recent advances in epigenetic regulation and chromatin biology for a better understanding of gene regulation related to human disease. Recent findings Alterations to chromatin influence genomic function, including gene
Iglesias-Platas I, Monk D
openaire +3 more sources
Proteomic analysis of the response to cell cycle arrests in human myeloid leukemia cells
Previously, we analyzed protein abundance changes across a ‘minimally perturbed’ cell cycle by using centrifugal elutriation to differentially enrich distinct cell cycle phases in human NB4 cells (Ly et al., 2014).
Tony Ly, Aki Endo, Angus I Lamond
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Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB
Cancer is often characterised by the presence of hypoxia and inflammation. Paramount to the mechanisms controlling cellular responses under such stress stimuli, are the transcription factor families of Hypoxia Inducible Factor (HIF) and Nuclear Factor of
Laura D’Ignazio +2 more
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Regulation of Murine Class I Genes by Interferons is Controlled by Regions Located Both 5' and 3' to the Transcription Initiation Site [PDF]
Interferons regulate the expression of a large number of mammalian genes, including the major histocompatibility antigen genes. To investigate the mechanisms involved in interferon action, we have analyzed the ability of murine H-2Ld and H-2Dd DNA ...
Hood, Leroy +2 more
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Control of human adenovirus type 5 gene expression by cellular Daxx/ATRX chromatin-associated complexes [PDF]
Death domain–associated protein (Daxx) cooperates with X-linked α-thalassaemia retardation syndrome protein (ATRX), a putative member of the sucrose non-fermentable 2 family of ATP-dependent chromatin-remodelling proteins, acting as the core ATPase ...
Andreas Mund +92 more
core +1 more source
TcZC3HTTP, a regulatory element that contributes to Trypanosoma cruzi cell proliferation
Post-transcriptional regulation of gene expression is a critical process for adapting to and surviving Trypanosoma cruzi, a parasite with a complex life cycle.
Bruno Accioly Alves Romagnoli +5 more
doaj +1 more source
Molecular Basis of the Function of Transcriptional Enhancers
Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process ...
Airat N. Ibragimov +2 more
doaj +1 more source
Balancing noise and plasticity in gene expression [PDF]
Coupling the control of expression stochasticity (noise) with the capacity to expression change (plasticity) can constrain gene function and limit adaptation. Which factors contribute then to modulate this coupling?
Djordje Bajic, Juan F. Poyatos
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