Results 171 to 180 of about 13,199,223 (392)

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Meat quality of Italian Simmental young bulls as affected by the genes frequency of Montbeliarde origin

, 2003
Edi Piasentier, R. Valusso, Luisa Antonella Volpelli, Angela Sepulcri, Paola Pittia, S. Failla   +5 more
openalex   +2 more sources

Age dependence of the gene frequency of alpha-thalassemia in sickle cell anemia in Cuba [letter] [PDF]

, 1996
Gustavo Aroca, Ana Veruska Cruz da Silva, Eva Svarch, Enrique Espinosa, RL Nagel   +4 more
openalex   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

The Spectrum and Carrier Frequencies of Common Pathogenic Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations in Men from the General Population: The Role of Ethnicity [PDF]

Л. В. Осадчук, Mikhail Ivanov, E. G. Komova, А. В. Осадчук   +3 more
openalex   +1 more source

HIGHER CTX-M, TEM, AND SHV EXTENDED-SPECTRUM BETA-LACTAMASE PLASMID GENE COMBINATION FREQUENCY IN ESBL PRODUCING KLEBSIELLA PNEUMONIAE COMPARED WITH ESBL PRODUCING ESCHERICHIA COLI [PDF]

, 2016
Vita Skuja, Katrīna Pekarska, Aleksejs Derovs, Ludmila Vīksna, Linda Gailīte, Inga Kempa, Una Caune, Dace Rudzīte, Aivars Lejnieks, Angelika Krūmiņa   +9 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Incidence, prevalence, and gene frequency studies of chronic childhood spinal muscular atrophy.

Journal of Medical Genetics, 1978
J. Pearn
semanticscholar   +1 more source

Distribution of Phenotypes and Gene Frequencies of Six Red Cell Enzymes in the District of Tohoku, Northern Part of Japan

, 1971
Shoji Harada, Suguru Akaishi, Toshiyuhi KUDO, Keiichi Omoto   +3 more
openalex   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source