Results 181 to 190 of about 11,790,132 (329)

Frequency and duration of sensory flicker control transcriptional profiles in 5xFAD mice. [PDF]

APL Bioeng
Bitarafan S, Pybus AF, Rivera Moctezuma FG, Adibi M, Franklin TC, Singer AC, Wood LB.   +6 more
europepmc   +1 more source

Detection of a high frequency RsaI polymorphism in the human pro alpha 2(I) collagen gene which is linked to an autosomal dominant form of osteogenesis imperfecta. [PDF]

, 1985
Anne Grobler, Gillian A. Wallis, Diana K. Brebner, Peter Beighton, A J Bester, Christopher G. Mathew   +5 more
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

The Spectrum and Carrier Frequencies of Common Pathogenic Cystic Fibrosis Transmembrane Conductance Regulator Gene Mutations in Men from the General Population: The Role of Ethnicity. [PDF]

Int J Mol Sci
Osadchuk L, Ivanov M, Komova E, Osadchuk A.   +3 more
europepmc   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Homology-arm length of donor DNA affects the impact of Msh2 loss on homologous recombination-mediated gene targeting. [PDF]

Proc Natl Acad Sci U S A
Saito S, Suzuki T, Nohmi T, Adachi N.
europepmc   +1 more source

Homologous recombination of SV4O DNA in COS7 cells occurs with high frequency m a gene dose independent fashion [PDF]

, 1988
W Rommerskirch, Ingeborg Graeber, M. Grässmann, Adolf Grássmann   +3 more
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Redistribution of Gene Frequency and Changes of Genetic Variation Following a Bottleneck in Population Size

Genetics, 2004
Xu‐Sheng Zhang, Jinliang Wang, W. G. Hill   +2 more
semanticscholar   +1 more source

Frequency of chlorophyll-deficient and other detrimental genes in Japanese populations of buckwheat, Fagopyrum esculentum Moench.

, 1979
Ohmi Ohnishi
openalex   +2 more sources