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Unraveling the evolutionary origin of the P5CS gene: a story of gene fusion and horizontal transfer [PDF]

Frontiers in Molecular Biosciences
The accumulation of proline in response to the most diverse types of stress is a widespread defense mechanism. In prokaryotes, fungi, and certain unicellular eukaryotes (green algae), the first two reactions of proline biosynthesis occur through two ...
João Pedro Carmo Filgueiras, Marcel Zámocký, Andreia Carina Turchetto-Zolet   +2 more
doaj   +2 more sources

XAC4296 Is a Multifunctional and Exclusive Xanthomonadaceae Gene Containing a Fusion of Lytic Transglycosylase and Epimerase Domains

Microorganisms, 2022
Microorganisms have a limited and highly adaptable repertoire of genes capable of encoding proteins containing single or variable multidomains. The phytopathogenic bacteria Xanthomonas citri subsp. citri (X.
Amanda C. P. de Oliveira, Rafael M. Ferreira, Maria Inês T. Ferro, Jesus A. Ferro, Caio Zamuner, Henrique Ferreira, Alessandro M. Varani   +6 more
doaj   +1 more source

Tropomyosin receptor kinase B (TrkB) signalling: targeted therapy in neurogenic tumours

The Journal of Pathology: Clinical Research, 2023
Tropomyosin receptor kinase B (TrkB), a transmembrane receptor protein, has been found to play a pivotal role in neural development. This protein is encoded by the neurotrophic receptor tyrosine kinase 2 (NTRK2) gene, and its abnormal activation caused ...
Yuehua Li, Chengjiang Wei, Wei Wang, Qingfeng Li, Zhi‐Chao Wang   +4 more
doaj   +1 more source

Genomic Features of Solid Tumor Patients Harboring ALK/ROS1/NTRK Gene Fusions

Frontiers in Oncology, 2022
The fusions of receptor tyrosine kinase (RTK) involving anaplastic lymphoma kinase (ALK), c-ros oncogene 1 (ROS1), and neurotrophic receptor tyrosine kinase (NTRK) represent the potential targets of therapeutic intervention for various types of solid ...
Yinghuan Dai, Ping Liu, Wenlong He, Lizhen Yang, Yang Ni, Yang Ni, Xuejiao Ma, Xuejiao Ma, Furong Du, Furong Du, Chao Song, Chao Song, Yang Liu, Yi Sun   +13 more
doaj   +1 more source

Chimeric RNA Design Principles for RNA-Mediated Gene Fusion

Cells, 2022
One common genetic alteration in cancer is gene fusion resulting from chromosomal translocations. The mechanisms that create such oncogenic fusion genes are not well understood.
Sachin Kumar Gupta, Laising Yen
doaj   +1 more source

Development of a new candidate vaccine against piglet diarrhea caused by Escherichia coli

Open Life Sciences, 2023
Enterotoxigenic Escherichia coli (ETEC) is an important type of pathogenic bacteria that causes diarrhea in humans and young livestock. The pathogen has a high morbidity and mortality rate, resulting in significant economic losses in the pig industry. To
Xu Chongli, Fu Fengyang, She Yuhan, Yang Danni, Peng Kun, Lin Yimin, Xu ChongBo   +6 more
doaj   +1 more source

Prospective evaluation of the role of imaging techniques and TMPRSS2:ERG mutation for the diagnosis of clinically significant prostate cancer

Frontiers in Oncology, 2022
ObjectivesTo test the hypothesis of a relationship between a specific genetic lesion (T2:ERG) and imaging scores, such as PI-RADS and PRI-MUS, and to test the effectiveness of these parameters for the diagnosis of prostate cancer (PCa) and clinically ...
Massimo Lazzeri, Vittorio Fasulo, Vittorio Fasulo, Giovanni Lughezzani, Giovanni Lughezzani, Alessio Benetti, Giulia Soldà, Giulia Soldà, Rosanna Asselta, Rosanna Asselta, Ilaria De Simone, Ilaria De Simone, Marco Paciotti, Marco Paciotti, Pier Paolo Avolio, Pier Paolo Avolio, Roberto Contieri, Roberto Contieri, Cesare Saitta, Cesare Saitta, Alberto Saita, Rodolfo Hurle, Giorgio Guazzoni, Giorgio Guazzoni, Nicolò Maria Buffi, Nicolò Maria Buffi, Paolo Casale   +26 more
doaj   +1 more source

Integrative analysis of synovial sarcoma transcriptome reveals different types of transcriptomic changes

Frontiers in Genetics, 2022
Background: Synovial sarcoma (SS) is a rare and aggressive cancer that can come from distinct soft tissue types including muscle and ligaments. However, the transcriptomic landscape of SS is still poorly understood.
Zhengwang Sun, Mengchen Yin, Yi Ding, Zixu Zhu, Yangbai Sun, Kun Li, Wangjun Yan   +6 more
doaj   +1 more source

Recurrent De Novo NAHR Reciprocal Duplications in the ATAD3 Gene Cluster Cause a Neurogenetic Trait with Perturbed Cholesterol and Mitochondrial Metabolism. [PDF]

, 2020
Recent studies have identified both recessive and dominant forms of mitochondrial disease that result from ATAD3A variants. The recessive form includes subjects with biallelic deletions mediated by non-allelic homologous recombination.
Armstrong, C, Baple, E, Baptista, J, Caswell, R, Cunningham, MH, Dean, J, Durigon, R, Durlacher-Betzer, K, Ellard, S, Fernandez Pelayo, U, Grochowski, CM, Gunning, AC, Harel, T, Holt, IJ, Homfray, T, Jones, AWE, Lahiri, N, Lupski, JR, Misra, VK, Muñoz Oreja, M, Parrish, A, Scurr, I, Spinazzola, A, Stals, KL, Strucinska, K, Taylor, RW, Tysoe, C, Wright, CF, Yoon, WH   +28 more
core   +3 more sources

Case Report: Identification of Multiple TERT and FGFR2 Gene Fusions in a Pineal Region Glioblastoma Case

Frontiers in Oncology, 2021
As an oncogenic somatic variant, telomerase reverse transcriptase promoter (TERTp) mutations are frequently observed in adult glioblastoma (GBM). Alternatively, we report the first case of glioblastoma with TERT amplification accompanied by multiple TERT
Xing Guo, Xing Guo, Teng Chen, Teng Chen, Shiming Chen, Chao Song, Dezhi Shan, Dezhi Shan, Shujun Xu, Shujun Xu, Shuo Xu, Shuo Xu   +11 more
doaj   +1 more source