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2021
Fusion gene is a hybrid form of two distinct genes resulting in broad spectrum of downstream pathway alterations. Gene fusion events are mostly from genomic rearrangements though diverse mechanisms have now been identified from in-depth analyses of next generation sequencing data.
Jisun, Kim, Wonshik, Han
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Fusion gene is a hybrid form of two distinct genes resulting in broad spectrum of downstream pathway alterations. Gene fusion events are mostly from genomic rearrangements though diverse mechanisms have now been identified from in-depth analyses of next generation sequencing data.
Jisun, Kim, Wonshik, Han
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Targeting gene fusions in glioma
Current Opinion in Neurology, 2021Purpose of review Glioma represents of variety of brain malignancies, the majority of which confer a poor prognosis despite treatment. With the widespread use of next-generation sequencing, gene fusions are being found in greater numbers.
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Gene fusion techniques cloning vectors for manipulating lacZ gene fusions
Gene Analysis Techniques, 1984Abstract A simple vector system for cloning gene fusions of lacZ is described. We apply one of these new vectors to the cloning and transcriptional analysis of the promoter region of the ompF gene of Escherichia coli .
Berman, M. L. +6 more
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Gene Fusions in Thyroid Cancer
Thyroid, 2018Gene fusions are known in many cancers as driver or passenger mutations. They play an important role in both the etiology and pathogenesis of cancer and are considered as potential diagnostic and prognostic markers and possible therapeutic targets.
Valentina D, Yakushina +2 more
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Gene therapy for spinal fusion
The Spine Journal, 2005Spinal fusion will continue to be an important part of the surgical treatment of spinal pathology for the foreseeable future. Traditional challenges to successful spinal fusion surgery include autograft donor site morbidity and pseudoarthrosis. Recent advances in the understanding of the biology of bone formation have allowed the development of ...
Frank M, Phillips +3 more
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Gene Fusion Discovery with INTEGRATE
2019Next-generation sequencing (NGS) has become the primary technology for discovering gene fusions. Decreasing NGS costs have resulted in a growing quantity of patients with whole transcriptome sequencing (RNA-seq) and whole genome sequencing (WGS) data.
Jin, Zhang, Christopher A, Maher
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Seminars in Cancer Biology, 1999
Tumor development in different cell types and tissue locations involves many pathways, distinct genes and exogenous factors. Tumor type-specific chromosome rearrangements resulting in fusion genes or promoter swapping are believed to be involved in the early development of many tumor types.
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Tumor development in different cell types and tissue locations involves many pathways, distinct genes and exogenous factors. Tumor type-specific chromosome rearrangements resulting in fusion genes or promoter swapping are believed to be involved in the early development of many tumor types.
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Genome evolution. Gene fusion versus gene fission.
Trends in genetics : TIG, 2000Item does not contain ...
Snel, B., Bork, P., Huynen, M.A.
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Irradiation and Fusion Gene Transfer
2003The fusion of human and rodent somatic cells is usually followed by the spontaneous loss of human chromosomes from the hybrid cells (1). The correlation between the presence of a human chromosome retained in the hybrid cell and the presence of a human phenotypic trait is the basis of human gene mapping by somatic cell genetics (2).
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Cancer epigenetics in clinical practice
Ca-A Cancer Journal for Clinicians, 2023Veronica Davalos, Manel Esteller
exaly