Results 31 to 40 of about 1,003,870 (312)
The Urea Carboxylase and Allophanate Hydrolase Activities of Urea Amidolyase Are Functionally Independent [PDF]
, 2016 Urea amidolyase (UAL) is a multifunctional biotin-dependent enzyme that contributes to both bacterial and fungal pathogenicity by catalyzing the ATP-dependent cleavage of urea into ammonia and CO2.
Bahler +48 more
core +2 more sources
INTEGRATE-Neo: A pipeline for personalized gene fusion neoantigen discovery [PDF]
, 2016 Motivation While high-throughput sequencing (HTS) has been used successfully to discover tumor-specific mutant peptides (neoantigens) from somatic missense mutations, the field currently lacks a method for identifying which gene fusions
Maher, Christopher A +2 more
core +2 more sources
Unscrambling cancer genomes via integrated analysis of structural variation and copy number
Cell Genomics, 2022 Summary: Complex somatic genomic rearrangements and copy number alterations are hallmarks of nearly all cancers. We have developed an algorithm, LINX, to aid interpretation of structural variant and copy number data derived from short-read, whole-genome ...
Charles Shale +7 more
doaj +1 more source
Insertional gene fusion technology
FEBS Letters, 1999 The classical ‘end to end’ gene fusion technique has widely been used for monitoring gene expression, biological screening and purification of recombinant proteins. Recent progress with the ‘insertional’ gene fusion approach, on the other hand, has demonstrated that this technique can be utilized for membrane protein topology analysis, display of ...
Doi, Nobuhide, Yanagawa, Hiroshi
openaire +2 more sources
Massive NGS data analysis reveals hundreds of potential novel gene fusions in human cell lines [PDF]
, 2018 Background: Gene fusions derive from chromosomal rearrangements and the resulting chimeric transcripts are often endowed with oncogenic potential. Furthermore, they serve as diagnostic tools for the clinical classification of cancer subgroups with ...
Bolis, Marco +7 more
core +1 more source
miRNA-convergent gene fusions [PDF]
Molecular & Cellular Oncology, 2017 In a recent study published in Nature Communications, we showed that intron-encoded microRNA genes (miRNA) are frequent partners of fusion genes in the cancer genome. Analyzed from a functional rather than structural perspective, these rearrangements represent a new class of fusions we called "miRNA-convergent fusions".
openaire +3 more sources
FusionGDB: fusion gene annotation DataBase [PDF]
Nucleic Acids Research, 2018 Gene fusion is one of the hallmarks of cancer genome via chromosomal rearrangement initiated by DNA double-strand breakage. To date, many fusion genes (FGs) have been established as important biomarkers and therapeutic targets in multiple cancer types.
Kim, Pora, Zhou, Xiaobo
openaire +2 more sources
Expression in Escherichia coli of a cloned DNA sequence encoding the pre-S2 region of hepatitis B virus [PDF]
, 1985 A DNA sequence encoding the entire pre-S2 region (amino acids 120-174; serotype ayw) of human hepatitis B virus envelope protein has been inserted into the lacZ gene of the plasmid pSKS105 yielding a recombinant, pWS3.
Acs, George +7 more
core +1 more source
Frontiers in OncologyRisk stratification and molecular targeting have been key to increasing cure rates for pediatric cancers in high-income countries. In contrast, precise diagnosis in low-resource settings is hindered by insufficient pathology infrastructure.
Julie M. Gastier-Foster +24 more
doaj +1 more source
SS18-SSX Rearrangement in Synovial Sarcoma Using Fluorescent in Situ Hybridization: A Report from an Iranian Population and Literature Review [PDF]
Middle East Journal of Cancer, 2020 Background: Synovial sarcoma is an aggressive soft tissue sarcoma. It has a wide spectrum of histopathologic patterns and uncertain immunohistochemistry, rendering it a diagnostic challenge.
Akbar Safaei +4 more
doaj +1 more source