Results 71 to 80 of about 1,003,870 (312)

Profiling Receptor Tyrosine Kinase Fusions in Chinese Breast Cancers

Frontiers in Oncology, 2021
BackgroundReceptor tyrosine kinases (RTKs) are a class of tyrosine kinases that regulate cell-to-cell communication and control a variety of complex biological functions.
Zhonghua Tao, Zhonghua Tao, Jianxia Liu, Ting Li, Ting Li, Hong Xu, Kai Chen, Jian Zhang, Jian Zhang, Hao Zhou, Jie Sun, Jinming Han, Zhaoji Guo, Hua Yang, Wen-Ming Cao, Xichun Hu, Xichun Hu   +16 more
doaj   +1 more source

Bayesian correlated clustering to integrate multiple datasets [PDF]

, 2012
Motivation: The integration of multiple datasets remains a key challenge in systems biology and genomic medicine. Modern high-throughput technologies generate a broad array of different data types, providing distinct – but often complementary ...
Balasubramanian, Barash, Brock, Carlson, Cheng, Cherry, Cho, Cooke, Datta, David L. Wild, Dempster, Friedman, Fritsch, Granovskaia, Green, Harbison, Hubert, Huttenhower, Ideker, Ishwaran, Jackson, Jackson, Jansen, Jim E. Griffin, Kirk, Lee, Liu, Liu, Lockhart, Mistry, Myers, Myers, Neal, Neal, Nieto-Barajas, Paul Kirk, Puig, Rand, Rasmussen, Rasmussen, Reiss, Rhodes, Richard S. Savage, Rigaut, Rogers, Rogers, Rousseau, Santisteban, Savage, Schena, Shen, Solomon, Stark, Suchard, Troyanskaya, Wei, Wong, Yeung, Yuan, Zoubin Ghahramani   +59 more
core   +2 more sources

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

A Pancancer Analysis of the Expression Landscape and Clinical Relevance of Fibroblast Growth Factor Receptor 2 in Human Cancers

Frontiers in Oncology, 2021
Background: Fibroblast growth factor receptor 2 (FGFR2) is frequently altered in tumors and one of the top therapeutic targets in cholangiocarcinoma (CHOL) with FGFR2 fusions. Although there have been several studies on individual tumors, a comprehensive
Juanni Li, Kuan Hu, Jinzhou Huang, Lei Zhou, Yuanliang Yan, Yuanliang Yan, Zhijie Xu   +6 more
doaj   +1 more source

Non-Canonical Thinking for Targeting ALK-Fusion Onco-Proteins in Lung Cancer. [PDF]

, 2017
Anaplastic lymphoma kinase (ALK) gene rearrangements have been identified in lung cancer at 3-7% frequency, thus representing an important subset of genetic lesions that drive oncogenesis in this disease. Despite the availability of multiple FDA-approved
Bivona, Trever G, Haderk, Franziska, Wu, Wei   +2 more
core   +3 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Solitary fibrous tumour of the genitourinary tract: a clinicopathological study of 11 cases and their association with the NAB2-STAT6 fusion gene [PDF]

, 2016
Aims To characterise clinicopathological features and clinical outcomes of the genitourinary tract solitary fibrous tumours, incorporating NAB2-STAT6 gene fusion status. Methods The presence of the molecular hallmark NAB2-STAT6 gene fusion and for the
Baldridge, Lee Ann, Chen, Shaoxiong, Cheng, Liang, Eble, John N., Emerson, Robert E., Grignon, David J., Kouba, Erik, Linos, Konstantinos, Lopez-Beltran, Antonio, MacLennan, Gregory T., Monn, M. Francesca, Montironi, Rodolfo, Osunkoya, Adeboye O., Simper, Novae B., Tran, Thu, Wang, Lisha, Wang, Mingsheng, Williamson, Sean R., Zhang, Shaobo   +18 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Very Rare Complementation between Mitochondria Carrying Different Mitochondrial DNA Mutations Points to Intrinsic Genetic Autonomy of the Organelles in Cultured Human Cells [PDF]

, 2000
In the present work, a large scale investigation was done regarding the capacity of cultured human cell lines (carrying in homoplasmic form either the mitochondrial tRNALys A8344G mutation associated with the myoclonic epilepsy and ragged red fiber ...
Attardi, Giuseppe, Bayona-Bafaluy, M. Pilar, Cabezas-Herrera, Juan, Enríquez, José A.   +3 more
core   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source