Results 91 to 100 of about 6,900,738 (371)

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Functional Significance of Isoform Diversification in the Protocadherin Gamma Gene Cluster [PDF]

Neuron, 2012
The mammalian Protocadherin (Pcdh) alpha, beta, and gamma gene clusters encode a large family of cadherin-like transmembrane proteins that are differentially expressed in individual neurons. The 22 isoforms of the Pcdhg gene cluster are diversified into A-, B-, and C-types, and the C-type isoforms differ from all other clustered Pcdhs in sequence and ...
Chen, Weisheng V., Alvarez, Francisco J., Lefebvre, Julie L., Friedman, Brad, Nwakeze, Chiamaka, Geiman, Eric, Smith, Courtney, Thu, Chan Aye, Tapia, Juan Carlos, Tasic, Bosiljka, Sanes, Joshua R., Maniatis, Tom   +11 more
openaire   +4 more sources

Comparison of Affymetrix Gene Array with the Exon Array shows potential application for detection of transcript isoform variation

BMC Genomics, 2009
Background The emergence of isoform-sensitive microarrays has helped fuel in-depth studies of the human transcriptome. The Affymetrix GeneChip Human Exon 1.0 ST Array (Exon Array) has been previously shown to be effective in profiling gene expression at ...
Coulombe-Huntington Jasmin, Ha Kevin CH, Majewski Jacek   +2 more
doaj   +1 more source

Using machine learning to detect the differential usage of novel gene isoforms

BMC Bioinformatics, 2022
Background Differential isoform usage is an important driver of inter-individual phenotypic diversity and is linked to various diseases and traits. However, accurately detecting the differential usage of different gene transcripts between groups can be ...
Xiaopu Zhang, Musa A. Hassan, James G. D. Prendergast   +2 more
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells [PDF]

, 2012
Background: Although GATA1 is one of the most extensively studied haematopoietic transcription factors little is currently known about the physiological functions of its naturally occurring isoforms GATA1s and GATA1FL in humans—particularly whether the ...
A Quintas-Cardama, A Zipursky, AG Muntean, AG Muntean, Brenda Gibson, C Halsey, C Kuhl, Christina Halsey, CS McKimmie, Derek Gilchrist, Gerard Graham, H Sakamoto, I Matsumura, J Wechsler, JD Crispino, JP Bourquin, K Georgopoulos, KA Alford, L Gutierrez, LC Andersson, LM Hollanda, M Ritter, Marie Docherty, ME Greene, Mhairi McNeill, Michelle Le Brocq, N Shimokawa, N Suzuki, N Ueki, O Tunstall-Pedoe, PA Tetteroo, R Alitalo, R Calligaris, R Ferreira, RA Shivdasani, S Pearson-White, S Teichler, T Nomura, Y Ge, Z Li   +39 more
core   +2 more sources

Isoform level expression profiles provide better cancer signatures than gene level expression profiles

Genome Medicine, 2013
BackgroundThe majority of mammalian genes generate multiple transcript variants and protein isoforms through alternative transcription and/or alternative splicing, and the dynamic changes at the transcript/isoform level between non-oncogenic and cancer ...
Zhongfa Zhang, Sharmistha Pal, Y. Bi, J. Tchou, R. Davuluri   +4 more
semanticscholar   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

The evolutionarily conserved avianAiolos gene encodes alternative isoforms [PDF]

European Journal of Immunology, 1999
Aiolos is an Ikaros-related lymphoid regulatory protein involved in B cell development and function. To evaluate the role of Aiolos in avian B lymphopoiesis, we have cloned and characterized the first non-mammalian Aiolos ortholog in the avian. In sharp contrast to the avian Ikaros, expressed already at the multipotential stage and prior to the ...
A Mansikka, Olli Lassila, Jussi Liippo
openaire   +3 more sources

Differential expression of metallothionein isoforms in terrestrial snail embryos reflects early life stage adaptation to metal stress.

PLoS ONE, 2015
The aim of this study was to analyze the expression of three metallothionein (MT) isoform genes (CdMT, CuMT and Cd/CuMT), already known from adults, in the Early Life Stage (ELS) of Cantareus aspersus. This was accomplished by detection of the MT isoform-
Pierre-Emmanuel Baurand, Veronika Pedrini-Martha, Annette de Vaufleury, Michael Niederwanger, Nicolas Capelli, Renaud Scheifler, Reinhard Dallinger   +6 more
doaj   +1 more source