Results 111 to 120 of about 6,900,738 (371)
Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase
, 2005 Integrating biological information from different sources to understand cellular processes is an important problem in systems biology. We use data from mRNA expression arrays and chemical kinetics to formulate a metabolic model relevant to K562 ...
Akesson +47 more
core +1 more source
BMC Systems Biology, 2013 BackgroundIdentification of expression alternations between early and late stage cancers is helpful for understanding cancer development and progression. Much research has been done focusing on stage-dependent gene expression profiles.
Qi Liu, Shilin Zhao, P. Su, Shyr Yu
semanticscholar +1 more source
Molecular Oncology, EarlyView.Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit +19 more
wiley +1 more source
EGFR isoforms and gene regulation in human endometrial cancer cells [PDF]
Molecular Cancer, 2010 AbstractBackgroundEpidermal growth factor (EGF) and its receptor (EGFR) constitute a principal growth-promoting pathway in endometrial cancer cells. Pre-clinical studies were undertaken to compare the expression of EGFR isoforms and the downstream effects of activating or blocking EGFR function in Ishikawa H cells, derived from a moderately ...
Marilee Morgan +6 more
openaire +4 more sources
Paraoxonase 2 protein is spatially expressed in the human placenta and selectively reduced in labour [PDF]
, 2014 Humans parturition involves interaction of hormonal, neurological, mechanical stretch and inflammatory pathways and the placenta plays a crucial role.
A Abdulsid +32 more
core +3 more sources
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Identification and characterization of Dlc1 isoforms in the mouse and study of the biological function of a single gene trapped isoform [PDF]
BMC Biology, 2010 Abstract Background The Dlc1 (deleted in liver cancer 1) tumour suppressor gene codes for a RhoGTPase activating protein that is found inactivated in many tumour types. Several transcriptional isoforms have been described but the functional significance and tissue distribution of each form is presently poorly ...
Geoffrey G. Hicks +6 more
openaire +4 more sources
Cell Reports, 2019 Summary: Alternative translation is an important mechanism of post-transcriptional gene regulation leading to the expression of different protein isoforms originating from the same mRNA.
Philipp Trulley +11 more
doaj
Influence of Temperature, Hypercapnia, and Development on the Relative Expression of Different Hemocyanin Isoforms in the Common Cuttlefish Sepia officinalis [PDF]
, 2012 The cuttlefish Sepia officinalis expresses several hemocyanin isoforms with potentially different pH optima, indicating their reliance on efficient pH regulation in the blood.
Gutowska, Magdalena A. +7 more
core +1 more source
SURVIV for survival analysis of mRNA isoform variation
Nature Communications, 2016 The rapid accumulation of clinical RNA-seq data sets has provided the opportunity to associate mRNA isoform variations to clinical outcomes. Here we report a statistical method SURVIV (Survival analysis of mRNA Isoform Variation), designed for ...
Shihao Shen +4 more
semanticscholar +1 more source