Results 121 to 130 of about 7,252,476 (351)
C/EBPβ-1 promotes transformation and chemoresistance in Ewing sarcoma cells. [PDF]
, 2017 CEBPB copy number gain in Ewing sarcoma was previously shown to be associated with worse clinical outcome compared to tumors with normal CEBPB copy number, although the mechanism was not characterized.
Abegglen, Lisa M +12 more
core +1 more source
The Actin Gene Family: Function Follows Isoform
Cytoskeleton, 2010 Although actin is often thought of as a single protein, in mammals it actually consists of six different isoforms encoded by separate genes. Each isoform is remarkably similar to every other isoform, with only slight variations in amino acid sequence ...
B. Perrin, J. Ervasti
semanticscholar +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Homologous expression and purification of human HAX‐1 for structural studies
FEBS Open Bio, EarlyView.This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley +1 more source
Hit and run versus long-term activation of PARP-1 by its different domains fine-tunes nuclear processes. [PDF]
, 2019 Poly(ADP-ribose) polymerase 1 (PARP-1) is a multidomain multifunctional nuclear enzyme involved in the regulation of the chromatin structure and transcription.
Ampofo, Michelle +13 more
core +1 more source
Detecting differential usage of exons from RNA-Seq data [PDF]
, 2012 RNA-Seq is a powerful tool for the study of alternative splicing and other forms of alternative isoform expression. Understanding the regulation of these processes requires comparisons between treatments, tissues or conditions.
Alejandro Reyes +2 more
core +3 more sources
ISOexpresso: a web-based platform for isoform-level expression analysis in human cancer
BMC Genomics, 2016 Alternative splicing events that result in the production of multiple gene isoforms reveals important molecular mechanisms. Gene isoforms are often differentially expressed across organs and tissues, developmental stages, and disease conditions ...
In Seok Yang +3 more
semanticscholar +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Uncovering the dynamics and consequences of RNA isoform changes during neuronal differentiation
Molecular Systems BiologyStatic gene expression programs have been extensively characterized in stem cells and mature human cells. However, the dynamics of RNA isoform changes upon cell-state-transitions during cell differentiation, the determinants and functional consequences ...
Jelena Ulicevic +10 more
doaj +1 more source
Journal of Biological Chemistry, 2011 Krüppel-like factor 4 (KLF4) is a transcription factor that plays an important role in cell differentiation, proliferation, and survival, especially in the context of cancers. This study revealed that KLF4 activates glycolytic metabolism in breast cancer
Jong-Seok Moon +7 more
semanticscholar +1 more source