Results 141 to 150 of about 6,900,738 (371)

Single‐cell polyadenylation site mapping reveals 3′ isoform choice variability

Molecular Systems Biology, 2015
Cell‐to‐cell variability in gene expression is important for many processes in biology, including embryonic development and stem cell homeostasis. While heterogeneity of gene expression levels has been extensively studied, less attention has been paid to
Lars Velten, Simon Anders, Aleksandra Pekowska, Aino I Järvelin, Wolfgang Huber, Vicent Pelechano, Lars M Steinmetz   +6 more
doaj   +1 more source

Differential expression of a new isoform of DLG2 in renal oncocytoma

BMC Cancer, 2006
Background Renal oncocytoma, a benign tumour of the kidney, may pose a differential diagnostic problem due to overlapping phenotype with chromophobe renal cell carcinoma or other types of renal cell tumours. Therefore, identification of molecular markers
Kovacs Gyula, Stupar Zorica, Zubakov Dmitry   +2 more
doaj   +1 more source

FreePSI: an alignment-free approach to estimating exon-inclusion ratios without a reference transcriptome. [PDF]

, 2017
Alternative splicing plays an important role in many cellular processes of eukaryotic organisms. The exon-inclusion ratio, also known as percent spliced in, is often regarded as one of the most effective measures of alternative splicing events.
Jiang, Tao, Ma, Shining, Wang, Dongfang, Zeng, Jianyang, Zhou, Jianyu   +4 more
core   +1 more source

IIIDB: a database for isoform-isoform interactions and isoform network modules

BMC Genomics, 2015
Protein-protein interactions (PPIs) are key to understanding diverse cellular processes and disease mechanisms. However, current PPI databases only provide low-resolution knowledge of PPIs, in the sense that "proteins" of currently known PPIs generally ...
Y. Tseng, Wenyuan Li, Ching-Hsien Chen, Shihua Zhang, Jeremy J. W. Chen, X. Zhou, Chun-Chi Liu   +6 more
semanticscholar   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Time-course RNA-Seq profiling reveals isoform-level gene expression dynamics of the cGAS-STING pathway

Computational and Structural Biotechnology Journal, 2022
The cGAS-STING pathway, orchestrating complicated transcriptome-wide immune responses, is essential for host antiviral defense but can also drive immunopathology in severe COVID-19.
Jing Sun, Lu Li, Jiameng Hu, Yan Gao, Jinyi Song, Xiang Zhang, Haiyang Hu   +6 more
doaj  

CRISPR/Cas9 interrogation of the mouse Pcdhg gene cluster reveals a crucial isoform-specific role for Pcdhgc4.

PLoS Genetics, 2019
The mammalian Pcdhg gene cluster encodes a family of 22 cell adhesion molecules, the gamma-Protocadherins (γ-Pcdhs), critical for neuronal survival and neural circuit formation.
Andrew M Garrett, Peter J Bosch, David M Steffen, Leah C Fuller, Charles G Marcucci, Alexis A Koch, Preeti Bais, Joshua A Weiner, Robert W Burgess   +8 more
doaj   +1 more source

Human central nervous system (CNS) ApoE isoforms are increased by age, differentially altered by amyloidosis, and relative amounts reversed in the CNS compared with plasma [PDF]

, 2016
The risk of Alzheimer's disease (AD) is highly dependent on apolipoprotein-E (apoE) genotype. The reasons for apoE isoform-selective risk are uncertain; however, both the amounts and structure of human apoE isoforms have been hypothesized to lead to ...
Baker-Nigh, Alaina T, Bateman, Randall J, Bollinger, James G, Cairns, Nigel J, Franklin, Erin E, Holtzman, David, Jiang, Hong, Kasten, Tom, Liao, Fan, Mawuenyega, Kwasi G, Morris, John C, Ovod, Vitaliy   +11 more
core   +3 more sources

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source