Results 161 to 170 of about 282,788 (245)

Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance

Advanced Science, EarlyView.
Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao, Xianqun Hu, Ying Wu, Xiang Zhou, Bo Zhang, Song Yang   +5 more
wiley   +1 more source

Author response: Importance of miRNA stability and alternative primary miRNA isoforms in gene regulation during Drosophila development

, 2018
Li Zhou, Mandy Yu Theng Lim, Prameet Kaur, Abil Saj, Diane Bortolamiol-Bécet, Vikneswaran Gopal, Nicholas S. Tolwinski, Greg Tucker‐Kellogg, Katsutomo Okamura   +8 more
openalex   +1 more source

A novel androgen-regulated isoform of the TSC2 tumour suppressor gene increases cell proliferation [PDF]

, 2013
Jennifer Munkley, Prabhakar Rajan, Nicholas P. Lafferty, Caroline Dalgliesh, Robert M. Jackson, Craig Robson, Hing Y. Leung, David J. Elliott   +7 more
openalex   +1 more source

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

Genome annotations matter: characterizing Ensembl hg38 annotations from 2014 to 2023. [PDF]

BMC Genomics
Page ML, Wadsworth ME, Aguzzoli Heberle B, Fardo DW, Ebbert MTW.   +4 more
europepmc   +1 more source

ALDOA‐Mediated Metabolic Reprogramming is a Targetable Vulnerability for Ferroptosis Sensitization in Cancer

Advanced Science, EarlyView.
ALDOA‐depletion‐mediated glycolytic reprogramming promotes autophagy‐mediated degradation of MBOAT2, increasing the ratio of phospholipids containing pro‐ferroptotic polyunsaturated fatty acids over anti‐ferroptotic monounsaturated fatty acids, and thus sensitizing cancer cells to ferroptosis.
Pengqi Wang, Kezhang He, Bowen Wang, Wei Zhou, Ying Zhang, Tianhua Ma, Sheng Ding   +6 more
wiley   +1 more source

Knockdown of HDAC3 promotes the transcription of exon 4-containing isoform in BIM gene. from Histone Deacetylase 3 Inhibition Overcomes <i>BIM</i> Deletion Polymorphism–Mediated Osimertinib Resistance in <i>EGFR-</i>Mutant Lung Cancer

, 2023
Azusa Tanimoto, Shinji Takeuchi, Sachiko Arai, Koji Fukuda, Tadaaki Yamada, Xavier Roca, S. Tiong Ong, Seiji Yano   +7 more
openalex   +1 more source

Tissue-specific isoform usage and gene expression revealed through RNA-seq and ATAC-seq in developing cattle. [PDF]

BMC Genomics
Khilji SF, Xie S, Becker GM, Shira KA, Stegemiller MR, Woods JL, Williams JE, Christensen LE, Konetchy DE, Hagen DE, Murdoch GK, McKay SD, Murdoch BM.   +12 more
europepmc   +1 more source

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

MOESM6 of Systemic response to rupture of intracranial aneurysms involves expression of specific gene isoforms

, 2019
Michał Korostyński, Marcin Piechota, Rafał Morga, Dżesika Hoinkis, Sławomir Gołda, Magdalena Zygmunt, Tomasz Dziedzic, Marek Moskała, Agnieszka Słowik, Joanna Pera   +9 more
openalex   +1 more source