Results 171 to 180 of about 282,788 (245)

Long-Read Sequencing Reveals Cell- and State-Specific Alternative Splicing in 293T and A549 Cell Transcriptomes. [PDF]

Int J Mol Sci
Li X, Que H, Liu Z, Xu G, Wang Y, Cong Z, Leng L, Wu S, Chen C.   +8 more
europepmc   +1 more source

IDP-ASE: haplotyping and quantifying allele-specific expression at the gene and gene isoform level by hybrid sequencing. [PDF]

Nucleic Acids Res, 2017
Deonovic B, Wang Y, Weirather J, Wang XJ, Au KF.   +4 more
europepmc   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Additional file 2 of Integrative expression network analysis of microRNA and gene isoforms in sacred lotus

, 2020
Yue Zhang, Razgar Seyed Rahmani, Xingyu Yang, Jinming Chen, Tao Shi   +4 more
openalex   +1 more source

Beyond Catalytic Therapy: Copper‐Paeonol Nanozymes Disrupt Fascin‐Mediated Actin Bundling to Suppress Tumor Growth and Metastasis

Advanced Science, EarlyView.
Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang, Huajun Li, Yisen Wang, Jie Xiang, Lei Fan, Shengzhe Zhang, Lizeng Gao, Hua Dai, Juqun Xi   +8 more
wiley   +1 more source

Human facilitative glucose transporters. Isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6).

, 1990
T. Kayano, Charles Burant, Hirofumi Fukumoto, Gwyn W. Gould, Yao Fan, Roger L. Eddy, M.G. Byers, T.B. Shows, Susumu Seino, G I Bell   +9 more
openalex   +1 more source

Autoimmune regulator gene, Aire, is involved in central tolerance to the DM20 isoform of proteolipid protein and the prevention of autoimmune inflammation [PDF]

, 2014
Asako Tagawa, Toshimasa Aranami, Mitsuru Matsumoto, Takashi Yamamura   +3 more
openalex   +1 more source

Alternative Splicing (AS) Provides an Alternative Mechanism for Regulating GLIS3 Expression and Activity. [PDF]

Cells
Scoville DW, Grimm SA, Williams JG, Jetten AM.   +3 more
europepmc   +1 more source

The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis

Advanced Science, EarlyView.
Dietary habits play a key role in chronic diseases, and higher annual consumption of fruit and vegetable may lower risk of dementia. Artificial intelligence predicts the lipid‐like compound α‐Amyrin (αA) from plants with edible peels as a drug candidate against Alzheimer's disease.
Shu‐Qin Cao, Juan Ignacio Jiménez‐Loygorri, Yunguang Qiu, You Jung Kang, Khanh Van Do, Annabel E. Smith, Junjie Huang, Jun‐ping Pan, Lipeng Mao, Ang Li, Hangge Yang, Yahyah Aman, Maria Jose Donate Lagartos, Sofie Hindkjær Lautrup, Anbin Chen, Kristina Xiao Liang, Hailong Zhang, Juan Yi, Xurui Jin, Tin Cho Cheung, Olympia Apokotou, Florentia Papastefanaki, Rebecca Matsas, William A. McEwan, Feixiong Cheng, Hansang Cho, Guobing Chen, Huanxing Su, Konstantinos Palikaras, Oscar Junhong Luo, Qian Hua Zhao, Ding Ding, Cornelia van Duijn, Nektarios Tavernarakis, Patricia Boya, Tewin Tencomnao, Evandro F. Fang   +36 more
wiley   +1 more source

Cloning and Expression of Two Soluble Acid Invertase Gene Isoforms from Rhododendron [PDF]

, 2014
Lisi He, Su JiaLe, Xiaoqing Liu, Chang Li, Chen Shangping   +4 more
openalex   +1 more source