Results 231 to 240 of about 282,788 (245)

A single-cell atlas of RNA alternative splicing in the glioma-immune ecosystem. [PDF]

Genome Biol
Song X, Tiek D, Lu M, Yu X, Wu R, Walker M, He Q, Sisbarro D, Hu B, Cheng SY.   +9 more
europepmc   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Single-cell profiling reveals three endothelial-to-hematopoietic transitions with divergent isoform expression landscapes. [PDF]

Nat Cardiovasc Res
Neo WH, Fadlullah MZH, Bhatnagar H, Barone C, Quattrini G, Timóteo-Ferreira F, Carrelha J, Sala G, Sellers R, Weightman J, Breitwieser W, Moncaut N, Thambyrajah R, Jacobsen SEW, Iqbal M, Baker SM, Azzoni E, Lie-A-Ling M, Lacaud G.   +18 more
europepmc   +1 more source

A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

Advanced Science, EarlyView.
The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka   +10 more
wiley   +1 more source

Cross-Species Insights Into Gamma Herpesvirus Transcriptomes: Long-Read and Multi-Omics Perspectives. [PDF]

J Med Virol
Shekhar R, McMahon S, Tibbetts SA, Flemington EK, Renne R.   +4 more
europepmc   +1 more source

Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy

Advanced Science, EarlyView.
A thermo‐responsive cascade nanozyme (Ru‐GOx‐PNN) synergistically enhances mild photothermal therapy by dual suppression of HSP70 through ROS‐induced lipid peroxidation and ATP depletion. This intelligent system effectively overcomes thermotolerance and amplifies apoptosis, offering a safe and precise strategy for tumor treatment.
Shuyu Wang, Shenghui Wang, Mengyuan Cao, Lulu Wang, Wei Jiang, Xiyun Yan, Ying Liu, Bing Jiang   +7 more
wiley   +1 more source

Molecular Responses to Avian Reovirus Inoculation In Vitro. [PDF]

Viruses
Khalid Z, Hauck R.
europepmc   +1 more source

A TIR-NLR gene from Arabidopsis Pla-1 confers resistance to geminivirus infection. [PDF]

Plant J
Shen W, Rajrani R, Reyes MI, Wheeler E, Deppong D, Mickelson-Young L, Ndunguru J, Hanley-Bowdoin L, Ascencio-Ibáñez JT.   +8 more
europepmc   +1 more source

To be or not to be a protein coding mutation, that's the question! [PDF]

NAR Genom Bioinform
De Groote D, Pepe D, Janssens X, De Keersmaecker K.   +3 more
europepmc   +1 more source