Results 241 to 250 of about 7,252,476 (351)

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Genome-Wide Isoform Switching Reveals SR45-Mediated Splicing Control of <i>Arabidopsis</i> Leaf Senescence. [PDF]

Int J Mol Sci
Albaqami M, Almaghrabi GO.
europepmc   +1 more source

Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3)

, 2006
Silvia Canaider, Federica Facchin, Cristiana Griffoni, Raffaella Casadei, Lorenza Vitale, Luca Lenzi, Flavia Frabetti, Pietro D’Addabbo, Paolo Carinci, Maria Zannotti, Pierluigi Strippoli   +10 more
openalex   +2 more sources

Blocking Lysine Crotonylation and Aerobic Glycolysis as Targeting Strategy Against mpox Virus Replication

Advanced Science, EarlyView.
Wei et al. report that MPXV infection induces aerobic glycolysis, a process mediated by the viral protein I3 through lysine crotonylation at its K102 residue. The acetyltransferase MYST1 catalyzes the crotonylation of I3 to inhibit the ubiquitin‐mediated degradation of WDR26.
Pengjun Wei, Zongzheng Zhao, Ruoqi Xu, Qin Yan, Liangzi Jiang, Fuxiao Geng, Yang Gu, Tianjiao Wang, Jing Zhou, Xiao Li, Qin Yan, Chun Lu, Wan Li   +12 more
wiley   +1 more source

Gene Therapy for Fragile X Syndrome, Challenges, and Promises. [PDF]

J Gene Med
Velinov M.
europepmc   +1 more source

Additional file 2 of Integrative expression network analysis of microRNA and gene isoforms in sacred lotus

, 2020
Yue Zhang, Razgar Seyed Rahmani, Xingyu Yang, Jinming Chen, Tao Shi   +4 more
openalex   +1 more source

Bifurcate Regulation of Hematopoietic Homeostasis and Bone Osteogenesis by VHL‐HIF2α‐Controlled Adipocyte Function

Advanced Science, EarlyView.
The VHL‐HIF2α (VHL is Von Hippel‐Lindau) axis in adipocytes differentially regulates hematopoiesis and bone formation through stem cell factor (SCF) and chemerin, respectively. This hypoxia‐responsive pathway in adipocytes establishes a systemic signaling network with HSCs and MSCs to maintain tissue homeostasis, revealing a targetable axis for ...
Qian Li, Jia Li, Anshu Tang, Cong Li, Chao Zhang, Congcong Zhang, Yun‐Cai Liu   +6 more
wiley   +1 more source

Advancing automated cell type annotation with large language models and single-cell isoform sequencing. [PDF]

Comput Struct Biotechnol J
Wijewardena H, Bhatia S, Bhattacharya N, Sengupta D, Wu S, Schmitz U.   +5 more
europepmc   +1 more source

Differential Characteristics and Subcellular Localization of Two Starch-branching Enzyme Isoforms Encoded by a Single Gene inPhaseolus vulgaris L. [PDF]

, 2002
Shigeki Hamada, Hiroyuki Ito, Susumu Hiraga, Keisuke Inagaki, Kouichi Nozaki, Naoto Isono, Yasushi Yoshimoto, Yasuhito Takeda, Hirokazu Matsui   +8 more
openalex   +1 more source

Analysis of Fractalkine Receptor CX3CR1 Function by Targeted Deletion and Green Fluorescent Protein Reporter Gene Insertion

Molecular and Cellular Biology, 2000
Steffen Jung, J. Aliberti, Petra Graemmel, M. Sunshine, G. Kreutzberg, A. Sher, D. Littman   +6 more
semanticscholar   +1 more source