Results 241 to 250 of about 6,900,738 (371)

Characterization of a new isoform of the NFAT (nuclear factor of activated T cells) gene family member NFATc

, 1996
Jungchan Park, Atsuko Takeuchi, Surendra K. Sharma   +2 more
openalex   +1 more source

Mechanical Stress Induced NOX2 Promotes Endothelial Dysfunction in Ventilator‐Induced Lung Injury: Potential Treatment with Quercetin

Advanced Science, EarlyView.
Abnormal mechanical stretch induced by mechanical ventilation (MV) disrupts endothelial junctions via the NOX2/ROS/CaMKII/ERK1/2 axis both in human aortic endothelial cells (HAECs) in vitro and in ventilator‐induced lung injury (VILI) in mice. Quercetin, an antioxidant predicted to bind to NOX2, can effectively prevent mechanical stretch‐induced ...
Tao Jiang, Yabing Zhang, Zhiye Guo, He Ren, Weiyi Hu, Qingping Yao, Yunlong Huo, Yingxin Qi, Kai Huang   +8 more
wiley   +1 more source

Human Ca2+/Calmodulin-dependent Protein Kinase Kinase β Gene Encodes Multiple Isoforms That Display Distinct Kinase Activity [PDF]

, 2001
Li‐Sung Hsu, Gen-Der Chen, Liang-Shong Lee, Chin-Wen Chi, Jan‐Fang Cheng, Jeou-Yuan Chen   +5 more
openalex   +1 more source

TNNT1, TNNT2, and TNNT3: Isoform genes, regulation, and structure-function relationships.

Gene, 2016
Bin Wei, J. Jin
semanticscholar   +1 more source

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

A new human gene (TPRD) and its cDNA isoforms isolated from Down syndrome-critical region of chromosome 21q22.2.

, 1997
Fujiko Tsukahara, Masahira Hattori, Ikuko Urakawa, Yoshivuki Sakaki, Takamura Muraki   +4 more
openalex   +1 more source

In Situ Assembly of Fluorogenic RNA for Screening Natural Anti‐Liver Fibrosis Products via Dynamic Visualization of COL1A1 mRNA

Advanced Science, EarlyView.
This study introduces an in situ assembly of fluorogenic RNA approach for screening natural anti‐liver fibrosis compounds and dynamic visualization of endogenous COL1A1 mRNA in live cells. It offers a simple, cost‐effective approach of visualizing RNA dynamics and conducting drug screening in live cells, presenting a significant potential for the ...
Rui Bai, Li‐Zeng Zhu, Changfa Shao, Zheng Yin, Qun Liu, Yu Gu, Bin Liu   +6 more
wiley   +1 more source

Cartilaginous fish and mammalian connectin evolved independently from an ancestral bony fish-like structure. [PDF]

Sci Rep
Hanashima A, Ujihara Y, Kimoto M, Ohira M, Usui Y, Hashimoto K, Mohri S.   +6 more
europepmc   +1 more source

Transcriptional dysregulation of the p73L / p63 / p51 / p40 / KET gene in human squamous cell carcinomas: expression of Δ Np73L, a novel dominant-negative isoform, and loss of expression of the potential tumour suppressor p51 [PDF]

, 2001
Makoto Senoo, Izumi Tsuchiya, Yukiko Matsumura, Takahiro Mori, Yuki Saito, Hiroyuki Kato, Takashi Okamoto, Sonoko Habu   +7 more
openalex   +1 more source

NPR1 Promotes Lipid Droplet Lipolysis to Enhance Mitochondrial Oxidative Phosphorylation and Fuel Gastric Cancer Metastasis

Advanced Science, EarlyView.
NPR1 induces lipolysis of stored lipid droplet and enhances mitochondrial oxidative phosphorylation to fuel gastric cancer metastasis. Specifically, NPR1‐mediated activation of PKG directly phosphorylates and activates HSL at Ser855 and Ser951, thereby driving lipolytic processes.
Huafeng Fu, Jie Zhang, Hengxing Chen, Haobin Hou, Huanjie Chen, Rongman Xie, Yanlei Chen, Jian Zhang, Dehua Liu, Leping Yan, Rui L. Reis, Joaquim M. Oliveira, Yulong He, Li Zhong, Qinbo Cai, Dongjie Yang   +15 more
wiley   +1 more source