Results 261 to 270 of about 6,900,738 (371)

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress with Ferroptosis

Advanced Science, EarlyView.
Alves et al. reveal how energy loss and oxidative stress, two major features of Alzheimer's disease, are connected. Mitochondria controls the flux of the antioxidant glutathione (GSH), via facilitating both its production and consumption. Energy restriction limits GSH synthesis, conferring vulnerability to cell death by ferroptosis, implicated as a ...
Francesca Alves, Darius Lane, Adam Wahida, Md. Jakaria, Pawel Kalinowski, Adam Southon, Abdel Ali Belaidi, Teresa Samperi‐Esteve, Triet Phu Minh Nguyen, Peng Lei, Marcus Krueger, Stefan Mueller, Marcus Conrad, Puja Agarwal, Sue E Leurgans, Julie Schneider, Ashley I. Bush, Scott Ayton   +17 more
wiley   +1 more source

Isoform characterization of m⁶A in single cells identifies its role in RNA surveillance. [PDF]

Nat Commun
Ren Z, He J, Huang X, Gao Y, Wei C, Wu Z, Guo W, Wang F, Zhao Q, Sun X, Zhang J, Cao N, Lin L, Wang J, Cun Y.   +14 more
europepmc   +1 more source

SF3A3 Drives Tumorigenesis in Endometrial Cancer by Enhancing c‐FOS Expression and Represents a Potential Therapeutic Target

Advanced Science, EarlyView.
The role of splicing factor 3A subunit 3 (SF3A3) in driving endometrial cancer (EC) progression and potential therapeutic interventions. SF3A3, a core component of the U2 small nuclear ribonucleoprotein (U2 snRNP), is upregulated in endometrial cancer (EC) and promotes tumor growth and cisplatin resistance. RNA‐binding protein immunoprecipitation (RIP)
Wei Yu, Yi Gu, Hengrui Zhang, Wunan Huang, Lei Sun, Liangjian Ma, Xiaolei Liang, Lexin Liu, Guiping Chen, Weihua Wang, Zhongkai Cao, Xue Li, Xiangjun Chen, Lidan Hu   +13 more
wiley   +1 more source

Protein and Gene Expression of Nitric Oxide Synthase Isoforms I and III in the Rat Penile Shaft [PDF]

, 2001
Chris M. Gonzalez, Robert E. Brannigan, Troy Bervig, David J. Zelner, Carol A. Podlasek, Kevin E. McKenna, Kevin T. McVary   +6 more
openalex   +1 more source

Convergent Evolution of Two Dopamine Receptor Genes: Repeated Evolution of Exon 6 Skipping in Drd2, and Repeated Deletion of Exon 6 in Drd3. [PDF]

J Mol Evol
Peglar MT, Fryxell KJ.
europepmc   +1 more source

Alternative Splicing of the HumanRab6AGene Generates Two Close but Functionally Different Isoforms

, 2000
Arnaud Échard, Frank J.M. Opdam, Hubert J.P.C. de Leeuw, Florence Jollivet, Paul J.M. Savelkoul, Wiljan Hendriks, Jan Voorberg, Bruno Goud, Jack Fransen   +8 more
openalex   +2 more sources

Gene Duplication Events Producing Muscle (M) and Brain (B) Isoforms of Cytoplasmic Creatine Kinase: cDNA and Deduced Amino Acid Sequences from Two Lower Chordates [PDF]

, 2001
Nicole A. Graber, W. Ross Ellington
openalex   +1 more source

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways

Advanced Science, EarlyView.
EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen, Ying Li, Yan Yu, Mingze Cai, Hao Li, Minghe Huang, Guochao Yang, Jiageng Guo, Huailin Wang, Zhihong Song, Wei Shen, Huihui Jiang, Haitao Wu   +12 more
wiley   +1 more source

isoISG - isoforms of Interferon-Stimulated Genes

Welcome to the isoISG entry This entry serves as a source of annotation data, scripts, and supplementary data for our paper titled "Functional and Dynamic Profiling of Transcript Isoforms Reveals Essential Roles of Alternative Splicing in Interferon Response." In this study, we generated a novel isoform annotation for IFN-α-stimulated and ...
openaire   +2 more sources

Allelic expression patterns of imprinted and non-imprinted genes in cancer cell lines from multiple histologies. [PDF]

Clin Epigenetics
Krushkal J, Jensen TL, Wright G, Zhao Y.
europepmc   +1 more source