Results 271 to 280 of about 7,252,476 (351)

A TIR-NLR gene from Arabidopsis Pla-1 confers resistance to geminivirus infection. [PDF]

Plant J
Shen W, Rajrani R, Reyes MI, Wheeler E, Deppong D, Mickelson-Young L, Ndunguru J, Hanley-Bowdoin L, Ascencio-Ibáñez JT.   +8 more
europepmc   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

To be or not to be a protein coding mutation, that's the question! [PDF]

NAR Genom Bioinform
De Groote D, Pepe D, Janssens X, De Keersmaecker K.   +3 more
europepmc   +1 more source

Knock-Out of Specific DMD Gene Isoforms in the Parental hESC Line SA001 Using CRISPR/Cas9

Laure Chatrousse, Thifaine Poullion, Hamel Miahou, Lina El Kassar, Karine Giraud-Triboult, Claire Boissart, Alexandra Benchoua   +6 more
openalex   +1 more source

Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming

Advanced Science, EarlyView.
Single‐cell profiling of TF‐induced forward programming versus stepwise dual‐SMAD differentiation reveals that divergent trajectories set the pace of neurogenesis. OLIG TFs advance cell‐cycle exit via NOTCH modulation, while NEUROD2 later accelerates maturation. The study elucidates transcriptional mechanisms governing differentiation timing, providing
Lingling Zhu, Weiguang Wang, Jian Zhang, Lei Liu, Minpeng Huang, Lei Diao, Shuang Feng, Qiong Yang, Hao Qiu, Bing Pan, Renee A Reijo Pera, Ji Liu, Ninuo Xia, Fang Fang   +13 more
wiley   +1 more source

Molecular Responses to Avian Reovirus Inoculation In Vitro. [PDF]

Viruses
Khalid Z, Hauck R.
europepmc   +1 more source

Novel mutations in the long isoform of the USH2A gene in patients with Usher syndrome type II or non-syndromic retinitis pigmentosa

Journal of Medical Genetics, 2010
T. L. McGee, B. J. Seyedahmadi, Meredith O. Sweeney, T. Dryja, E. Berson   +4 more
semanticscholar   +1 more source

Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma

Advanced Science, EarlyView.
Lactylation, linked to glycolysis, is poorly understood in regulation. It is found that LDHA is lactylated at Lys81/Lys318 by AARS1, boosting its activity and cellular lactylation via positive feedback in LUAD. Lactylation regulates NHEJ‐related proteins; their delactylation impairs NHEJ and increases cisplatin sensitivity, offering anticancer insights.
Jizhuo Li, Wenze Xun, Xijie Wang, Ruiguang Luo, Qifan Hu, Zhaocai Zhou, Jian Yuan, Yanan Wang, Xiaorui Wan, Tao Zhao, Tianyu Han, Jian‐Bin Wang   +11 more
wiley   +1 more source

The Role of Alternative Splicing in Polyploids in Response to Abiotic Stress. [PDF]

Int J Mol Sci
Fatima F, Yoo MJ.
europepmc   +1 more source

Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: A mechanism for the generation of glucocorticoid resistance

Proceedings of the National Academy of Sciences of the United States of America, 2001
J. C. Webster, R. Oakley, C. Jewell, J. Cidlowski   +3 more
semanticscholar   +1 more source