Results 271 to 280 of about 6,900,738 (371)

KRAS/ABHD17C/ALOX15B Axis Promotes Pancreatic Cancer Progression via Ferroptosis Evasion

Advanced Science, EarlyView.
Phosphorylation of ABHD17C induced by KRASmut/ERK signaling facilitates ALOX15B depalmitoylation and degradation via the CUL4/DDB1/DCAF10 complex, thereby enabling KRASmut‐PDAC cell to evade ferroptosis. Methyl protodioscin inhibits KRASmut‐PDAC progression by disrupting the ABHD17C/ALOX15B interaction and inducing ferroptosis, which represents a ...
Man Li, Xuexin Yu, Yuanji Liu, Shuqin Ouyang, Long Wu, Xiaohong Chen, Huiqi Yu, Haoming Chen, Senmao Lian, Ziwen Li, Liyun Gong, Libing Song, Jun Li   +12 more
wiley   +1 more source

Dynamic Expression of Broad-Complex Isoforms Mediates Temporal Control of an Ecdysteroid Target Gene at the Onset of Drosophila Metamorphosis

, 2000
Bruno Mugat, Véronique Brodu, Jana Kejzlarová‐Lepesant, Christophe Antoniewski, Cynthia A. Bayer, James W. Fristrom, Jean‐Antoine Lepesant   +6 more
openalex   +1 more source

Neither the New Zealand Genetically Hypertensive Strain nor Dahl Salt-Sensitive Strain Has an A1079T Transversion in the α1 Isoform of the Na ⁺ ,K ⁺ -ATPase Gene [PDF]

, 2001
Ross Barnard, Gregory M. Kelly, Sergio Manzetti, Eugenie L. Harris   +3 more
openalex   +1 more source

Intestinal Clock Promotes Cognitive Memory Through Adenosine Signaling

Advanced Science, EarlyView.
The intestinal clock controls the expression of an adenosine enzyme that modulates systemic adenosine level and A1R signaling in the hippocampus, and in turn, cognitive function involving long‐term potentiation and BDNF‐dependent synaptic changes.
Min Chen, Fugui Zhang, Yifei Xiao, Xuejun Jiang, Zhiqian Yan, Jinyi Wang, Xiting Lv, Jialu Cui, Linna Ha, Hui Chen, Yongkang Dang, Zifei Qin, Jing Yang, Baojian Wu   +13 more
wiley   +1 more source

Splice-modulating strategies targeting the insulin receptor: A novel therapeutic pathway in osteosarcoma. [PDF]

Mol Ther Oncol
Singh DR, Singh R, Balusu R, Challagundla KB.   +3 more
europepmc   +1 more source

Tumor-associated Tenascin-C isoforms promote breast cancer cell invasion and growth by MMP-dependent and independent mechanisms [PDF]

, 2009
A Howe, A Joester, A Orimo, A Siri, A von Holst, AJ Garcia, B Carnemolla, B Jian, BS Nielsen, Caroline J Pennington, CD Roskelley, CY Chung, CY Chung, DA Reardon, David S Guttery, Deborah L Holliday, Dylan R Edwards, E Ioachim, F Rigato, GR Phillips, I Aukhil, I Kalembeyi, J Howard Pringle, J Louise Jones, J Symowicz, Jacqueline A Shaw, JE Murphy-Ullrich, JL Jones, JL Jones, JL Jones, K Katenkamp, KE Wilson, KJ Heppner, KW Kinzler, LF Brown, M Adams, M Balduyck, M Cai, M Dueck, M Egeblad, MD Puente Navazo, MD Sternlicht, Michael D Allen, ML Mercado, MP Shekhar, O De Wever, P Huhtala, P Tremble, PL Jones, Rachael A Hancox, RK Nuttall, RM Neve, Rosemary A Walker, S Meiners, S Sarkar, SS Brack, T Jahkola, T Yoshida, TH Westernoff, W Huang   +59 more
core   +3 more sources

Melanocyte-specific Microphthalmia-associated Transcription Factor Isoform Activates Its Own Gene Promoter through Physical Interaction with Lymphoid-enhancing Factor 1 [PDF]

, 2002
Hideo Saitô, Ken‐ichi Yasumoto, Kazuhisa Takeda, Kazuhiro Takahashi, Atsushi Fukuzaki, Seiichi Orikasa, Shigeki Shibahara   +6 more
openalex   +1 more source

Lysosomal Cathepsin S Escape Facilitates Near Infrared Light‐Triggered Pyroptosis Via an Antibody‐Indocyanine Green Conjugate

Advanced Science, EarlyView.
ICAM1 antibody‐bound ICG triggers tumor‐specific, caspase‐1‐independent pyroptosis via CTSS‐mediated GSDMD cleavage, activates antitumor immunity, and synergizes with anti–PD‐1 therapy, offering a non‐apoptotic strategy to overcome resistance in cancer treatment.
Fan Chen, Xue‐Fei Tian, Teng Yang, Yu‐Jie Dai, Da‐Yuan Chen, Hong‐Bo Chen, Takaya Shimura, Xin‐Fang Li, Chu‐Lin Sha, Qing Ji, Jun Cao, Mei‐Yu Fang, Jin‐Biao Shang, Jian‐Min Fang, Ye Lu, Wei‐Hui Zheng, Peng Guo, Wei‐Hong Tan   +17 more
wiley   +1 more source

PUF60-Regulated Isoform Switching of MAZ Modulates Gastric Cancer Cell Migration. [PDF]

Cancer Med
Xing D, Zhao T, Mao C, Han Z, Cai W, Zhang T, Mei D, Xie W, Yu J, Wu Z, Chen Z, Feng S, Shen X, Xue X, Xiang D.   +14 more
europepmc   +1 more source

Differential Regulation of the Sodium Pump α-Subunit Isoform Gene by Ouabain and Digoxin in Tissues of Rats

, 2000
Hao Wang, Yuan Wei-qing, Zhuo-Ren LU
openalex   +2 more sources