Results 271 to 280 of about 470,447 (304)

From “Junk” to Gene: Curriculum vitae of a Primate Receptor Isoform Gene

Journal of Molecular Biology, 2004
Exonization of Alu retroposons awakens public opinion, particularly when causing genetic diseases. However, often neglected, alternative "Alu-exons" also carry the potential to greatly enhance genetic diversity by increasing the transcriptome of primates chiefly via alternative splicing.Here, we report a 5' exon generated from one of the two ...
Silke S, Singer, Daniela N, Männel, Thomas, Hehlgans, Jürgen, Brosius, Jürgen, Schmitz   +4 more
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Parallel gene size and isoform expansion of ancient neuronal genes

Current Biology
How nervous systems evolved is a central question in biology. A diversity of synaptic proteins is thought to play a central role in the formation of specific synapses leading to nervous system complexity. The largest animal genes, often spanning hundreds of thousands of base pairs, are known to be enriched for expression in neurons at synapses and are ...
Matthew J. McCoy, Andrew Z. Fire
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The Rat H3 Receptor: Gene Organization and Multiple Isoforms

Biochemical and Biophysical Research Communications, 2001
Genomic DNA analysis revealed that the coding region of the rat histamine H3 receptor comprises three exons interrupted by two introns of approximately 1 kb each. Several H3 receptor mRNA variants were identified by PCR and cDNA cloning and sequencing.
Morisset, Séverine, Sasse, Astrid, Gbahou, Florence, Héron, Anne, Ligneau, Xavier, Tardivel-Lacombe, Joël, Schwartz, Jean-Charles, Morisset-Lopez, Séverine   +7 more
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Arylsulfatase D Gene in Xp22.3 Encodes Two Protein Isoforms

DNA and Cell Biology, 2000
The human genome contains six arylsulfatase genes (ARSA-ARSF), of which four are clustered in a distal region of the short arm of the X chromosome (Xp22.3). They were probably generated by a series of evolutionary duplication events; their exon-intron boundaries are identical.
P, Urbitsch, M J, Salzer, P, Hirschmann, P H, Vogt   +3 more
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Signalling by PI3K isoforms: insights from gene-targeted mice

Trends in Biochemical Sciences, 2005
Phosphoinositide 3-kinases (PI3Ks) generate lipids that control a wide variety of intracellular signalling pathways. Part of this diversity in PI3K actions stems from the broad range of protein effectors of the PI3K lipids. A further layer of complexity is added by the existence of multiple isoforms of PI3K.
VANHAESEBROECK B, ALI K, BILANCIO, Antonio, GEERING B, FOUKAS LC   +4 more
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Gene Transfer of Troponin I Isoforms, Mutants, and Chimeras

2003
Thin filament proteins play an essential role in the regulation of myocardial pressure development. Within the thin filament of the sarcomere, troponin I (TnI) plays a key role in regulating the Ca(2+) sensitivity of force. During myocardial development, there is a transition in TnI isoform expression from the slow skeletal isoform (ssTnI) in embryonic/
Margaret V, Westfall, Joseph M, Metzger
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Adenovirus-mediated gene transfer of SERCA isoforms

2000
Cultured chicken embryonic or neonatal rat cardiac myocytes were infected with recombinant adenovirus vectors carrying slow muscle SERCA2a or fast muscle SERCAla cDNA, under control of muscle-specific or constitutive viral promoters. Under optimal conditions, exogenous SERCA expression was obtained in all myocytes in culture, yielding approximately a ...
G. Inesi, M. Cavagna, J. M. O’donnell, C. Sumbilla, L. Zhong, H. Ma, M. G. Klein   +6 more
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Gene duplication and hemoglobin isoform differentiation

2018
Chapter 6 explores the physiological significance of gene duplication and hemoglobin isoform differentiation. Repeated rounds of gene duplication and divergence during the evolution of jawed vertebrates promoted the diversification of the subfamilies of genes that encode the different subunit chains of tetrameric hemoglobin, leading to functional ...
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Heavy Metal Responses of Human Metallothionein Isoform Genes

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Nobuhiko Miura, Shinji Koizumi
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Multiple New Isoforms of the Human Prolactin Receptor Gene

2004
Prolactin (PRL) is a polypeptide hormone with a clear role in promoting mammary gland growth, differentiation, and lactogenesis. In addition, endocrine and/or autocrine/ paracrine PRL (Clevenger et al. 1995; Ginsburg & Vonderhaar 1995) promotes mammary carcinogenesis in rodents (Wennbo et al.
Josephine F, Trott, Russell C, Hovey, Sailaja, Koduri, Barbara K, Vonderhaar   +3 more
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