Results 281 to 290 of about 7,252,476 (351)

TNEA Regulates Hippocampal Oscillation by Improving Inhibitory Synaptic Plasticity to Ameliorates Cognitive Impairment in Alzheimer's Disease

Advanced Science, EarlyView.
TNEA improves cognition in 5xFAD mice by modulating parvalbumin‐positive interneurons in hippocampal CA1. TNEA enhances gamma oscillations during rest and theta power during novel object recognition, restoring excitation/inhibition balance. These findings support TNEA as a minimally invasive therapy for Alzheimer's disease.
Zhongzhao Guo, Hong Ni, Yu Lu, Zhengyu Cui, Yixing Wang, Zilu Zhu, Xinyu Wei, Chenyi Xia, Ming Xu, Lixia Du, Yufang Yang, Shi Shu, Ke Wang, Zhifei Wang, Chunlei Shan, Deheng Wang   +15 more
wiley   +1 more source

Long-read sequencing disentangles isoform complexity at allele-specific loci. [PDF]

Sci Rep
Lemoine L, Hoelzl S, Hasenbein TP, Graf E, Andergassen D.   +4 more
europepmc   +1 more source

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

Journal of Clinical Investigation, 1997
D. Koya, M. Jirousek, Y. Lin, H. Ishii, K. Kuboki, G. King   +5 more
semanticscholar   +1 more source

Single‐Position Peptide Clustering for Peptidomics Reveals Novel Disease Biomarkers and Dysregulated Proteolytic Characteristics

Advanced Science, EarlyView.
A novel amino acid (aa)‐score‐based single‐position peptide clustering strategy is developed for peptidomics, enabling precise profiling of protein proteolysis in plasma from β‐thalassemia cohort. The method identifies new aa position‐based peptide cluster biomarkers validated by heavy‐labeled peptides, visualizes aggregated changes, uncovers disease ...
Na Li, Yaxin Zhu, Yumeng Yan, Jifeng Wang, Lili Niu, Xiang Ding, Mengmeng Zhang, Zhensheng Xie, Tanxi Cai, Xiaojing Guo, Jianming Luo, Peng An, Xiangqian Guo, Fuquan Yang   +13 more
wiley   +1 more source

Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brain. [PDF]

Genome Biol
De Paoli-Iseppi R, Joshi SS, Gleeson J, Prawer YDJ, You Y, Agarwal R, Li A, Hull A, Whitehead EM, Seo Y, Kujawa R, Chang R, Dutt M, McLean C, Parker BL, Clark MB.   +15 more
europepmc   +1 more source

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Nuclear CaMKII Isoforms as Regulators of Transcription: From Developmental to Pathological Persistence. [PDF]

Med Sci (Basel)
Gaytán-Gómez AM, Ramos-Cortés CA, Suarez-García RX, Martínez-Islas DA, Marroquin-Aguilar AT, Avelino-Vivas F, Solis-Galván DM, Laguna-González AA, García-García BM, Minaya-Pérez E, Quiñones-Lara E, Muciño-Galicia AE, Villamar-Cruz O, Arias-Romero LE, León-Cabrera S, Armas-López L, Saldívar-Cerón HI.   +16 more
europepmc   +1 more source

Novel Antifungal Scaffold Targeting Tubulin Overcomes Sclerotinia Sclerotiorum Resistance

Advanced Science, EarlyView.
Addressing pesticide resistance, novel chromone‐acylhydrazone hybrids targeting fungal tubulin are synthesized. Compound G24 potently inhibited S. sclerotiorum (EC50 = 0.21µg mL−1) and demonstrated enhanced field performance via microencapsulation, offering a sustainable strategy against resistance and for global food security.
Lihui Shao, Xianqun Hu, Ying Wu, Xiang Zhou, Bo Zhang, Song Yang   +5 more
wiley   +1 more source

In-vitro human myogenesis model reveals novel mRNA alternative splicing isoforms. [PDF]

Sci Rep
Donega S, Banskota N, Yang JH, Rossi M, Piao Y, Tsitsipatis D, Fan J, De S, Peterson CA, McDermott MM, Gorospe M, Ferrucci L.   +11 more
europepmc   +1 more source

Structure of the rat plasma membrane Ca(2+)-ATPase isoform 3 gene and characterization of alternative splicing and transcription products. Skeletal muscle-specific splicing results in a plasma membrane Ca(2+)-ATPase with a novel calmodulin-binding domain.

, 1992
Scott Burk, Gary E. Shull
openalex   +1 more source