Results 71 to 80 of about 139,185 (274)

Non-coding RNAs participate in the regulatory network of CLDN4 via ceRNA mediated miRNA evasion [PDF]

, 2017
Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into “networks” based on their interactions.
Chen, Xiao-wan, Gao, Peng, Miao, Zhi-feng, Shi, Jin-xin, Song, Yong-xi, Sun, Jing-xu, Wang, Zhen-ning, Wu, Zhong-hua, Yang, Yu-chong, Zhao, Jun-hua   +9 more
core   +2 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

NSUN2 affects diabetic retinopathy progression by regulating MUC1 expression through RNA m5C methylation

Journal of Translational Medicine
Background Diabetic retinopathy (DR) is the leading cause of blinding eye disease among working adults and is primarily attributed to the excessive proliferation of microvessels, which leads to vitreous hemorrhage and retinal traction, thereby ...
Runze Wang, Wei Xue, Feifei Kan, Huiying Zhang, Di Wang, Lei Wang, Jianwen Wang   +6 more
doaj   +1 more source

Characterization of Hspb8 in Zebrafish

Cells, 2020
Hspb8 is a member of the small heat shock protein (sHSP) family. Its expression is known to be upregulated under heat shock. This protein interacts with different partners and can, therefore, be involved in various processes relevant to tissue integrity ...
Magda Dubińska-Magiera, Joanna Niedbalska-Tarnowska, Marta Migocka-Patrzałek, Ewelina Posyniak, Małgorzata Daczewska   +4 more
doaj   +1 more source

MOESM1 of Establishment of an innovative and sustainable PCR technique for 1534 locus mutation of the knockdown resistance (kdr) gene in the dengue vector Aedes albopictus

, 2019
Additional file 1: Alignment S1. ClustalW alignment for eight genotypes in the 1534 locus of the kdr gene in Ae. albopictus. The underlined uppercase letters referring to the codons in the 1534 locus, and the letter highlighted in yellow corresponds to the insertion.
Zhu, Cai-Ying, Zhao, Chun-Chun, Wang, Yi-Guan, Ma, De-Ling, Song, Xiu-Ping, Wang, Jun, Meng, Feng-Xia   +6 more
openaire   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons [PDF]

, 2017
Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential ...
Abramov, Andrey Y. Abramov, Angelova, Bartolome, Bobba, Brand, Brown, Charles Arber, Ding, Edri, Elisavet Preza, Eva Carro, Fernando Bartolome, Ganote, Henry Houlden, Imamura, Johnson, Kokoszka, Krauss, Ludtmann, Macarena de Vicente, Marthe H.R. Ludtmann, Meyer, Muqit, Nalbandian, Nalbandian, Nalbandian, Okita, Papkovskaia, Plun-Favreau, Schirris, Selina Wray, Shi, Shi, Sonia Gandhi, Sposito, Vallier, Vieira, Weihl, Weinbach, Weydt, Wray, Yin, Zhivotovsky   +43 more
core   +2 more sources

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Frataxin is essential for zebrafish embryogenesis and pronephros formation

Frontiers in Cell and Developmental Biology
Background and objectivesFriedreich’s Ataxia (FRDA) is a genetic disease that affects a variety of different tissues. The disease is caused by a mutation in the frataxin gene (FXN) which is important for the synthesis of iron-sulfur clusters. The primary
Wesley S. Ercanbrack, Austin Dungan, Ella Gaul, Mateo Ramirez, Alexander J. DelVecchio, Calvin Grass, Rebecca A. Wingert   +6 more
doaj   +1 more source

Gene expression profiling of U2AF2 dependent RNA-protein interactions during CD4+ T cell activation

Genomics Data, 2017
CD4 T cell activation is a central component of the mammalian adaptive immune response and is underscored by a dramatic change in the gene expression profile in these cells. The changes in gene expression that occur during T cell activation are regulated
Thomas C Whisenant
doaj   +1 more source