Results 11 to 20 of about 806,287 (306)
CRISPR/Cas9 high-throughput screening in cancer research [PDF]
E3S Web of Conferences, 2020 In recent years, CRISPR/Cas9 technology has developed rapidly. With its accurate, fast, and simple editing functions that can achieve gene activation, interference, knockout, and knock-in, it has become a powerful genetic screening tool that is widely ...
Liu Zhuoxin
doaj +1 more source
The COVID-19 Gene and Drug Set Library [PDF]
SSRN Electronic Journal, 2020 Abstract The coronavirus (CoV) severe acute respiratory syndrome (SARS)-CoV-2 (COVID-19) pandemic has received rapid response by the research community to offer suggestions for repurposing of approved drugs as well as to improve our understanding of the COVID-19 viral life cycle molecular mechanisms.
Maxim V. Kuleshov +9 more
openaire +3 more sources
Adventures in the enormous: a 1.8 million clone BAC library for the 21.7 Gb genome of loblolly pine. [PDF]
PLoS ONE, 2011 Loblolly pine (LP; Pinus taeda L.) is the most economically important tree in the U.S. and a cornerstone species in southeastern forests. However, genomics research on LP and other conifers has lagged behind studies on flowering plants due, in part, to ...
Zenaida V Magbanua +8 more
doaj +1 more source
Preparation of trinucleotide phosphoramidites as synthons for the synthesis of gene libraries
Beilstein Journal of Organic Chemistry, 2018 The preparation of protein libraries is a key issue in protein engineering and biotechnology. Such libraries can be prepared by a variety of methods, starting from the respective gene library.
Ruth Suchsland +2 more
doaj +1 more source
Analysis of shuffled gene libraries
Journal of Molecular Biology, 2002 In vitro recombination of homologous genes (family shuffling) has been proposed as an effective search strategy for laboratory evolution of genes and proteins. Few data are available, however, on the composition of shuffled gene libraries, from which one could assess the efficiency of recombination and optimize protocols.
Joern, John M +2 more
openaire +3 more sources
Gene expression profiling en association with prion-related lesions in the medulla oblongata of symptomatic natural scrapie animals. [PDF]
, 2011 The pathogenesis of natural scrapie and other prion diseases remains unclear. Examining transcriptome variations in infected versus control animals may highlight new genes potentially involved in some of the molecular mechanisms of prion-induced ...
Bossers, A. +34 more
core +1 more source
Synthetic and Systems Biotechnology, 2017 Engineering cell factories for producing biofuels and pharmaceuticals has spurred great interests to develop rapid and efficient synthetic biology tools customized for modular pathway engineering.
Erqing Jin +5 more
doaj +1 more source
The once and future publishing library [PDF]
, 2015 This report looks at topic of libraries as publishers, with investigations mainly in the U.S. research institution context. Specifically, we reviewed existing literature and conducted a survey of members of the Library Publishing Coalition, seeking to ...
Holzman, Alex +3 more
core +1 more source
Mutant non-coding RNA resource in mouse embryonic stem cells
Disease Models & Mechanisms, 2021 Gene trapping is a high-throughput approach that has been used to introduce insertional mutations into the genome of mouse embryonic stem (ES) cells. It is performed with generic gene trap vectors that simultaneously mutate and report the expression of ...
Jens Hansen +2 more
doaj +1 more source
On the contribution of gene libraries to artificial immune systems [PDF]
Proceedings of the 7th annual conference on Genetic and evolutionary computation, 2005 Gene libraries have been added to Artificial Immune Systems in analogy to biological immune systems, but to date no careful study of their effect has been made. This work investigates the contribution of gene libraries to Artificial Immune Systems by reproducing and extending an earlier system that used gene libraries.
Spellward, P, Kovacs, T
openaire +1 more source