Results 241 to 250 of about 806,287 (306)

Double-CRISPR Knockout Simulation (DKOsim): A Monte-Carlo randomization system to model cell growth behavior and infer the optimal library design for growth-based double knockout screens. [PDF]

PLoS Comput Biol
Gu Y, Hart T, Leon-Novelo L, Shen JP.
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

PRMT1‐Mediated LDHA Methylation Drives STAT3 Lactylation to Orchestrate Intestinal Inflammation and Tumorigenesis

Advanced Science, EarlyView.
This study identifies an immunometabolic axis wherein SAM‐driven PRMT1 methylates LDHA, enhancing its activity. The resultant lactate induces STAT3 K709 lactylation, which stabilizes an active conformation to promote STAT3 phosphorylation and IL‐10 expression.
Hui Wang, Mengyu Zhang, Weipeng Gong, Jiaxuan Wu, Junping Zhang, Wenxiu Zhang, Yue Liu, Kui Wang, Canhua Huang, Jun Zhou, Sijin Wu, Yan Li, Tianliang Li   +12 more
wiley   +1 more source

In Vitro Massively Parallel Screening of Human Regulatory Elements Involved in Postcranial Skeletal Development for Differential Activity Compared to Chimpanzee. [PDF]

Genome Biol Evol
Okamoto AS, Coveney CR, Ganapathee DS, Capellini TD.   +3 more
europepmc   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source

A comprehensive survey of computer vision methods for spatial transcriptomics. [PDF]

Brief Bioinform
Zhu J, Deng R, Guo J, Yao T, Lu S, Qu C, Xiong J, Zhu Y, Lu Z, Yang Y, Lionts M, Tang Y, Xu D, Wang Y, Zhao S, Yang H, Huo Y.   +16 more
europepmc   +1 more source

De novo promoters emerge more readily from random DNA than from genomic DNA. [PDF]

Sci Adv
Fuqua T, Wagner A.
europepmc   +1 more source

CauloKO: an ordered transposon mutant library in <i>Caulobacter crescentus</i>. [PDF]

J Bacteriol
Moore GM, Ramos JG, Sheehan JP, Bratton BP, Gitai Z.   +4 more
europepmc   +1 more source

Hybrid capture RNA-seq defines temporal gene expression in <i>Rickettsia</i>. [PDF]

mSphere
Scott AT, McGinn J, Butty VL, Levine SS, Lamason RL.   +4 more
europepmc   +1 more source

Functional Genomics Screening in <i>Chlamydomonas reinhardtii</i> Maps the Genetic Landscape of Tolerance to Paraquat and Diuron. [PDF]

Environ Sci Technol
Godec T, Bleker C, Stare K, Lukan T, Levak V, Tušek Žnidarič M, Betz A, Kosjek T, van Midden KP, Klemenčič M, Trenti F, Guella G, Sepčić K, Fauser F, Patena W, Jonikas MC, Kerenčič M, Eleršek T, Pietri M, Rodet T, Bren U, Jukić M, Lešnik S, Županič A.   +23 more
europepmc   +1 more source