Results 11 to 20 of about 2,855,271 (302)

Gone with the Species: From Gene Loss to Gene Extinction

Frontiers in Bioscience-Scholar
Background: Vertebrae protein-coding genes exhibit remarkable diversity and are organized into many gene families. These gene families have emerged through various gene duplication events, the most prominent being the two rounds of ...
Ammad Aslam Khan, Anees Fatima
doaj   +3 more sources

Gene therapy for hearing loss [PDF]

Human Molecular Genetics, 2019
Abstract Sensorineural hearing loss (SNHL) is the most common sensory disorder. Its underlying etiologies include a broad spectrum of genetic and environmental factors that can lead to hearing loss that is congenital or late onset, stable or progressive, drug related, noise induced, age related, traumatic or post-infectious. Habilitation
Ryotaro Omichi, Seiji B Shibata, Cynthia C Morton, Richard J H Smith   +3 more
openaire   +2 more sources

Gene Loss Predictably Drives Evolutionary Adaptation [PDF]

Molecular Biology and Evolution, 2020
Abstract Loss of gene function is common throughout evolution, even though it often leads to reduced fitness. In this study, we systematically evaluated how an organism adapts after deleting genes that are important for growth under oxidative stress.
Helsen, Jana, Voordeckers, Karin, Vanderwaeren, Laura, Santermans, Toon, Tsontaki, Maria, Verstrepen, Kevin J., Jelier, Rob   +6 more
openaire   +3 more sources

Gene Loss DB: a curated database for gene loss in mammals-the cetacean collection. [PDF]

Database (Oxford)
Abstract Molecular databases are essential resources for both experimental and computational biologists. The rapid increase in high-quality genome assemblies has led to a surge in publications describing secondary gene loss events associated with lineage-specific adaptations across diverse vertebrate groups.
Themudo GE, Ruivo R, Valente R, Artilheiro N, Oliveira D, Amorim I, Pinto B, Castro LFC, Fernandes S, Lopes-Marques M.   +9 more
europepmc   +3 more sources

Genetic Hearing Loss and Gene Therapy [PDF]

Genomics & Informatics, 2018
Genetic hearing loss crosses almost all the categories of hearing loss which includes the following: conductive, sensory, and neural; syndromic and nonsyndromic; congenital, progressive, and adult onset; high-frequency, low-frequency, or mixed frequency; mild or profound; and recessive, dominant, or sex-linked.
Nathanial T Carpena, Min Young Lee
openaire   +3 more sources

The economics of organellar gene loss and endosymbiotic gene transfer. [PDF]

Genome Biol, 2021
AbstractThe endosymbiosis of the bacterial progenitors of mitochondrion and the chloroplast are landmark events in the evolution of life on earth. While both organelles have retained substantial proteomic and biochemical complexity, this complexity is not reflected in the content of their genomes. Instead, the organellar genomes encode fewer than 5% of
Kelly S.
europepmc   +6 more sources

Evolution by gene loss

Nature Reviews Genetics, 2016
The recent increase in genomic data is revealing an unexpected perspective of gene loss as a pervasive source of genetic variation that can cause adaptive phenotypic diversity. This novel perspective of gene loss is raising new fundamental questions. How relevant has gene loss been in the divergence of phyla? How do genes change from being essential to
Albalat Rodríguez, Ricard, Cañestro García, Cristian   +1 more
openaire   +3 more sources

The Complete Plastome Sequences of Seven Species in Gentiana sect. Kudoa (Gentianaceae): Insights Into Plastid Gene Loss and Molecular Evolution

Frontiers in Plant Science, 2018
The chloroplast (cp) genome is useful in the study of phylogenomics, molecular dating, and molecular evolution. Gentiana sect. Kudoa is a predominantly alpine flowering plant that is valued for its contributions to medicine, ecology, and horticulture ...
Shan-Shan Sun, Peng-Cheng Fu, Xiao-Jun Zhou, Yan-Wei Cheng, Fa-Qi Zhang, Fa-Qi Zhang, Shi-Long Chen, Qing-Bo Gao, Qing-Bo Gao   +8 more
doaj   +1 more source

Evolution of substrate specificity in a retained enzyme driven by gene loss. [PDF]

, 2017
The connection between gene loss and the functional adaptation of retained proteins is still poorly understood. We apply phylogenomics and metabolic modeling to detect bacterial species that are evolving by gene loss, with the finding that ...
Babnigg, Gyorgy, Barona-Gómez, Francisco, Carrillo-Tripp, Mauricio, Edirisinghe, Janaka N, Endres, Michael, Henry, Christopher S, Joachimiak, Andrzej, Juárez-Vázquez, Ana Lilia, Medina-Ruíz, Sofía, Michalska, Karolina, Noda-García, Lianet, Santoyo-Flores, Julián, Ton-That, Hung, Verduzco-Castro, Ernesto A, Wu, Chenggang   +14 more
core   +1 more source

GENE LOSS IN HUMAN TERATOMAS [PDF]

Proceedings of the National Academy of Sciences, 1969
If benign cystic teratomas (dermoid cysts) of the ovary arise from a germ cell that has undergone meiosis, they should be missing genes which are present in the person. Three independently segregating allelic isozymes in 11 benign cystic teratomas of the human female ovary were compared with normal tissue of the same case.
openaire   +2 more sources