Results 191 to 200 of about 2,855,271 (302)

Gene loss and co-option of toll-like receptors facilitate paternal immunological adaptation in the brood pouch of pregnant male seahorses. [PDF]

Front Immunol, 2023
Zhang B, Xiao W, Qin G, Chen Z, Qiu L, Wang X, Lin Q.   +6 more
europepmc   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Gene loss in Antarctic icefish: evolutionary adaptations mimicking Fanconi Anemia? [PDF]

BMC Genomics
Shin SC, Kim S, Kim HW, Lee JH, Kim JH.
europepmc   +1 more source

Phylogenetic distribution of malonate semialdehyde decarboxylase (MSAD) genes among strains within the genus Mycobacterium: evidence of MSAD gene loss in the evolution of pathogenic mycobacteria. [PDF]

Front Microbiol, 2023
Lee D, Kim DH, Seo H, Choi S, Kim BJ.
europepmc   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Comparative plastomes of five <i>Psittacanthus</i> species: genome organization, structural features, and patterns of pseudogenization and gene loss. [PDF]

AoB Plants
Morales-Saldaña S, Barraza-Ochoa AI, Villafán E, Vásquez-Aguilar AA, Ramírez-Barahona S, Ibarra-Laclette E, Ornelas JF.   +6 more
europepmc   +1 more source

Gene loss and symbiont switching during adaptation to the deep sea in a globally distributed symbiosis. [PDF]

ISME J, 2023
Osvatic JT, Yuen B, Kunert M, Wilkins L, Hausmann B, Girguis P, Lundin K, Taylor J, Jospin G, Petersen JM.   +9 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Pervasive Mitochondrial tRNA Gene Loss in Clade B of Haplosclerid Sponges (Porifera, Demospongiae). [PDF]

Genome Biol Evol
Lavrov DV, Turner TL, Vicente J.
europepmc   +1 more source

Gene duplication, gene loss, and recombination events with variola virus shaped the complex evolutionary path of historical American horsepox-based smallpox vaccines. [PDF]

mBio, 2023
Souza ARV, Brinkmann A, Esparza J, Nitsche A, Damaso CR.   +4 more
europepmc   +1 more source