Results 221 to 230 of about 2,855,271 (302)

Corrigendum: Plastome Evolution and Phylogeny of Orchidaceae, With 24 New Sequences

Frontiers in Plant Science, 2020
Young-Kee Kim, Sangjin Jo, Se-Hwan Cheon, Min-Jung Joo, Ja-Ram Hong, Myounghai Kwak, Ki-Joong Kim   +6 more
doaj   +1 more source

Adaptive gene loss in the common bean pan-genome during range expansion and domestication. [PDF]

Nat Commun
Cortinovis G, Vincenzi L, Anderson R, Marturano G, Marsh JI, Bayer PE, Rocchetti L, Frascarelli G, Lanzavecchia G, Pieri A, Benazzo A, Bellucci E, Di Vittori V, Nanni L, Ferreira Fernández JJ, Rossato M, Aguilar OM, Morrell PL, Rodriguez M, Gioia T, Neumann K, Alvarez Diaz JC, Gratias A, Klopp C, Bitocchi E, Geffroy V, Delledonne M, Edwards D, Papa R.   +28 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Author Correction: Adaptive gene loss in the common bean pan-genome during range expansion and domestication. [PDF]

Nat Commun
Cortinovis G, Vincenzi L, Anderson R, Marturano G, Marsh JI, Bayer PE, Rocchetti L, Frascarelli G, Lanzavecchia G, Pieri A, Benazzo A, Bellucci E, Di Vittori V, Nanni L, Ferreira Fernández JJ, Rossato M, Aguilar OM, Morrell PL, Rodriguez M, Gioia T, Neumann K, Alvarez Diaz JC, Gratias A, Klopp C, Bitocchi E, Geffroy V, Delledonne M, Edwards D, Papa R.   +28 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Gene loss and relaxed selection of <i>plaat1</i> in vertebrates adapted to low-light environments. [PDF]

Proc Biol Sci
Drabeck DH, Wiese J, Gilbertson E, Arroyave J, Stiassny MLJ, Alter SE, Borowsky R, Hendrickson DA, Arcila D, McGaugh SE.   +9 more
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Extensive remodeling of sugar metabolism through gene loss and horizontal gene transfer in a eukaryotic lineage. [PDF]

BMC Biol
Pontes A, Paraíso F, Silva M, Lagoas C, Aires A, Brito PH, Rosa CA, Lachance MA, Sampaio JP, Gonçalves C, Gonçalves P.   +10 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source