Results 261 to 270 of about 2,855,271 (302)
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Development Genes and Evolution, 2011
Wnt genes encode secreted glycoproteins that act in cell-cell signalling to regulate a wide array of developmental processes, ranging from cellular differentiation to axial patterning. Discovery that canonical Wnt/β-catenin signalling is responsible for regulating head/tail specification in planarian regeneration has recently highlighted their ...
Nick, Riddiford, Peter D, Olson
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Wnt genes encode secreted glycoproteins that act in cell-cell signalling to regulate a wide array of developmental processes, ranging from cellular differentiation to axial patterning. Discovery that canonical Wnt/β-catenin signalling is responsible for regulating head/tail specification in planarian regeneration has recently highlighted their ...
Nick, Riddiford, Peter D, Olson
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Gene Therapy for Sensorineural Hearing Loss
Ear & Hearing, 2015Gene therapy is a promising treatment modality that is being explored for several inherited disorders. Multiple human gene therapy clinical trials are currently ongoing, but few are directed at hearing loss. Hearing loss is one of the most prevalent sensory disabilities in the world, and genetics play an important role in the pathophysiology of hearing
Wade W, Chien +3 more
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Modifier genes of hereditary hearing loss
Current Opinion in Neurobiology, 2000Phenotypic variation between individuals with the same disease alleles may be attributable to the genotype at another locus, which is referred to as a modifier gene. Recent functional studies of modifier genes of hearing-loss loci have begun to refine our understanding of hearing processes and will guide the rational design of medical therapies for ...
T, Friedman +6 more
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Genes and syndromic hearing loss
Journal of Communication Disorders, 2002Syndromes that are associated with hearing loss include Waardenburg, Stickler (STL), Jervell and Lange-Nielsen, Usher (USH), Alport, mitochondrial encephalomyopathy, lactic acidosis, stroke-like episodes, and sensorineural hearing loss (MELAS) and mitochondrial encephalomyopathy, myoclonus epilepsy, ragged-red fibers, and sensorineural hearing loss ...
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Gene therapy for hereditary hearing loss
Hearing ResearchGene therapy is a technique by which exogenous genetic material is introduced into target cells to treat or prevent diseases caused by genetic mutations. Hearing loss is the most common sensory disorder. Genetic factors contribute to approximately 50 % of all cases of profound hearing loss, and more than 150 independent genes have been reported as ...
Zeming Fu +3 more
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Drug-Induced Loss of Unstably Amplified Genes
Cancer Investigation, 1990Methotrexate-resistant R500 cells slowly lose amplified dihydrofolate reductase (dhrf) genes with biphasic kinetics when grown in the absence of methotrexate. Both phases of gene loss were markedly accelerated by subcytotoxic drug treatments. R500 cells were passed in low concentrations of cytotoxic drugs (inhibitors of ribonucleotide reductase, type I
M A, Wani, R M, Snapka
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Loss of duplicate gene expression after polyploidisation
Nature, 1977INCREASES in cellular DNA content have been important in the evolution of eukaryotes1–3. One mechanism for increasing DNA content is polyploidisation, which has been observed in a wide variety of organisms4–8, and which is believed to have preceded the evolution of the early vertebrates9.
S D, Ferris, G S, Whitt
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Reconstructing Gene Gains and Losses with BadiRate
2022Estimating gene gain and losses is paramount to understand the molecular mechanisms underlying adaptive evolution. Despite the advent of high-throughput sequencing, such analyses have been so far hampered by the poor contiguity of genome assemblies.
Pablo, Librado, Julio, Rozas
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Gene Therapy for Hearing Loss: Which Genes Next?
Otology & NeurotologyIntroduction Hearing loss is the most common sensory deficit in humans, and roughly half of childhood-onset sensorineural hearing loss is genetic. Advances in gene therapy techniques have led to the first clinical trials for OTOF-associated hearing loss DFNB9.
Ryan J. Carlson +2 more
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