Results 71 to 80 of about 6,611,862 (305)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Selection-Driven Gene Loss in Bacteria
PLoS Genetics, 2012 Gene loss by deletion is a common evolutionary process in bacteria, as exemplified by bacteria with small genomes that have evolved from bacteria with larger genomes by reductive processes. The driving force(s) for genome reduction remains unclear, and here we examined the hypothesis that gene loss is selected because carriage of superfluous genes ...
Koskiniemi S +3 more
openaire +5 more sources
Genomic Variability of Monkeypox Virus among Humans, Democratic Republic of the Congo
Emerging Infectious Diseases, 2014 Monkeypox virus is a zoonotic virus endemic to Central Africa. Although active disease surveillance has assessed monkeypox disease prevalence and geographic range, information about virus diversity is lacking.
Jeffrey R. Kugelman +18 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Identification and characterisation of gene regulation by the POU4F3 (BRN-3C) transcription factor in the inner ear [PDF]
, 2010 Hair cells are the mechanosensory cells of the inner ear whose loss causes irreversible hearing loss in mammals. POU4F3, a POU-domain transcription factor, is only expressed in hair cells in the inner ear and is essential for hair cell terminal ...
Tornari, C.
core
Gene Family Evolution by Duplication, Speciation, and Loss [PDF]
Journal of Computational Biology, 2008 We consider two algorithmic questions related to the evolution of gene families. First, given a gene tree for a gene family, can the evolutionary history of this family be explained with only speciation and duplication events? Such gene trees are called DS-trees.
Cédric Chauve +2 more
openaire +3 more sources
Potential allopolyploid origin of Ericales revealed with gene-tree reconciliation
Frontiers in Plant Science, 2022 Few incidents of ancient allopolyploidization (polyploidization by hybridization or merging diverged genomes) were previously revealed, although there is significant evidence for the accumulation of whole genome duplications (WGD) in plants.
Shuai Nie +13 more
doaj +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Studying Corruption and Anticorruption in a Late Medieval Commune: The case of Thirteenth- and Fourteenth-century Bologna [PDF]
, 2023 This paper explores the historical meaning of corruption and its forms of contrast in late medieval Bologna. It focuses on understanding the different and changing notions this form of classifiable crime, performed by public officers, assumed in the ...
Edward Loss
core +1 more source
Loss of retinoblastoma gene and amplification of N-myc gene in retinoblastoma [PDF]
Journal of Korean Medical Science, 1993 We have analyzed paired samples of genomic DNA from peripheral leukocyte and primary tumor tissue from nine patients with retinoblastoma (RB) and from two RB cell lines, WERI-Rb-1 and Y79, to detect the molecular alterations of the retinoblastoma susceptibility gene (RB-1) and N-myc gene.
S W, Choi +5 more
openaire +2 more sources