Results 51 to 60 of about 5,894,586 (297)

Modelling nonstationary gene regulatory processes [PDF]

, 2010
An important objective in systems biology is to infer gene regulatory networks from postgenomic data, and dynamic Bayesian networks have been widely applied as a popular tool to this end.
Husmeier, D., Rahnenführer, J., Dirk Husmeier, Marco Grzegorcyzk, Grzegorcyzk, M., Jörg Rahnenführer   +5 more
core   +1 more source

Gene-centered regulatory networks [PDF]

Briefings in Functional Genomics, 2009
Differential gene expression plays a critical role in the development and physiology of multicellular organisms. At a 'systems level' (e.g. at the level of a tissue, organ or whole organism), this process can be studied using gene regulatory network (GRN) models that capture physical and regulatory interactions between genes and their regulators.
Arda, H. Efsun, Walhout, Albertha J M
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Conserved Disease Modules Extracted From Multilayer Heterogeneous Disease and Gene Networks for Understanding Disease Mechanisms and Predicting Disease Treatments

Frontiers in Genetics, 2019
Disease relationship studies for understanding the pathogenesis of complex diseases, diagnosis, prognosis, and drug development are important. Traditional approaches consider one type of disease data or aggregating multiple types of disease data into a ...
Liang Yu, Shunyu Yao, Lin Gao, Yunhong Zha   +3 more
doaj   +1 more source

Reduction of the chemical master equation for gene regulatory networks using proper generalized decompositions [PDF]

, 2012
The numerical solution of the chemical master equation (CME) governing gene regulatory networks and cell signaling processes remains a challenging task owing to its complexity, exponentially growing with the number of species involved.
CHINESTA SORIA, Francisco, Chinesta, Francisco, CUETO, Elias, AMMAR, Amine   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Genes related to maintenance of autophagy and successful aging

Arquivos de Neuro-Psiquiatria
Considering aging as a phenomenon in which there is a decline in essential processes for cell survival, we investigated the autophagic and proteasome pathways in three different groups: young, older and oldest old male adults.
Carolina Fioroto Chaves, Diego Robles Mazzotti, Maysa Seabra Cendoroglo, Luiz Roberto Ramos, Sergio Tufik, Vanessa Cavalcante da Silva, Vânia D'Almeida   +6 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Analysis of Human Papillomavirus-Associated Cervical Cancer Differentially Expressed Genes and Identification of Prognostic Factors using Integrated Bioinformatics Approaches

Advanced Biomedical Research
Background: Human papillomavirus (HPV)-induced cervical cancer progresses through a series of steps. Despite our limited understanding of the mechanisms driving this progression, identifying the key genes involved could significantly improve early ...
Saba Hatefi-Shogae, Modjtaba Emadi-Baygi, Rasoul Ghaedi-Heydari   +2 more
doaj   +1 more source

Detection of Regulator Genes and eQTLs in Gene Networks [PDF]

, 2016
minor revision with typos corrected; review article; 24 pages, 2 ...
Wang, Lingfei, Michoel, Tom
openaire   +2 more sources