Results 41 to 50 of about 5,894,586 (297)

Integrative Analysis Reveals Across-Cancer Expression Patterns and Clinical Relevance of Ribonucleotide Reductase in Human Cancers

Frontiers in Oncology, 2019
Mining cancer-omics databases deepens our understanding of cancer biology and can lead to potential breakthroughs in cancer treatment. Here, we propose an integrative analytical approach to reveal across-cancer expression patterns and identify potential ...
Yongfeng Ding, Yongfeng Ding, Yongfeng Ding, Tingting Zhong, Tingting Zhong, Tingting Zhong, Min Wang, Xueping Xiang, Xueping Xiang, Guoping Ren, Zhongjuan Jia, Qinghui Lin, Qian Liu, Jingwen Dong, Linrong Li, Xiawei Li, Haiping Jiang, Lijun Zhu, Haoran Li, Dejun Shen, Lisong Teng, Chen Li, Jimin Shao, Jimin Shao   +23 more
doaj   +1 more source

Network modelling of gene regulation [PDF]

Biophysical Reviews, 2010
Gene regulatory network (GRN) modelling has gained increasing attention in the past decade. Many computational modelling techniques have been proposed to facilitate the inference and analysis of GRN. However, there is often confusion about the aim of GRN modelling, and how a gene network model can be fully utilised as a tool for systems biology.
Joshua W K, Ho, Michael A, Charleston
openaire   +2 more sources

The potential clinical impact of cell type‐specific genetic regulation: Crohn's disease

Clinical and Translational Medicine, 2023
Complex diseases are heterogenous due to variation in their genetic and environmental underpinnings, leading to varied treatment responses. Genome‐wide association studies (GWAS) integrated with single‐cell expression quantitative trait loci analyses ...
Rika Tyebally, Angli Xue, Joseph E. Powell   +2 more
doaj   +1 more source

Bioinformatics benefits from Siberia: on the anniversary of Nikolay Aleksandrovich Kolchanov, Academician of the Russian Academy of Sciences (RAS)

Биотехнология и селекция растений, 2022
January 9, 2022 marks the 75th anniversary of Nikolai Aleksandrovich Kolchanov, Doctor of Biological Sciences, Professor, Academician of the Russian Academy of Sciences, Scientific Leader of the Federal Research Center the Institute of Cytology and ...
E. K. Khlestkina, A. A. Nizhnikov, I. A. Tikhonovich   +2 more
doaj   +1 more source

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Innovative Hybridisation of Genetic Algorithms and Neural Networks in Detecting Marker Genes for Leukaemia Cancer [PDF]

, 2009
Methods for extracting marker genes that trigger the growth of cancerous cells from a high level of complexity microarrays are of much interest from the computing community.
Mintram, Robert, Phalp, Keith T., Schierz, Amanda C., Tong, Dong L.   +3 more
core   +6 more sources

Regulation and dysregulation of microRNA - transcription factor axes in differentiation and neuroblastoma

Cellular and Molecular Life Sciences
Development is characterized by dynamic changes in gene expression as cells traverse genetic pathways and make lineage-specific commitments. Transcription factors, which drive gene expression, and microRNAs, the largest class of post-transcriptional ...
Fakhira H. Nazki, Cameron P. Bracken
doaj   +1 more source

Gene networks for use in metabolomic data analysis of blood plasma from patients with postoperative delirium

Вавиловский журнал генетики и селекции, 2023
Postoperative delirium (POD) is considered one of the most severe complications, resulting in impaired cognitive function, extended hospitalization, and higher treatment costs.
V. A. Ivanisenko, N. V. Basov, A. A. Makarova, A. S. Venzel, A. D. Rogachev, P. S. Demenkov, T.  V. Ivanisenko, M. A. Kleshchev, E. V. Gaisler, G. B. Moroz, V. V. Plesko, Y. S. Sotnikova, Y. V. Patrushev, V. V. Lomivorotov, N. A. Kolchanov, A. G. Pokrovsky   +15 more
doaj   +1 more source

Correlated fluctuations carry signatures of gene regulatory network dynamics [PDF]

, 2010
The dynamics of transcriptional control involve small numbers of molecules and result in significant fluctuations in protein and mRNA concentrations.
Pakka, V. H., Pakka, Vijayanarasimha H., Prugel-Bennett, Adam, Prugel-Bennett, A., Adam Prügel-Bennett, Dasmahapatra, S., Pakka, Vijayanarasimha, Dasmahapatra, Srinandan, Vijayanarasimha H. Pakka, Srinandan Dasmahapatra   +9 more
core   +1 more source

Neurocognitive, School‐Based, and Quality of Life Outcomes for Youth With Sickle Cell Disease and Thalassemia: A Scoping Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The medical burdens of sickle cell disease (SCD) and transfusion‐dependent β‐thalassemia (TDT) are chronic and cumulative, even in children. Yet the effects expand beyond medications and healthcare visits due to their impacts on school attendance, academic performance, and peer engagement.
Mary Ann Etling, Hakim Tokhi, Alexander A. Boucher   +2 more
wiley   +1 more source