Results 201 to 210 of about 123,439 (272)

Codeine toxicity via breast Milk: Can this occur and implications for opiate therapy in children

British Journal of Clinical Pharmacology, EarlyView.
Codeine is commonly used in combination analgesic products. The use of codeine during breastfeeding can rarely be associated with serious adverse effects related to genetic polymorphisms affecting codeine's metabolism and disposition. Clinicians treating infants of breastfeeding mothers should be aware of this rare but potentially serious complication.
Michael Rieder
wiley   +1 more source

Brain Proteomic Responses to Glucocorticoids and Their Relationship With Transcriptome: A Systematic Meta-Analysis. [PDF]

FASEB J
Juszczak GR.
europepmc   +1 more source

First‐in‐human, phase I, randomized, safety, pharmacokinetic, food‐effect and pharmacodynamic study of a tyrosine kinase 2/Janus kinase 1 inhibitor, SDC‐1801

British Journal of Clinical Pharmacology, EarlyView.
Aim The purpose of this study is to evaluate safety, tolerability, pharmacokinetics (PK), food‐effect (FE) and pharmacodynamics (PD) of an oral tyrosine kinase‐2 (TYK2)/Janus kinase‐1 (JAK1) inhibitor, SDC‐1801, in healthy adult participants. Methods This first‐in‐human study randomized 95 male and female participants.
Chris Brearley, Sam Francis, John Reader, Judi Proctor   +3 more
wiley   +1 more source

<i>Bacillus toyonensis</i> biovar Thuringiensis: an overlooked entomopathogen? [PDF]

J Bacteriol
Sauka DH, Peralta C, Del Valle EE, Palma L.   +3 more
europepmc   +1 more source

Lost and found in translation: the value of the human imiquimod model

British Journal of Clinical Pharmacology, EarlyView.
Topical imiquimod (IMQ), a Toll‐like receptor (TLR) 7 agonist, induces transient cutaneous inflammation and is widely used in preclinical research as a ‘psoriasis‐like’ mouse model. However, accumulating evidence indicates substantial divergence between IMQ‐driven biology and human plaque psoriasis pathogenesis.
Anouk C. Meijs, Juliette A. van den Noort, Salma Assil, Naomi B. Klarenbeek, Matthijs Moerland, Tessa Niemeyer‐van der Kolk, Robert Rissmann   +6 more
wiley   +1 more source

Nomenclature for Tracking of Genetic Variation of Seasonal Influenza Viruses. [PDF]

Influenza Other Respir Viruses
Neher RA, Huddleston J, Bedford T, Lewis NS, Harvey R, Galiano M, Byrne AMP, James S, Smith D, Łuksza M, Ruchnewitz D, Laessig M, Fujisaki S, Watanabe S, Hasegawa H, Hassell N, Wentworth DE, Kondor R, Deng YM, Dapat C, Subbarao K, Barr I.   +21 more
europepmc   +1 more source

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, EarlyView.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

Improving the learning experience in an undergraduate course on microbial metabolism by using an illustrated story

Biochemistry and Molecular Biology Education, Volume 53, Issue 2, Page 131-141, March/April 2025.
Abstract In the classroom, metabolism is often approached and received as a mundane exercise in memorization. Teaching metabolism also faces the challenge of negative perceptions that can impede learning. We sought to improve the learning experience in an undergraduate lecture course on microbial metabolism by implementing an illustrated story that ...
James B. McKinlay, Katherine Kearns
wiley   +1 more source

Transformative Service Ecosystems for People, Plants, Place, Planet, and Prosperity: A Sustainable Operations Management Perspective

Biological Diversity, EarlyView.
The Transformative Service Ecosystem for Sustainable Operations Management (TSESOM) model reframes operations management as a co‐creative ecosystem shaped by philosophical foundations and macro–meso–micro contexts. Integrating governance, resilience, learning, systems thinking, and interdisciplinary collaboration, TSESOM advances regenerative SDG‐ and ...
Nicholas Catahan
wiley   +1 more source

Life Identification Numbers: A strain nomenclature approach to aid epidemiological surveillance of bacterial pathogens. [PDF]

PLoS Biol
Palma F, Hennart M, Jolley KA, Crestani C, Wyres KL, Bridel S, Yeats CA, Brancotte B, Raffestin B, David S, Lam MMC, Izdebski R, Passet V, Rodrigues C, Rethoret-Pasty M, Combary A, Cottis S, Maiden MCJ, Aanensen DM, Holt KE, Criscuolo A, Brisse S.   +21 more
europepmc   +1 more source