Results 51 to 60 of about 3,153,117 (306)

Polymorphism of human CD1 genes [PDF]

Tissue Antigens, 1999
Human CD1 genes have been reported to be invariant or to show limited polymorphism. Recently, certain functions of CD1 antigens have been described to include the presentation lipid and glycolipid antigens. These observations prompted a thorough survey of the genetic polymorphism in the five human CD1 genes (CD1a–CD1e).
Han, M., Hannick, L. I., DiBrino, M., Robinson, M. A.   +3 more
openaire   +3 more sources

Investigation of host candidate malaria-associated risk/protective SNPs in a Brazilian Amazonian population. [PDF]

, 2012
The Brazilian Amazon is a hypo-endemic malaria region with nearly 300,000 cases each year. A variety of genetic polymorphisms, particularly in erythrocyte receptors and immune response related genes, have been described to be associated with ...
Rockett, Kirk A., Campino Susana, Martha Cecília Suarez-Mutis, Martha Cecília Suarez-Mutis (164115), Simone da Silva Santos, Santos, Simone da Silva, Fernandes, Octavio, Dominic P. Kwiatkowski (106264), Susana Campino, Kirk A Rockett, Kirk A. Rockett (138127), Rockett, Kirk A, Octavio Fernandes (16216), Dominic P Kwiatkowski, Kwiatkowski Dominic P., Taane G Clark, Campino, Susana, da Silva Santos Simone, Taane G. Clark (106263), Susana Campino (56411), Clark, Taane G., Rockett Kirk A., Suarez-Mutis, Martha Cecília, Clark Taane G., Octavio Fernandes, Simone da Silva Santos (164105), Kwiatkowski, Dominic P., Suarez-Mutis Martha Cecília, da Silva Santos, Simone, Clark, Taane G, Kwiatkowski, Dominic P, Fernandes Octavio   +31 more
core   +1 more source

Endothelial nitric oxide synthase genotype and ischemic heart disease: meta-analysis of 26 studies involving 23028 subjects [PDF]

, 2004
Background: Polymorphisms in the endothelial nitric oxide synthase (eNOS) gene may influence the risk of ischemic heart disease (IHD), but data from published studies with individually low statistical power are conflicting.
Humphries, S.E., Bautista, Leonelo E, Humphries, Steve E, Bautista, L.E., Casas, J.P., Hingorani, Aroon D, Casas, Juan P, Hingorani, A.D., J. P. Casas   +8 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Polymorphism of the ovine calpastatin gene

Molecular and Cellular Probes, 2007
Calpastatin is a specific inhibitor of calpains and has been implicated in the regulation of beef tenderization. Variation in the ovine calpastatin gene (CAST) was investigated by amplification of a fragment containing the entire exon 6 using polymerase chain reaction (PCR), followed by single-strand conformational polymorphism (PCR-SSCP) analysis and ...
H, Zhou, J G H, Hickford, H, Gong
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

The role of gene polymorphisms in endometriosis

Molecular Medicine Reports, 2017
Endometriosis is a benign gynecologic disorder, affecting up to 10% of women, characterized by the presence of functional endometrial tissue at ectopic positions generally within the peritoneum. It is a heritable condition influenced by multiple genetic and environmental factors, with an overall heritability estimated at approximately 50%.
Matalliotakis, M, Zervou, M, Matalliotaki, C, Rahmioglu, N, Koumantakis, G, Kalogiannidis, I, Prapas, I, Zondervan, K, Spandidos, D, Matalliotakis, I, Goulielmos, G   +10 more
openaire   +3 more sources

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source