Results 31 to 40 of about 5,248,714 (172)

Hyper-responsiveness to Stimulation of Human Immunodeficiency Virus-infected CD4+ T Cells Requires Nef and Tat Virus Gene Products and Results from Higher NFAT, NF-κB, and AP-1 Induction [PDF]

Journal of Biological Chemistry, 2004
A chronic state of immune hyperactivation is a feature of human immunodeficiency virus type-1 (HIV-1) infection. Studies on the molecular mechanisms by which HIV-1 can modulate the activation state of T cells indicate that both Nef and Tat can alter T cell activation.
Jean-François, Fortin, Corinne, Barat, Yannick, Beauséjour, Benoit, Barbeau, Michel J, Tremblay   +4 more
openaire   +2 more sources

Roles of phosphatidylserine exposed on the viral envelope and cell membrane in HIV-1 replication

Cell Communication and Signaling, 2019
Phosphatidylserine (PtdSer) is usually present only in the inner leaf of the lipid bilayers of the cell membrane, but is exposed on the outer leaf when cells are activated and/or die. Exposure of PtdSer has physiological functions.
Bernadette Anne Chua, Jamie Ann Ngo, Kathy Situ, Kouki Morizono   +3 more
doaj   +1 more source

Nef-containing exosomes deliver Nef to macrophages.

, 2019
A—Size distribution of the extracellular vesicles secreted by HEK293 cells determined by EM; Inset–EM micrograph of the vesicles; bar– 200 nm. B—Western blot for the exosomal marker Alix and Nef in cells and exosomes (exNef); C—Western blot for the ...
Ryunosuke Ohkawa (514009), Andrew Murphy (341397), Hann Low (6612692), Peter J. Meikle (54253), Dmitri Sviridov (54259), Michael Ditiatkovski (432029), Yury I. Miller (181644), Ying Fu (173963), Nigora Mukhamedova (54252), Tatiana Pushkarsky (363651), Michael Bukrinsky (45092), Beda Brichacek (361586), Dragana Dragoljevic (7042715), Larisa Dubrovsky (45091), Anelia Horvath (444445), Anh Hoang (6612695)   +15 more
core   +1 more source

Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis [PDF]

, 2010
Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic ...
S Eyre, J Worthington, X Ke, P Martin, W Thomson, A Hinks, E Flynn, J Packham, A Barton, Martin, P., Barton, A., Gardner-Medwin, J. [CAPS and BSPAR study groups], UKRAG Consortium, Worthington, J., Thomson, W., Flynn, E., Packham, J., Hinks, A., British Society of Paediatric and Adolescent Rheumatology (BSPAR) Study Group, Eyre, S., Ke, X., Childhood Arthritis Prospective Study (CAPS)   +21 more
core   +1 more source

Identification of cellular proteins that bind to the human immunodeficiency virus type 1 nef gene product in vitro: a role for myristylation

Journal of General Virology, 1993
The human immunodeficiency virus (HIV) type 1 nef gene product was expressed as an N-terminal fusion protein with glutathione-S-transferase (GST) in the baculovirus system. The resulting nefGST fusion protein was found to be authentically myristylated at the N terminus and could be purified to homogeneity by one-step affinity chromatography on ...
M, Harris, K, Coates
openaire   +2 more sources

Functional variation in butterfly egg pore traits: The potential role of climate

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Immobile eggs of terrestrial animals are exposed to variable environmental conditions. Insect egg pores, critical for gas exchange (aeropyles) and fertilisation (micropyles), are ecologically important yet understudied.
Teun de Jong, Liana O. Greenberg, Ella Catley, Nina E. Fatouros, Graziella Iossa   +4 more
wiley   +1 more source

S6_Data from Nef et al.

, 2022
S6 Data from the publication of Nef et al. in PLOS Biology entitled "Whole-genome scanning reveals environmental selection mechanisms that shape diversity in populations of the epipelagic diatom Chaetoceros".
Nef, Charlotte, Madoui, Mohammed-Amin, Pelletier, Éric, Bowler, Chris   +3 more
core   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

Nef-isocyanide-Perkow access to novel pyrazolone derivations containing a cyclic ketene dithioacetal moiety

, 2019
Alkyl (E)-2-(3-Alkyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)-5-(alkylamino)-1,3-dithiole-4-carboxylates have been obtained by condensation of 2-pyrazolin-5-ones with carbon disulfide followed by ring formation with phosphorylated ...
Issa Yavari (657967), Mohammad Reza Halvagar (1929790), Jamil Sheykhahmadi (5842931), Hamed Saffarian (4231663)   +3 more
core   +1 more source