Results 51 to 60 of about 5,248,714 (172)

The Human Immunodeficiency Virus Type 1 nef Gene Can to a Large Extent Replace Simian Immunodeficiency Virus nef In Vivo

, 1999
The nef gene of the pathogenic simian immunodeficiency virus (SIV) 239 clone was replaced with primary human immunodeficiency virus type 1 (HIV-1) nef alleles to investigate whether HIV-1 Nef can ...
Kirchhoff, Frank, Skowronski, Jacek, Carl, Silke, Fuchs, Dietmar, Heeney, Jonathan L., Münch, Jan, Stolte, Nicole, Stahl-Hennig, Christiane, Mätz-Rensing, Kerstin, Ten Haaft, Peter, Swigut, Tomek   +10 more
core   +1 more source

Enhancing HIV-1 Nef Penetration into Mammalian Cells as an Antigen Candidate

Journal of Medical Microbiology and Infectious Diseases, 2019
Introduction: The human immunodeficiency virus type 1 (HIV-1) Nef regulatory protein is known as a candidate for the design of therapeutic HIV DNA and protein vaccines.
Saba Davoodi, Azam Bolhassani, Seyed Mehdi Sadat, Shiva Irani   +3 more
doaj  

Focus on DnaJ protein research from Arabidopsis to crop improvement

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract DnaJ proteins (Hsp40s) are essential components of the cellular proteostasis network, functioning as molecular co‐chaperones that regulate protein folding, stability, and stress‐responsive homeostasis in plants. Beyond their classical role as Hsp70 partners, accumulating evidence demonstrates that DnaJ proteins participate in diverse ...
Muhammad Arif, Hafiz Mamoon Rehman, Sehrish Bashir, Noman Mahmood, Atul Kumar Srivastava, Yakov Kuzyakov, Moh Sajid Ansari, Hon‐Ming Lam, Mingfang Yang   +8 more
wiley   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti, Elisa Patacchini, Emanuele Cara, Laura Zarbo, Antonella Messore, Aurora Albano, Giuseppe Ruggieri, Valentina Noemi Madia, Luigi Scipione, Roberta Costi, Roberto Di Santo   +10 more
wiley   +1 more source

Isabelle Nef, Harpischordist and the University Sinfonietta, December 28, 1963 [PDF]

, 1963
Concert program for Isabelle Nef, Harpischordist and the University Sinfonietta, December 28 ...

core  

Endochitinase Overexpression in Transgenic Tomato Plants Improves Resistance to Phytopathogens

Biotechnology Journal, Volume 21, Issue 8, August 2026.
Graphical Abstract and Lay Summary Transgenic tomato plants overexpressing an endochitinase gene showed confirmed transgene expression and enhanced resistance. Upon plants inoculations with Xanthomonas euvesicatoria pv. perforans and Sclerotinia sclerotiorum, disease severity was significantly reduced compared to wild‐type plants, demonstrating broad ...
Lucas José de Sousa, Ana Carolina Mendes Bezerra, Ivonaldo Reis Santos, Ana Clara Muniz Martins Vilela, Osmundo Brilhante de Oliveira Neto, Glaucia Barbosa Cabral, Alice Maria Quezado‐Duval, Pedro Ricardo Vieira Hamann, Eliane Ferreira Noronha, Luiz Eduardo Bassay Blum, Angela Mehta   +10 more
wiley   +1 more source

Single‐Nucleus Multiomic Analysis Reveals Immune–Metabolic Reprogramming Consistent With Maladaptive Trained Immunity in HIV‐Associated Neurocognitive Disorders

Glia, Volume 74, Issue 8, August 2026.
Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez, Anelia Horvath, Luke Johnson, Tatiana Pushkarsky, Larisa Dubrovsky, Daria Starosyla, Ashley Bastin, Dmitri Sviridov, Michael Bukrinsky   +8 more
wiley   +1 more source

Contrasting population genetic structures of congeneric coastal flounders associated with different early life histories

Journal of Fish Biology, Volume 109, Issue 2, Page 1141-1159, August 2026.
Abstract Marine fish species are likely to exhibit little genetic differentiation among populations due to their high dispersal potential during early life stages and migratory nature. However, recent studies have increasingly reported intraspecific genetic differentiation resulting from species‐specific ecological traits, environmental factors, and ...
Yuki Yamamoto, Hiroyuki Togashi, Yutaka Kurita, Satoshi Katayama, Yoshiaki Akaba, Mitsuhiro Ishii, Tatsuya Isshiki, Minoru Ikeda   +7 more
wiley   +1 more source

Characterization of products of projective spaces via nef complexity

We define the nef complexity of a projective variety $X$. This invariant compares $\dim X+ρ(X)$ with the sum of the coefficients of nef partitions of $-K_X$.
Yoshinori Gongyo, Roberto Svaldi, Joshua Enwright, Kiwamu Watanabe, Joaquín Moraga, Stefano Filipazzi, Chengxi Wang   +6 more
core   +1 more source

Inbreeding in a Fission–Fusion Equid Decreases Following an Increase in the Number and Redistribution of Water Sources

Molecular Ecology, Volume 35, Issue 16, August 2026.
ABSTRACT Social structures and habitat configuration influence inbreeding in wild populations. In harem‐forming, female‐defence polygynous equids, social organization promotes inbreeding avoidance, but this has not been studied in fission–fusion, resource‐defence equid species.
Noa Yaffa Kan‐Lingwood, Alan R. Templeton, Naama Shahar, Daniel I. Rubenstein, Amos Bouskila, Shirli Bar‐David   +5 more
wiley   +1 more source