Results 61 to 70 of about 5,248,714 (172)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, Volume 600, Issue 14, Page 2028-2037, July 2026.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Evolution of the HIV-1 nef gene in HLA-B*57 Positive Elite Suppressors

, 2010
Elite controllers or suppressors (ES) are HIV-1 infected patients who maintain viral loads of gag and nef in HLA-B*57 positive ES. We previously showed evolution in the gag gene of ES which surprisingly was mostly due to synonymous mutations rather than ...
O'Connell Karen A, Brennan Timothy P, Blankson Joel N, Robert F Siliciano, Bailey Justin R, Timothy P Brennan, Maria Salgado, Justin R Bailey, Siliciano Robert F, Stuart C Ray, Joel N Blankson, Ray Stuart C, Salgado Maria, Karen A O'Connell   +13 more
core   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, Volume 16, Issue 7, Page 1293-1304, July 2026.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

varioustoxins/NEF-Pipelines: 0.1.65

<h1>NEF-Pipelines</h1> <p>A set of command line (currently... there maybe a gui later!) tools for maniulating [NEF] or NMR Exchange Format files which can be used to move NMR meta data [peaks, shifts, sequences etc] between NMR data ...
varioustoxins, locsmith, gweatherby
core   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, Volume 13, Issue 42, 28 July 2026.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Mechanism and mediated mechanistic analysis of HIV Nef [PDF]

, 2004
The nef gene of HIV is required for complete viral pathogenicity. As an accessory gene with no known paradigm its principle function has been enigmatic.
Simmons, Alison
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, Volume 13, Issue 38, 9 July 2026.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Association of the CCR5 gene with juvenile idiopathic arthritis [PDF]

, 2010
The CC chemokine receptor 5 (CCR5) has been shown to be important in the recruitment of T-helper cells to the synovium, where they accumulate, drive the inflammatory process and the consequent synovitis and joint destruction.
Martin, P., BSPAR Study Group, Barton, A., UKRAG Consortium, Worthington, J., Gardner-Medwin, J. [CAPS and BSPAR Study Groups], Thomson, W., W Thomson, Flynn, E., A Hinks, E Flynn, J Packham, Packham, J., Hinks, A., S Eyre, J Worthington, Eyre, S.; id_orcid, Eyre, S., Barton, A.; id_orcid, P Martin, Childhood Arthritis Prospective Study (CAPS), Martin, P.; id_orcid, A Barton   +22 more
core   +1 more source

Genetic switching during protein synthesis and the role of quadruplexes in HIV-1’s nef gene [PDF]

, 2018
HIV-1 is still a prominent global public health issue responsible for the deaths of over 1 million people annually. It is a very complex virus that has been extensively studied over the past decade.
Cochran, Steven Nicholas, NC DOCKS at The University of North Carolina at Greensboro   +1 more
core  

Histopathological and cognitive defects induced by Nef in the brain

, 2004
International audienceComplex mechanisms of human immunodeficiency virus type-1 (HIV-1) brain pathogenesis suggest the contribution of individual HIV-1 gene products.
Catherine Vidal, Pierre Charneau, Ozden, Simona, Francoise Gray, Karima Kissa, Arnaud Cressant, Simona Ozden, Vidal, Catherine, Kissa, Karima, Gray, Françoise, Mordelet, Elodie, Elodie Mordelet, Sylvie Granon, Cressant, Arnaud, Charneau, Pierre, Granon, Sylvie   +15 more
core   +1 more source