Results 41 to 50 of about 5,248,714 (172)

Heat Shock Protein 40 is necessary for Human Immunodeficiency Virus-1 Nef-mediated enhancement of viral gene expression and replication [PDF]

, 2005
The human immunodeficiency virus-1 (HIV-1) Nef protein, originally identified as a negative factor, has now emerged as one of the most important viral proteins necessary for viral pathogenesis and disease progression.
Kumar, Manish, Mitra, Debashis
core   +1 more source

Lytic reactivation of EBV by HIV proteins and antiretroviral therapy with the heightened expression of MEF-2 oncogenes implicated in AIDS-related cancer

The Microbe
Despite effective antiretroviral therapy (ART), people living with HIV (PLWH) remain at a higher risk of developing AIDS-related cancers. The factors attributed to this increased risk are multifactorial, including long-term ART use, prolonged exposure to
Alesha Philip, Thomas A. Premeaux, Adhikarimayum Lakhikumar Sharma, Cabirou Mounchili Shintouo, Aykan Karabudak, Liudi Tang, Salwa Ahmed, Alekhya Rani Chunduri, Sai Chaitanya R. Gaekwar, Elias Haddad, Ryan Hoffmann, Mudit Tyagi, Pooja Jain   +12 more
doaj   +1 more source

Molecular Chaperone Networks in Plants: Maintaining Proteostasis and Enhancing Stress Resilience for Crop Improvement

Plant, Cell &Environment, EarlyView.
ABSTRACT Molecular chaperones play a central role in the plant proteostasis machinery by aiding the folding of nascent proteins, preventing aggregation, and repairing or degrading damaged proteins. These functions are especially essential during abiotic and biotic stress, which can destabilise cellular proteins and disrupt metabolic homoeostasis.
Mingfang Yang, Anqin Gao, Tsz‐Yan Chan, Hafiz Mamoon Rehman, Sehar Nawaz, Sehrish Bashir, Noman Mahmood, Muhammad Wajid Ullah, Chunlin Long, Hon‐Ming Lam, Muhammad Arif   +10 more
wiley   +1 more source

The Chaetocerosphere: Chaetoceros Species and Associated Prokaryotes in a Coastal Area

Environmental Microbiology Reports, Volume 18, Issue 5, October 2026.
Chaetoceros species maintain recurrent distinct prokaryotic assemblages in their phycosphere. Alphaproteobacteria, Bacteroidetes and Archaea Thermoplasmata and Marine Group II are the most represented in the phycosphere. Bipartite networks highlight strong links between the diatom and specific prokaryotic taxa, especially the chain‐forming species ...
Anna Chiara Trano, Raffaella Casotti, Roberta Piredda   +2 more
wiley   +1 more source

A hybrid lentivirus-transposon vector for safer gene therapy [PDF]

, 2010
Gene therapy vectors based on the HIV-1 lentivirus are an attractive option for clinical applications because they enter a broad range of target cells efficiently and deliver stable gene expression through integration into host chromosomes.
Vink, C.A.
core  

Nonpathogenic SIV Infection in Sooty Mangabeys Is Characterized by a Lack of Activation and Expansion of Monocytes

Journal of Medical Primatology, Volume 55, Issue 5, October 2026.
ABSTRACT Introduction Natural hosts of simian immunodeficiency virus (SIV), including sooty mangabeys (SMs), maintain high viremia without progressing to AIDS and AIDS‐associated histopathogenesis. The mechanisms underlying this protection and lack of pathogenesis remain incompletely understood, particularly in relation to monocyte/macrophage ...
Caroline Soulas, Hai Duc Nguyen, Summer Siddiqui, Natalie Stahr, Tricia H. Burdo, Francis J. Novembre, Woong‐Ki Kim, Kenneth C. Williams   +7 more
wiley   +1 more source

Identification of a Novel Small Molecule Facilitating HIV Elimination by the “Shock‐And‐Kill” Approach

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Antiretroviral therapy (ART) has markedly improved the prognosis of people living with HIV (PLWH); however, latent viral reservoirs remain a major barrier to a cure. The “Shock and Kill” strategy aims to reactivate latent provirus with latency‐reversing agents (LRAs) and subsequently eliminate the infected cells, yet most LRAs characterized to
Yuichiro Hara, Haruki Kitamura, Kouki Matsuda, Chieko Fujisaki, Sayaka Sukegawa, Kosuke Tanimoto, Kenji Maeda, Hiroaki Takeuchi   +7 more
wiley   +1 more source

S10_S17_Data from Nef et al.

, 2022
Supplementary Data from the publication of Nef et al. in PLOS Biology entitled "Whole-genome scanning reveals environmental selection mechanisms that shape diversity in populations of the epipelagic diatom Chaetoceros". S10 Data.
Nef, Charlotte, Madoui, Mohammed-Amin, Pelletier, Éric, Bowler, Chris   +3 more
core   +1 more source

Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting

MedComm, Volume 7, Issue 9, September 2026.
This review illustrates heat shock proteins (HSPs) as central regulators of cancer metabolic reprogramming. By stabilizing key metabolic enzymes and coordinating glycolysis, oxidative phosphorylation, redox homeostasis, and stress adaptation, HSPs support tumor growth, metastasis, and therapeutic resistance. Targeting HSP networks may therefore provide
Sheng Ma, Chen‐Qian Liu, Si‐Yang Ma, Shao‐Gang Wang, Qi‐Dong Xia, Meng‐Yao Xu   +5 more
wiley   +1 more source

Graded traumatic brain injury severity differentially modulates microglial and astrocytic polarization states and response to minocycline

Neuroprotection, Volume 4, Issue 3, Page 275-294, September 2026.
Schematic diagram of the experimental design and key findings of traumatic brain injury (TBI) with varying severities. Mild, moderate, and severe TBI were induced in the right motor cortex of mice using the controlled cortical impact (CCI) method, with impact depths of 0.5, 1.0, and 2.0 mm, respectively. A subset of severe TBI mice received minocycline
Yan Yu, Chen Wang, Jinyu Zhu, Jiahui Du, Hao Li, Shuyi Ning, Rui Yang, Yiwen Ma, Mengyuan Yuan, Wei Shen, Huailin Wang, Huihui Jiang, Liping Chen, Haitao Wu   +13 more
wiley   +1 more source