Results 41 to 50 of about 9,406 (131)

A Syndecan‐Based Genetic Approach to Coat the Surface of Small Extracellular Vesicles With Nanobodies

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Small extracellular vesicles (sEVs) are promising vehicles for targeted therapeutic delivery, but strategies for their surface functionalization remain limited. Here, we present a reliable and simple genetic approach that enables customized modification of sEV surfaces and supports enhanced sEV uptake by recipient cells. This strategy is based
Lukas Hyka, Sofie Meeussen, Rania Ghossoub, Michiel De Coster, Elke De Bruyne, Guido David, Patrick Chames, Pascale Zimmermann   +7 more
wiley   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

ATP modulates holdase activity of fungal and human 110‐kilodalton heat shock proteins to promote protein folding

Protein Science, Volume 35, Issue 5, May 2026.
Abstract Heat shock proteins of the 70‐kDa family (Hsp70s) are highly abundant and conserved molecular chaperones that help preserve proteostasis primarily by facilitating proper protein folding. Heat shock protein of the 110‐kDa family (Hsp110s), a specialized branch of the Hsp70/Hsp110 superfamily, function both as nucleotide exchange factor (NEF ...
Justin M. Kidd, Cancan Sun, Alissa Garay, Mitchell Keplinger, Colin Richter, Aaron E. May, Qinglian Liu   +6 more
wiley   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Oral Presentation

European Journal of Neurology, Volume 33, Issue S1, June 2026.
wiley   +1 more source

Replication-competent SIVcpz CRISPR screen identifies barriers to successful cross-species transmission. [PDF]

J Virol
Xie Q, Wang Q, Noettger S, Gosálbez G, Betzler AC, Volcic M, Kmiec D, Krebs S, Graf A, Gülensoy D, Weidinger G, Sparrer KMJ, Kirchhoff F.   +12 more
europepmc   +2 more sources

Molecular Mechanisms Underlying the Anti-Tumor Activity of Lotus-Derived Alkaloids in Breast Cancer. [PDF]

Molecules
He Q, Luo L, Zhang D, Zhou W, Bai N, Du C, Li S.   +6 more
europepmc   +1 more source

HIV Nef-mediated WAVE2-ARP2/3 inhibition underlies CD4⁺ T-cell lamellipodial abnormalities and immune dysfunction. [PDF]

mBio
Dunn DC, Crater JM, Del Río Estrada PM, Malgady JM, Haas G, Klain W, Torres-Ruiz MF, Luna-Villalobos YA, González-Navarro M, Kang C, Kovacs C, Ávila-Ríos S, Lee B, Jolicoeur P, Nixon DF, Furler O'Brien RL.   +15 more
europepmc   +1 more source

Designing universal T cell therapies: strategies to evade natural killer cells. [PDF]

Front Immunol
Bushara O, Linette GP, Carreno BM.
europepmc   +1 more source

Neferine inhibits vascular smooth muscle cell proliferation and migration in atherosclerosis by targeting CYS130 and PHE252 in PTEN. [PDF]

Front Pharmacol
Jin Q, Liu Q, Ruan C, Xie Z, Gao X, Jiang Y, Jiang F, Xie B.   +7 more
europepmc   +1 more source