Integrative genomic and immunoinformatic approach for characterizing HIV-1 pol, vpr, and Nef genes and designing a multi-epitope vaccine [PDF]
Scientific ReportsThe study aims to characterize the Pol, Vpr, and Nef genes, as well as to explore the development of vaccines using computational tools. In this study, blood was extracted from HIV-positive samples, followed by RNA extraction.
Akmal Zubair +3 more
doaj +2 more sources
HIV-1 establishes immediate latency in T cells expressing the viral Nef protein. [PDF]
FEBS Open BioNef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Lam C, Sadowski I.
europepmc +2 more sources
Simultaneous efficacy of IL-15 and the HSP70 fragments in increasing immunostimulatory effects of a HIV-1 DNA vaccine candidate against SCR HIV-1. [PDF]
PLoS ONEInterleukin (IL)-15 serves as a potent adjuvant that can enhance T cell-directed vaccine responses. Moreover, heat shock proteins (HSPs) have been used as potent adjuvants in immunotherapy of tumors and infectious diseases, as well as in vaccine ...
Mehrshad Fekri +3 more
doaj +2 more sources
Journal of Ginseng Research, 2017 Background: The presence of gross deletions in the human immunodeficiency virus nef gene (gΔnef) is associated with long-term nonprogression of infected patients.
Young-Keol Cho +2 more
doaj +3 more sources
microRNA-422a promotes HIV replication and innate immune evasion by targeting MECP2 [PDF]
Molecular Therapy: Nucleic AcidsUnderstanding the mechanisms underlying interferon-alpha (IFNα) anti-human immunodeficiency virus type I (HIV-1) effects and HIV-1 innate immune evasion is critical to developing improved antiviral strategies.
Li Du +8 more
doaj +2 more sources
Differential Effects of Human Immunodeficiency Virus Nef Variants on Pulmonary Vascular Endothelial Cell Dysfunction [PDF]
Infectious Disease ReportsBackground: Human Immunodeficiency Virus (HIV) infections remain a source of cardiopulmonary complications among people receiving antiretroviral therapy.
Amanda K. Garcia +9 more
doaj +2 more sources
Molecular factors associated with lung cancer in people living with HIV [PDF]
Brazilian Journal of Infectious DiseasesLung cancer is the most common Non-AIDS-Defining Cancer (NADC) and a leading cause of cancer-related death in People Living With HIV (PLWH). Despite antiretroviral therapy, PLWH are at higher risk of developing cancer compared to the general population ...
Ivonne Denisse Bautista-Rojas +3 more
doaj +2 more sources
The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women [PDF]
Journal of VirologyHIV-1 Nef mediates immune evasion and viral pathogenesis in part through the downregulation of cell surface cluster of differentiation 4 (CD4) and major histocompatibility complex class I (MHC-I) on infected cells.
Sherazaan D. Ismail +13 more
doaj +2 more sources
Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins. [PDF]
PLoS ONE, 2012 HIV-1 Nef protein contributes essentially to the pathology of AIDS by a variety of protein-protein-interactions within the host cell. The versatile functionality of Nef is partially attributed to different conformational states and posttranslational ...
Ellen C Kammula +5 more
doaj +1 more source
The nef gene of simian immunodeficiency virus SIVmac1A11 [PDF]
Journal of Virology, 1992 The role of the simian immunodeficiency virus (SIV) nef gene in viral replication was investigated in several tissue culture systems. SIVmac1A11 is a molecularly cloned virus which replicates in both peripheral blood mononuclear cells (PBMC) and macrophages, although no disease is observed in infected rhesus macaques.
R E, Unger +4 more
openaire +2 more sources