Hsp70 diversification and repurposing across the tree of life: Lessons from the evolutionary and mechanistic trajectory of the Hsp70-Hsp110 chaperone system. [PDF]
FEBS JEvolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Goloubinoff P, Rios PL, Rebeaud ME.
europepmc +2 more sources
Integrative genomic and immunoinformatic approach for characterizing HIV-1 pol, vpr, and Nef genes and designing a multi-epitope vaccine [PDF]
Scientific ReportsThe study aims to characterize the Pol, Vpr, and Nef genes, as well as to explore the development of vaccines using computational tools. In this study, blood was extracted from HIV-positive samples, followed by RNA extraction.
Akmal Zubair +3 more
doaj +2 more sources
Simultaneous efficacy of IL-15 and the HSP70 fragments in increasing immunostimulatory effects of a HIV-1 DNA vaccine candidate against SCR HIV-1. [PDF]
PLoS ONEInterleukin (IL)-15 serves as a potent adjuvant that can enhance T cell-directed vaccine responses. Moreover, heat shock proteins (HSPs) have been used as potent adjuvants in immunotherapy of tumors and infectious diseases, as well as in vaccine ...
Mehrshad Fekri +3 more
doaj +2 more sources
microRNA-422a promotes HIV replication and innate immune evasion by targeting MECP2 [PDF]
Molecular Therapy: Nucleic AcidsUnderstanding the mechanisms underlying interferon-alpha (IFNα) anti-human immunodeficiency virus type I (HIV-1) effects and HIV-1 innate immune evasion is critical to developing improved antiviral strategies.
Li Du +8 more
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Genetic and transcriptomic signatures of host control in HIV-1 infection [PDF]
RetrovirologyBackground The interaction between HIV-1 and the host immune system plays a crucial role in the natural control and progression of the infection. Previous studies have identified APOBEC3G, Tetherin, SAMHD1, and SERINC5 as HIV-1 host restriction factors ...
Sergey Oreshkov +15 more
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Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins. [PDF]
PLoS ONE, 2012 HIV-1 Nef protein contributes essentially to the pathology of AIDS by a variety of protein-protein-interactions within the host cell. The versatile functionality of Nef is partially attributed to different conformational states and posttranslational ...
Ellen C Kammula +5 more
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A Genome-Wide Screen for Machinery Involved in Downregulation of MHC Class I by HIV-1 Nef. [PDF]
PLoS ONE, 2015 The HIV-1-encoded protein, Nef, plays a key role in the development of AIDS. One of Nef's functions is to keep MHC class I off the surface of infected cells, a process that requires the host proteins clathrin and AP-1. To identify other proteins involved
Maja K Choma +3 more
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Infectious Agents and Cancer, 2020 Background Non-Hodgkin lymphoma is of high prevalence among HIV-infected people. In particular, the incidence of HIV-associated Burkitt lymphoma (BL) remains high despite the advent of Highly Active Anti-Retroviral Therapy.
Nontlantla Mdletshe +3 more
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Frontiers in Immunology, 2022 A series of HIV-1 CRF01_AE/CRF07_BC recombinants were previously found to have emerged gradually in a superinfected patient (patient LNA819). However, the extent to which T-cell responses influenced the development of these recombinants after ...
Hui Zhang +30 more
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Evidence of differential HLA class I-mediated viral evolution in functional and accessory/regulatory genes of HIV-1. [PDF]
PLoS Pathogens, 2007 Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures follows generally predictable mutational pathways.
Zabrina L Brumme +16 more
doaj +1 more source