Results 1 to 10 of about 13,075 (222)

Differential Effects of Human Immunodeficiency Virus Nef Variants on Pulmonary Vascular Endothelial Cell Dysfunction [PDF]

Infectious Disease Reports
Background: Human Immunodeficiency Virus (HIV) infections remain a source of cardiopulmonary complications among people receiving antiretroviral therapy.
Amanda K. Garcia, Noelia C. Lujea, Javaria Baig, Eli Heath, Minh T. Nguyen, Mario Rodriguez, Preston Campbell, Isabel Castro Piedras, Edu Suarez Martinez, Sharilyn Almodovar   +9 more
doaj   +3 more sources

HIV-1 establishes immediate latency in T cells expressing the viral Nef protein. [PDF]

FEBS Open Bio
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Lam C, Sadowski I.
europepmc   +2 more sources

Integrative genomic and immunoinformatic approach for characterizing HIV-1 pol, vpr, and Nef genes and designing a multi-epitope vaccine [PDF]

Scientific Reports
The study aims to characterize the Pol, Vpr, and Nef genes, as well as to explore the development of vaccines using computational tools. In this study, blood was extracted from HIV-positive samples, followed by RNA extraction.
Akmal Zubair, Muhammad Ali, Ahmed Al-Emam, Ranya Mohammed Elmagzoub   +3 more
doaj   +2 more sources

Brain transcriptome-wide screen for HIV-1 Nef protein interaction partners reveals various membrane-associated proteins. [PDF]

PLoS ONE, 2012
HIV-1 Nef protein contributes essentially to the pathology of AIDS by a variety of protein-protein-interactions within the host cell. The versatile functionality of Nef is partially attributed to different conformational states and posttranslational ...
Ellen C Kammula, Jessica Mötter, Alexandra Gorgels, Esther Jonas, Silke Hoffmann, Dieter Willbold   +5 more
doaj   +3 more sources

Simultaneous efficacy of IL-15 and the HSP70 fragments in increasing immunostimulatory effects of a HIV-1 DNA vaccine candidate against SCR HIV-1. [PDF]

PLoS ONE
Interleukin (IL)-15 serves as a potent adjuvant that can enhance T cell-directed vaccine responses. Moreover, heat shock proteins (HSPs) have been used as potent adjuvants in immunotherapy of tumors and infectious diseases, as well as in vaccine ...
Mehrshad Fekri, Azam Bolhassani, Monireh Movahedi, Fereshteh Rahmati   +3 more
doaj   +2 more sources

microRNA-422a promotes HIV replication and innate immune evasion by targeting MECP2 [PDF]

Molecular Therapy: Nucleic Acids
Understanding the mechanisms underlying interferon-alpha (IFNα) anti-human immunodeficiency virus type I (HIV-1) effects and HIV-1 innate immune evasion is critical to developing improved antiviral strategies.
Li Du, Jean-Noël Billaud, Sushama Telwatte, Nikhila Kadiyala, Prerna Dabral, Mohamed S. Bouzidi, John Guatelli, Steven A. Yukl, Satish K. Pillai   +8 more
doaj   +2 more sources

The role of Nef in the long-term persistence of the replication-competent HIV reservoir in South African women [PDF]

Journal of Virology
HIV-1 Nef mediates immune evasion and viral pathogenesis in part through the downregulation of cell surface cluster of differentiation 4 (CD4) and major histocompatibility complex class I (MHC-I) on infected cells.
Sherazaan D. Ismail, Shorok Sebaa, Bianca Abrahams, Martha C. Nason, Mitchell J. Mumby, Jimmy D. Dikeakos, Sarah B. Joseph, Matthew Moeser, Ronald Swanstrom, Nigel Garrett, Carolyn Williamson, Thomas C. Quinn, Melissa-Rose Abrahams, Andrew D. Redd   +13 more
doaj   +2 more sources

Molecular factors associated with lung cancer in people living with HIV [PDF]

Brazilian Journal of Infectious Diseases
Lung cancer is the most common Non-AIDS-Defining Cancer (NADC) and a leading cause of cancer-related death in People Living With HIV (PLWH). Despite antiretroviral therapy, PLWH are at higher risk of developing cancer compared to the general population ...
Ivonne Denisse Bautista-Rojas, Jesus Figueroa-Navarrete, Diana Laura Reyes-Hernandez, Evelyn Rivera-Toledo   +3 more
doaj   +2 more sources

A Genome-Wide Screen for Machinery Involved in Downregulation of MHC Class I by HIV-1 Nef. [PDF]

PLoS ONE, 2015
The HIV-1-encoded protein, Nef, plays a key role in the development of AIDS. One of Nef's functions is to keep MHC class I off the surface of infected cells, a process that requires the host proteins clathrin and AP-1. To identify other proteins involved
Maja K Choma, Jennifer Lumb, Patrycja Kozik, Margaret S Robinson   +3 more
doaj   +1 more source

HIV Nef enhances the expression of oncogenic c-MYC and activation-induced cytidine deaminase in Burkitt lymphoma cells, promoting genomic instability

Infectious Agents and Cancer, 2020
Background Non-Hodgkin lymphoma is of high prevalence among HIV-infected people. In particular, the incidence of HIV-associated Burkitt lymphoma (BL) remains high despite the advent of Highly Active Anti-Retroviral Therapy.
Nontlantla Mdletshe, Andrew Nel, Karen Shires, Shaheen Mowla   +3 more
doaj   +1 more source