Results 31 to 40 of about 12,393 (180)

The Human Immunodeficiency Virus Type 1nefGene Can to a Large Extent Replace Simian Immunodeficiency VirusnefIn Vivo [PDF]

Journal of Virology, 1999
ABSTRACTThenefgene of the pathogenic simian immunodeficiency virus (SIV) 239 clone was replaced with primary human immunodeficiency virus type 1 (HIV-1)nefalleles to investigate whether HIV-1 Nef can substitute for SIV Nef in vivo. Initially, two rhesus macaques were infected with the chimeric viruses (Nef-SHIVs).
Kirchhoff, Frank, Münch, Jan, Carl, Silke, Stolte, Nicole, Mätz-Rensing, Kerstin, Fuchs, Dietmar, Ten Haaft, Peter, Heeney, Jonathan L., Swigut, Tomek, Skowronski, Jacek, Stahl-Hennig, Christiane   +10 more
openaire   +3 more sources

The Effects of Heat Shock Proteins on Delivery of HIV-1 Nef Antigen in Mammalian Cells

Vaccine Research, 2020
Introduction: Vaccine design is mainly considered as a therapeutic strategy to elicit HIV-specific immunity. DNA vaccines encoding an antigen and also an adjuvant can induce an effective adaptive immunity. Due to having numerous roles in viral infection,
Alireza Milani, Fatemeh Rouhollah, Maryam Naseroleslami, Azam Bolhassani   +3 more
doaj  

Evolution of the HIV-1 nef gene in HLA-B*57 Positive Elite Suppressors

Retrovirology, 2010
Elite controllers or suppressors (ES) are HIV-1 infected patients who maintain viral loads of < 50 copies/ml without antiretroviral therapy. CD8+ T cells are thought to play a key role in the control of viral replication and exert selective pressure on ...
Siliciano Robert F, Ray Stuart C, Bailey Justin R, O'Connell Karen A, Brennan Timothy P, Salgado Maria, Blankson Joel N   +6 more
doaj   +1 more source

HIV-1-related factors interact with p53 to influence cellular processes

AIDS Research and Therapy, 2023
Human immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif).
Shanling Liu, Ting Guo, Jinwei Hu, Weiliang Huang, Pengfei She, Yong Wu   +5 more
doaj   +1 more source

Overexpression of recombinant HIV-1 Subtype C Tat and Nef in a Salmonella vaccine vector

The Pan African Medical Journal, 2013
Tat and Nef are very important regulatory proteins of HIV-1. They enhance viral replication and down-regulate expression of MHC Class I molecules, respectively. The antigens are now considered to be targets for HIV vaccine development.
Nyasha Chineombe, Maribanyana Lebeko, Mankgopo Kgatle   +2 more
doaj   +1 more source

Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and HCV co-infection. [PDF]

PLoS ONE, 2018
To elucidate HIV-1 co-infection-induced acceleration of HCV liver disease and identify stage-specific molecular signatures, we applied a new high-resolution molecular screen, the Affymetrix GeneChip Human Transcriptome Array (HTA2.0), to HCV-mono- and ...
Amanda Whitmill, Seongcheol Kim, Vivian Rojas, Fahad Gulraiz, Kazi Afreen, Mamta Jain, Meharvan Singh, In-Woo Park   +7 more
doaj   +1 more source

Expression, purification and biochemical characterisation of the human immunodificiency virus 1 nef gene product [PDF]

European Journal of Biochemistry, 1992
The human immunodeficiency virus 1 (HIV‐1) nef gene encoded by the HIV‐1 isolate lymphadenopathy‐associated virus type 1 was expressed in Escherichia coli under the control of the tac promoter. The protein is found mainly in the soluble part of the bacterial lysate; a simple twocolumn purification scheme has been developed allowing isolation of the ...
Wolber, V., Rensland, H., Brandmeier, B., Sagemann, M., Hoffmann, R., Kalbitzer, H., Wittinghofer, A.   +6 more
openaire   +4 more sources

Characterization of HIV-1 gag and nef in Cameroon: further evidence of extreme diversity at the origin of the HIV-1 group M epidemic

Virology Journal, 2013
Background Cameroon, in west central Africa, has an extraordinary degree of HIV diversity, presenting a major challenge for the development of an effective HIV vaccine. Given the continuing need to closely monitor the emergence of new HIV variants in the
Tongo Marcel, Martin Darren P, Zembe Lycias, Mpoudi-Ngole Eitel, Williamson Carolyn, Burgers Wendy A   +5 more
doaj   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source