Results 31 to 40 of about 1,695,057 (181)

HIV-1-related factors interact with p53 to influence cellular processes

AIDS Research and Therapy, 2023
Human immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif).
Shanling Liu, Ting Guo, Jinwei Hu, Weiliang Huang, Pengfei She, Yong Wu   +5 more
doaj   +1 more source

Nef-containing exosomes deliver Nef to macrophages.

, 2019
A—Size distribution of the extracellular vesicles secreted by HEK293 cells determined by EM; Inset–EM micrograph of the vesicles; bar– 200 nm. B—Western blot for the exosomal marker Alix and Nef in cells and exosomes (exNef); C—Western blot for the ...
Ryunosuke Ohkawa (514009), Andrew Murphy (341397), Hann Low (6612692), Peter J. Meikle (54253), Dmitri Sviridov (54259), Michael Ditiatkovski (432029), Yury I. Miller (181644), Ying Fu (173963), Nigora Mukhamedova (54252), Tatiana Pushkarsky (363651), Michael Bukrinsky (45092), Beda Brichacek (361586), Dragana Dragoljevic (7042715), Larisa Dubrovsky (45091), Anelia Horvath (444445), Anh Hoang (6612695)   +15 more
core   +1 more source

Differential Effects of Human Immunodeficiency Virus Nef Variants on Pulmonary Vascular Endothelial Cell Dysfunction

Infectious Disease Reports
Background: Human Immunodeficiency Virus (HIV) infections remain a source of cardiopulmonary complications among people receiving antiretroviral therapy.
Amanda K. Garcia, Noelia C. Lujea, Javaria Baig, Eli Heath, Minh T. Nguyen, Mario Rodriguez, Preston Campbell, Isabel Castro Piedras, Edu Suarez Martinez, Sharilyn Almodovar   +9 more
doaj   +1 more source

Overexpression of recombinant HIV-1 Subtype C Tat and Nef in a Salmonella vaccine vector

The Pan African Medical Journal, 2013
Tat and Nef are very important regulatory proteins of HIV-1. They enhance viral replication and down-regulate expression of MHC Class I molecules, respectively. The antigens are now considered to be targets for HIV vaccine development.
Nyasha Chineombe, Maribanyana Lebeko, Mankgopo Kgatle   +2 more
doaj   +1 more source

Signature molecules expressed differentially in a liver disease stage-specific manner by HIV-1 and HCV co-infection. [PDF]

PLoS ONE, 2018
To elucidate HIV-1 co-infection-induced acceleration of HCV liver disease and identify stage-specific molecular signatures, we applied a new high-resolution molecular screen, the Affymetrix GeneChip Human Transcriptome Array (HTA2.0), to HCV-mono- and ...
Amanda Whitmill, Seongcheol Kim, Vivian Rojas, Fahad Gulraiz, Kazi Afreen, Mamta Jain, Meharvan Singh, In-Woo Park   +7 more
doaj   +1 more source

Characterization of HIV-1 gag and nef in Cameroon: further evidence of extreme diversity at the origin of the HIV-1 group M epidemic

Virology Journal, 2013
Background Cameroon, in west central Africa, has an extraordinary degree of HIV diversity, presenting a major challenge for the development of an effective HIV vaccine. Given the continuing need to closely monitor the emergence of new HIV variants in the
Tongo Marcel, Martin Darren P, Zembe Lycias, Mpoudi-Ngole Eitel, Williamson Carolyn, Burgers Wendy A   +5 more
doaj   +1 more source

Functional variation in butterfly egg pore traits: The potential role of climate

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Immobile eggs of terrestrial animals are exposed to variable environmental conditions. Insect egg pores, critical for gas exchange (aeropyles) and fertilisation (micropyles), are ecologically important yet understudied.
Teun de Jong, Liana O. Greenberg, Ella Catley, Nina E. Fatouros, Graziella Iossa   +4 more
wiley   +1 more source

Genetic defects in the nef gene are associated with Korean Red Ginseng intake: monitoring of nef sequence polymorphisms over 20 years

Journal of Ginseng Research, 2017
Background: The presence of gross deletions in the human immunodeficiency virus nef gene (gΔnef) is associated with long-term nonprogression of infected patients.
Young-Keol Cho, Jung-Eun Kim, Jun-Hee Woo   +2 more
doaj   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

HIV-1 Nef Disrupts CD4 T Lymphocyte Polarity, Extravasation, and Homing to Lymph Nodes via Its Nef-Associated Kinase Complex Interface. [PDF]

, 2018
HIV-1 Nef is a multifunctional protein that optimizes virus spread and promotes immune evasion of infected cells to accelerate disease progression in AIDS patients.
Thoma, Judith, Reif, Tatjana, Tsopoulidis, Nikolaos, Trautz, Birthe, Cui, Guoliang, Arora, Sakshi, Wu, Jingxia, Kaw, Sheetal, Ambiel, Ina, Imle, Andrea, Lamas-Murua, Miguel, Stolp, Bettina, Tanaka, Motomu, Lyck, Ruth, Fackler, Oliver T, Tibroni, Nadine, Stein, Jens Volker   +16 more
core   +1 more source