Results 31 to 40 of about 13,075 (222)

Effects of HIV-1 nef on cellular gene expression profiles

Journal of Biomedical Science, 2002
The early human immunodeficiency virus (HIV) accessory protein Nef makes an important contribution to virulence, but the mechanisms by which Nef influences pathogenesis remain unclear. Many well-studied effects of Nef, like CD4 and class I MHC downregulation, occur posttranslationally.
Syed, Shaheduzzaman, Vyjayanthi, Krishnan, Ana, Petrovic, Michael, Bittner, Paul, Meltzer, Jeffrey, Trent, Sundararajan, Venkatesan, Steven, Zeichner   +7 more
openaire   +2 more sources

Relative Resistance of HLA-B to Downregulation by Naturally Occurring HIV-1 Nef Sequences

mBio, 2016
HIV-1 Nef binds to the cytoplasmic region of HLA-A and HLA-B and downregulates these molecules from the surface of virus-infected cells, thus evading immune detection by CD8+ T cells.
Macdonald Mahiti, Mako Toyoda, Xiaofei Jia, Xiaomei T. Kuang, Francis Mwimanzi, Philip Mwimanzi, Bruce D. Walker, Yong Xiong, Zabrina L. Brumme, Mark A. Brockman, Takamasa Ueno   +10 more
doaj   +1 more source

Next-generation sequencing analyses of the emergence and maintenance of mutations in CTL epitopes in HIV controllers with differential viremia control

Retrovirology, 2018
Background Despite the low level of viral replication in HIV controllers (HICs), studies have reported viral mutations related to escape from cytotoxic T-lymphocyte (CTL) response in HIV-1 plasma sequences.
Diogo Gama Caetano, Fernanda Heloise Côrtes, Gonzalo Bello, Sylvia Lopes Maia Teixeira, Brenda Hoagland, Beatriz Grinsztejn, Valdilea Gonçalves Veloso, Monick Lindenmeyer Guimarães, Mariza Gonçalves Morgado   +8 more
doaj   +1 more source

Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins

Cell Reports, 2015
NF-κB is essential for effective transcription of primate lentiviral genomes and also activates antiviral host genes. Here, we show that the early protein Nef of most primate lentiviruses enhances NF-κB activation.
Daniel Sauter, Dominik Hotter, Benoît Van Driessche, Christina M. Stürzel, Silvia F. Kluge, Steffen Wildum, Hangxing Yu, Bernd Baumann, Thomas Wirth, Jean-Christophe Plantier, Marie Leoz, Beatrice H. Hahn, Carine Van Lint, Frank Kirchhoff   +13 more
doaj   +1 more source

Nef-induced differential gene expression in primary CD4+ T cells following infection with HIV-1 isolates [PDF]

, 2019
Almost 80% of viral transcripts during early HIV-1 infection encode the Nef protein, which has been implicated in altering expression of a number of genes.
Yang, Otto O, Ali, Ayub, Nixon, Douglas F, Furler, Robert L   +3 more
core   +1 more source

Polymorphism of the Human Immunodeficiency Virus Type 1 in Brazil: Genetic Characterization of the nef Gene and Implications for Vaccine Design

Memorias do Instituto Oswaldo Cruz, 2002
Most of the Brazilian HIV-1 samples have been characterized based on the structural genes (env, gag and pol) and no data concerning the variability of the accessory genes such as nef have been available so far.
ML Guimarães, AS Moreira, MG Morgado
doaj   +1 more source

Nef gene evolution from a single transmitted strain in acute SIV infection [PDF]

Retrovirology, 2009
Abstract Background The acute phase of immunodeficiency virus infection plays a crucial role in determining steady-state virus load and subsequent progression of disease in both humans and nonhuman primates. The acute period is also the time when vaccine-mediated effects on host immunity are likely to exert their ...
Bimber, BN, Chugh, P, Giorgi, EE, Kim, B, Almudevar, AL, Dewhurst, S, O'Connor, DH, Lee, HY   +7 more
openaire   +3 more sources

The Human Immunodeficiency Virus Type 1nefGene Can to a Large Extent Replace Simian Immunodeficiency VirusnefIn Vivo [PDF]

Journal of Virology, 1999
ABSTRACTThenefgene of the pathogenic simian immunodeficiency virus (SIV) 239 clone was replaced with primary human immunodeficiency virus type 1 (HIV-1)nefalleles to investigate whether HIV-1 Nef can substitute for SIV Nef in vivo. Initially, two rhesus macaques were infected with the chimeric viruses (Nef-SHIVs).
Kirchhoff, Frank, Münch, Jan, Carl, Silke, Stolte, Nicole, Mätz-Rensing, Kerstin, Fuchs, Dietmar, Ten Haaft, Peter, Heeney, Jonathan L., Swigut, Tomek, Skowronski, Jacek, Stahl-Hennig, Christiane   +10 more
openaire   +3 more sources

Tracking the Emergence of Host-Specific Simian Immunodeficiency Virus env and nef Populations Reveals nef Early Adaptation and Convergent Evolution in Brain of Naturally Progressing Rhesus Macaques [PDF]

, 2015
UnlabelledWhile a clear understanding of the events leading to successful establishment of host-specific viral populations and productive infection in the central nervous system (CNS) has not yet been reached, the simian immunodeficiency virus (SIV ...
Goodenow, Maureen M, Nolan, David J, Salemi, Marco, McGrath, Michael S, Autissier, Patrick, Williams, Kenneth C, Fogel, Gary B, Lamers, Susanna L, Rife, Brittany D, Burdo, Tricia H   +9 more
core   +1 more source

The Effects of Heat Shock Proteins on Delivery of HIV-1 Nef Antigen in Mammalian Cells

Vaccine Research, 2020
Introduction: Vaccine design is mainly considered as a therapeutic strategy to elicit HIV-specific immunity. DNA vaccines encoding an antigen and also an adjuvant can induce an effective adaptive immunity. Due to having numerous roles in viral infection,
Alireza Milani, Fatemeh Rouhollah, Maryam Naseroleslami, Azam Bolhassani   +3 more
doaj