Results 41 to 50 of about 12,393 (180)
Journal of Neuroinflammation, 2018 Background HIV-associated neurocognitive disorder (HAND) is a neurodegenerative disease associated with persistent neuroinflammation and subsequent neuron damage.
Feng Zhou +16 more
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Pathogens, 2022 HIV-1 infection of myeloid cells is associated with the induction of an IFN response. How HIV-1 manipulates and subverts the IFN response is of key interest for the design of therapeutics to improve immune function and mitigate immune dysregulation in ...
Laura J. Martins +5 more
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The FEBS Journal, EarlyView.Evolutionary and mechanistic divergence in the Hsp70–Hsp110 chaperone system. Prokaryotic Hsp70s probably diversified into multiple orthologues that cooperated with co‐chaperones such as JDPs and NEF, forming increasingly complex proteostasis networks.
Pierre Goloubinoff +2 more
wiley +1 more source
Safety and immunogenicity of DNA and MVA HIV-1 subtype C vaccine prime-boost regimens: a phase I randomised Trial in HIV-uninfected Indian volunteers. [PDF]
PLoS ONE, 2013 STUDY DESIGN: A randomized, double-blind, placebo controlled phase I trial. METHODS: The trial was conducted in 32 HIV-uninfected healthy volunteers to assess the safety and immunogenicity of prime-boost vaccination regimens with either 2 doses of ADVAX,
Sanjay Mehendale +20 more
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Expression and biochemical characterization of human immunodeficiency virus type 1 nef gene product [PDF]
Journal of Virology, 1990 nef genes from human immunodeficiency virus type 1 isolates BH10 and LAV1 (lymphadenopathy-associated virus type 1) were expressed in Escherichia coli under the deo operon promoter. The two proteins found in the soluble compartment of the bacterial lysate were purified by ion-exchange column chromatography to apparent homogeneity.
J, Kaminchik +9 more
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Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle
The FEBS Journal, EarlyView.EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini +4 more
wiley +1 more source
The Vpr protein from HIV-1: distinct roles along the viral life cycle
Retrovirology, 2005 The genomes of human and simian immunodeficiency viruses (HIV and SIV) encode the gag, pol and env genes and contain at least six supplementary open reading frames termed tat, rev, nef, vif, vpr, vpx and vpu. While the tat and rev genes encode regulatory
Benichou Serge, Le Rouzic Erwann
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Viruses, 2021 We aimed to investigate whether the sequence length of HIV-1 increases over time. We performed a longitudinal analysis of full-length coding region sequences (FLs) during an HIV-1 outbreak among patients with hemophilia and local controls infected with ...
Young-Keol Cho +2 more
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Journal of Fish Biology, EarlyView.Abstract Marine fish species are likely to exhibit little genetic differentiation among populations due to their high dispersal potential during early life stages and migratory nature. However, recent studies have increasingly reported intraspecific genetic differentiation resulting from species‐specific ecological traits, environmental factors, and ...
Yuki Yamamoto +7 more
wiley +1 more source
Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo [PDF]
Journal of Virology, 1993 The nef genes of the human immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) and the related simian immunodeficiency viruses (SIVs) encode a protein (Nef) whose role in virus replication and cytopathicity remains uncertain. As an attempt to elucidate the function of nef, we characterized the nucleotide and corresponding protein sequences of ...
D C, Shugars +5 more
openaire +2 more sources