Results 51 to 60 of about 13,075 (222)

Nef enhances HIV-1 replication and infectivity independently of SERINC5 in CEM T cells [PDF]

, 2023
A primary function of HIV-1 Nef is the enhancement of viral infectivity and replication. Whether counteraction of the antiretroviral proteins SERINC3 and SERINC5 is the cause of this positive influence on viral growth-rate and infectivity remains unclear.
Guatelli, John, Ramirez, Peter W, Acosta, Francisco M, Angerstein, Aaron O, Vollbrecht, Thomas, Suarez, Marissa, Wallace, Jared, Connell, Ryan M O’   +7 more
core   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

HIV-1 Nef-induced lncRNA AK006025 regulates CXCL9/10/11 cluster gene expression in astrocytes through interaction with CBP/P300

Journal of Neuroinflammation, 2018
Background HIV-associated neurocognitive disorder (HAND) is a neurodegenerative disease associated with persistent neuroinflammation and subsequent neuron damage.
Feng Zhou, Xiaomei Liu, Dongjiao Zuo, Min Xue, Lin Gao, Ying Yang, Jing Wang, Liping Niu, Qianwen Cao, Xiangyang Li, Hui Hua, Bo Zhang, Minmin Hu, Dianshuai Gao, Kuiyang Zheng, Yoshihiro Izumiya, Renxian Tang   +16 more
doaj   +1 more source

HIV-1 Accessory Proteins Impart a Modest Interferon Response and Upregulate Cell Cycle-Related Genes in Macrophages

Pathogens, 2022
HIV-1 infection of myeloid cells is associated with the induction of an IFN response. How HIV-1 manipulates and subverts the IFN response is of key interest for the design of therapeutics to improve immune function and mitigate immune dysregulation in ...
Laura J. Martins, Matthew A. Szaniawski, Elizabeth S. C. P. Williams, Mayte Coiras, Timothy M. Hanley, Vicente Planelles   +5 more
doaj   +1 more source

The role of iron in normal and impaired testicular function

Andrology, EarlyView.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Expression and biochemical characterization of human immunodeficiency virus type 1 nef gene product [PDF]

Journal of Virology, 1990
nef genes from human immunodeficiency virus type 1 isolates BH10 and LAV1 (lymphadenopathy-associated virus type 1) were expressed in Escherichia coli under the deo operon promoter. The two proteins found in the soluble compartment of the bacterial lysate were purified by ion-exchange column chromatography to apparent homogeneity.
J, Kaminchik, N, Bashan, D, Pinchasi, B, Amit, N, Sarver, M I, Johnston, M, Fischer, Z, Yavin, M, Gorecki, A, Panet   +9 more
openaire   +2 more sources

Role of Nef in primate lentiviral immunopathogenesis

, 2008
International audienceMore than a decade ago it was established that intact nef genes are critical for efficient viral persistence and greatly accelerate disease progression in SIVmac-infected rhesus macaques and in HIV-1-infected humans.
Münch, J., Kirchhoff, F., Specht, A., Arhel, N., Schindler, M.   +4 more
core   +1 more source

Safety and immunogenicity of DNA and MVA HIV-1 subtype C vaccine prime-boost regimens: a phase I randomised Trial in HIV-uninfected Indian volunteers. [PDF]

PLoS ONE, 2013
STUDY DESIGN: A randomized, double-blind, placebo controlled phase I trial. METHODS: The trial was conducted in 32 HIV-uninfected healthy volunteers to assess the safety and immunogenicity of prime-boost vaccination regimens with either 2 doses of ADVAX,
Sanjay Mehendale, Madhuri Thakar, Seema Sahay, Makesh Kumar, Ashwini Shete, Pattabiraman Sathyamurthi, Amita Verma, Swarali Kurle, Aparna Shrotri, Jill Gilmour, Rajat Goyal, Len Dally, Eddy Sayeed, Devika Zachariah, James Ackland, Sonali Kochhar, Josephine H Cox, Jean-Louis Excler, Vasanthapuram Kumaraswami, Ramesh Paranjape, Vadakkuppatu Devasenapathi Ramanathan   +20 more
doaj   +1 more source

The R203W substitution drives PACS‐1 syndrome by disrupting intramolecular regulation

The FEBS Journal, EarlyView.
The middle region (MR) of PACS‐1 controls engagement with specific partner proteins. This manuscript presents the structure of the Furin binding region (FBR) and how interactions with partners are regulated through the interplay between a basic patch in the FBR and an acidic cluster in the MR.
Troy C. Krzysiak, In‐Ja L. Byeon, Ryan Ponticelli, Mary E. Lucas, Lariah Thompson, Christopher DeHaven, Gary Thomas, Angela M. Gronenborn   +7 more
wiley   +1 more source

The Vpr protein from HIV-1: distinct roles along the viral life cycle

Retrovirology, 2005
The genomes of human and simian immunodeficiency viruses (HIV and SIV) encode the gag, pol and env genes and contain at least six supplementary open reading frames termed tat, rev, nef, vif, vpr, vpx and vpu. While the tat and rev genes encode regulatory
Benichou Serge, Le Rouzic Erwann
doaj   +1 more source