Results 71 to 80 of about 12,393 (180)
Viral factors in non-progression
Frontiers in Immunology, 2013 Research has undergone considerable development in understanding a small subset of human immunodeficiency virus type 1 (HIV-1)-infected, therapy-naive individuals who maintain a favourable course of infection surviving for longer periods of time ...
Bin eWang
doaj +1 more source
Bio-Protocol, 2017 The current study provides detailed protocols utilized to amplify the complete HIV-1 gp120 and nef genes from single copies of expressed or integrated HIV present in fresh-frozen autopsy tissues of patients who died while on combined antiretroviral ...
David Nolan +5 more
doaj +1 more source
Inhibition of Protein Synthesis by the Human Immunodeficiency Virus Type 1 nef Gene Product
Journal of General Virology, 1994 During productive infection of human T lymphocytes in cell culture, the expression of human immunodeficiency virus type 1 is temporally regulated by virus-encoded regulatory proteins. Among these Nef, whose function has not been clearly elucidated, is thought to alter CD4+ T cells.
L, Poulin +3 more
openaire +2 more sources
American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1362-1371, June 2026.ABSTRACT To investigate the correlation between genetic abnormalities and fetal genitourinary (GU) anomalies in Eastern China and to provide assistance for the clinical management of fetuses with different types of GU anomalies. Five hundred forty‐five fetuses with GU anomalies were enrolled, undergoing karyotyping, copy number variation sequencing ...
Jie Liang +6 more
wiley +1 more source
Frontiers in Microbiology, 2020 The genetic evolution of HIV-1 from its progenitor virus SIV following cross-species transmission is not well understood. Here we simulated the SIVcpz initial transmission to humans using humanized mice and followed the viral evolution during serial ...
Kimberly Schmitt +9 more
doaj +1 more source
Natural variation of the nef gene in human immunodeficiency virus type 2 infections in Portugal
Journal of General Virology, 2003 Human immunodeficiency virus type 2 (HIV-2) infections cause severe immunodeficiency in humans, although HIV-2 is associated frequently with reduced virulence and pathogenicity compared to HIV-1. Genetic determinants that play a role in HIV pathogenesis are relatively poorly understood but nef has been implicated in inducing a more pathogenic phenotype
Elizabeth, Padua +6 more
openaire +2 more sources
Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5
MedComm, Volume 7, Issue 6, June 2026.The seasonal human coronaviruses 229E and OC43 are common causes of mild respiratory infections but can cause severe disease in vulnerable individuals. Serine incorporator 5 (SERINC5) efficiently inhibits OC43, while hCoV‐229E uses its ORF4/4a accessory proteins to efficiently counteract this restriction by promoting relocalization of SERINC5 to ...
Qinya Xie +9 more
wiley +1 more source
PLoS ONE, 2011 A very small proportion of people remain negative for HIV infection after repeated HIV-1 viral exposure, which is called HIV-1 resistance. Understanding the mechanism of HIV-1 resistance is important for the development of HIV-1 vaccines and Acquired ...
Tao Huang +4 more
doaj +1 more source
Simian immunodeficiency virus Nef gene regulates the production of 2-LTR circles in vivo
Virology, 2003 The replication dynamics of simian immunodeficiency virus (SIVmac32H-C8), attenuated through discrete genetic disruption of the nef gene, were compared with the wild-type parental clone (SIVmac32H-J5) using quantitative molecular methods. The primary viraemia of both infections were similar during the first week, but peaked on Day 10 at higher levels ...
Clarke, S, Almond, N, Berry, N
openaire +2 more sources
Characterization of transgene expression in adenoviral vector-based HIV-1 vaccine candidates
Virology Journal, 2010 Recombinant adenovirus vectors have been extensively used in gene therapy clinical studies. More recently, the capability of inducing potent cell-mediated and humoral immunity has made these vectors equally attractive candidates for prophylactic or ...
Rolling Judith A +2 more
doaj +1 more source