Results 71 to 80 of about 1,695,057 (181)

Rapidly evolving genes and stress adaptation of two desert poplars, Populus euphratica and P. pruinosa [PDF]

open access: yes, 2013
Understanding which genes have evolved rapidly with the recent tree speciation in arid habitats can provide valuable insights into different adaptation mechanisms. We employed a comparative evolutionary analysis of expressed sequence tags (ESTs) from two
Penghui Xie (420345)   +21 more
core   +1 more source

varioustoxins/NEF-Pipelines: 0.1.65

open access: yes
<h1>NEF-Pipelines</h1> <p>A set of command line (currently... there maybe a gui later!) tools for maniulating [NEF] or NMR Exchange Format files which can be used to move NMR meta data [peaks, shifts, sequences etc] between NMR data ...
varioustoxins, locsmith, gweatherby
core   +1 more source

Host restriction factors in retroviral infection: promises in virus-host interaction

open access: yesRetrovirology, 2012
Retroviruses have an intricate life cycle. There is much to be learned from studying retrovirus-host interactions. Among retroviruses, the primate lentiviruses have one of the more complex genome structures with three categories of viral genes ...
Zheng Yong-Hui   +2 more
doaj   +1 more source

Targeting Human Immunodeficiency Virus Integrase Beyond the Active Site: The Discovery and Development of Allosteric Integrase Inhibitors

open access: yesChemMedChem, Volume 21, Issue 16, 27 August 2026.
Human immunodeficiency virus (HIV) allosteric integrase inhibitors (ALLINIs) offer a vital alternative to standard therapies by targeting noncatalytic sites. By inducing aberrant integrase multimerization, they disrupt viral maturation. This review explores their medicinal chemistry evolution, detailing structural insights, structure–activity ...
Francesco Saccoliti   +10 more
wiley   +1 more source

Nef-isocyanide-Perkow access to novel pyrazolone derivations containing a cyclic ketene dithioacetal moiety

open access: yes, 2019
Alkyl (E)-2-(3-Alkyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)-5-(alkylamino)-1,3-dithiole-4-carboxylates have been obtained by condensation of 2-pyrazolin-5-ones with carbon disulfide followed by ring formation with phosphorylated ...
Issa Yavari (657967)   +3 more
core   +1 more source

Viral factors in non-progression

open access: yesFrontiers in Immunology, 2013
Research has undergone considerable development in understanding a small subset of human immunodeficiency virus type 1 (HIV-1)-infected, therapy-naive individuals who maintain a favourable course of infection surviving for longer periods of time ...
Bin eWang
doaj   +1 more source

Endochitinase Overexpression in Transgenic Tomato Plants Improves Resistance to Phytopathogens

open access: yesBiotechnology Journal, Volume 21, Issue 8, August 2026.
Graphical Abstract and Lay Summary Transgenic tomato plants overexpressing an endochitinase gene showed confirmed transgene expression and enhanced resistance. Upon plants inoculations with Xanthomonas euvesicatoria pv. perforans and Sclerotinia sclerotiorum, disease severity was significantly reduced compared to wild‐type plants, demonstrating broad ...
Lucas José de Sousa   +10 more
wiley   +1 more source

Single Genome Sequencing of Expressed and Proviral HIV-1 Envelope Glycoprotein 120 (gp120) and nef Genes

open access: yesBio-Protocol, 2017
The current study provides detailed protocols utilized to amplify the complete HIV-1 gp120 and nef genes from single copies of expressed or integrated HIV present in fresh-frozen autopsy tissues of patients who died while on combined antiretroviral ...
David Nolan   +5 more
doaj   +1 more source

Single‐Nucleus Multiomic Analysis Reveals Immune–Metabolic Reprogramming Consistent With Maladaptive Trained Immunity in HIV‐Associated Neurocognitive Disorders

open access: yesGlia, Volume 74, Issue 8, August 2026.
Single‐nucleus multiomic profiling of postmortem brain reveals coordinated immune, metabolic, and epigenomic reprogramming in glia of people with HIV consistent with maladaptive trained immunity sustaining neuroinflammation in HAND. ABSTRACT HIV‐associated neurocognitive disorders (HAND) remain prevalent in people with HIV (PWH) despite effective ...
Siera Martinez   +8 more
wiley   +1 more source

Contrasting population genetic structures of congeneric coastal flounders associated with different early life histories

open access: yesJournal of Fish Biology, Volume 109, Issue 2, Page 1141-1159, August 2026.
Abstract Marine fish species are likely to exhibit little genetic differentiation among populations due to their high dispersal potential during early life stages and migratory nature. However, recent studies have increasingly reported intraspecific genetic differentiation resulting from species‐specific ecological traits, environmental factors, and ...
Yuki Yamamoto   +7 more
wiley   +1 more source

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