Results 71 to 80 of about 13,075 (222)

Phylogenetic Analysis of the Earliest nef Gene from Hemophiliacs and Local Controls in Korea

BioResearch Open Access, 2012
Twenty hemophiliacs (HPs) were found to have human immunodeficiency virus type-1 (HIV-1) 1-2 years after exposure to Factor IX manufactured in Korea in late 1989. Plasma samples collected from donors O and P during their pre-seroconversion acute infection stage were used to manufacture clotting factors, including Factor IX, to treat these patients.
Cho, Young-Keol, Kim, Jung-Eun, Foley, Brian T.   +2 more
openaire   +2 more sources

HIV-1 nef leads to inhibition or activation of T cells depending on its intracellular localization

, 1994
Nef of primate lentiviruses is required for viremia and progression to AIDS in monkeys. Negative, positive, and no effects of Nef have also been reported on viral replication in cells.
Baur, A. S., B. Matija Peterlin, Sawai, E. T., Wendy J. Fantl, Dazin, P., Andreas S. Baur, Earl T. Sawai, Paul Dazin, Cecilia Cheng-Mayer, Peterlin, B. M., Fantl, W. J., Cheng-Mayer, C.   +11 more
core   +1 more source

Deletion, insertion and stop codon mutations in vif genes of HIV-1 infecting slow progressor patients

Journal of Infection in Developing Countries, 2009
Background: Variable progression towards AIDS has been described and has been related to viral and host factors. Around 10% of the HIV-1 infected patients are slow progressors (SP), not presenting with AIDS disease signs even after more than 10 years of ...
Héctor Rafael Rangel, Domingo Garzaro, Anny Karely Rodríguez, Alvaro Hernán Ramírez, Gladys Ameli, Cristina del Rosario Gutiérrez, Flor Helene Pujol   +6 more
doaj   +1 more source

Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells

, 2005
Several recent reports indicate that cholesterol might play an important role in human immunodeficiency virus type 1 (HIV-1) replication. We investigated the effects of HIV-1 infection on cholesterol biosynthesis and uptake using microarrays.
Kirchhoff, Frank, Swain, J. Victor, Schindler, Michael, Mullins, James I., Rao, Ushnal, Pathmajeyan, Melissa S., van 't Wout, Angélique B.   +6 more
core   +1 more source

Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation.

PLoS Pathogens, 2017
Primate lentiviruses have evolved sophisticated strategies to suppress the immune response of their host species. For example, HIV-2 and most simian immunodeficiency viruses (SIVs) use their accessory protein Nef to prevent T cell activation and ...
Dominik Hotter, Teresa Krabbe, Elisabeth Reith, Ali Gawanbacht, Nadia Rahm, Ahidjo Ayouba, Benoît Van Driessche, Carine Van Lint, Martine Peeters, Frank Kirchhoff, Daniel Sauter   +10 more
doaj   +1 more source

Genetic Abnormalities and Clinical Management of Fetal Genitourinary System Anomalies in Eastern China

American Journal of Medical Genetics Part A, Volume 200, Issue 6, Page 1362-1371, June 2026.
ABSTRACT To investigate the correlation between genetic abnormalities and fetal genitourinary (GU) anomalies in Eastern China and to provide assistance for the clinical management of fetuses with different types of GU anomalies. Five hundred forty‐five fetuses with GU anomalies were enrolled, undergoing karyotyping, copy number variation sequencing ...
Jie Liang, Jiebin Wu, Lin Zhang, Yunmeng Qi, Yi Wang, Xu Cao, Jingfang Zhai   +6 more
wiley   +1 more source

Evidence for Adaptive Evolution at the Divergence Between Lymphoid and Brain HIV-1 nef Genes [PDF]

AIDS Research and Human Retroviruses, 2010
Human immunodeficiency virus type 1 (HIV) infection of the central nervous system frequently causes HIV-associated neurocognitive disorders (HAND). The role of HIV Nef and other accessory proteins in HAND pathogenesis is unclear. To determine whether HIV nef undergoes adaptive selection in ...
Kevin C, Olivieri, Kristin A, Agopian, Joya, Mukerji, Dana, Gabuzda   +3 more
openaire   +2 more sources

Y86 is critical for SERINC3/5 antagonism by SIVcol Nef.

, 2018
(A) Alignment of the amino acid sequences of HIV and SIV Nef proteins. Dots indicate gaps. Functional amino acid motifs are highlighted. Y residues in SIVcol Nef that were mutated for functional analyses are indicated in green.
Christina M. Stürzel (3752773), Frank Kirchhoff (94157), Igor Stagljar (42523), Vânia Passos (5646386), Oliver T. Fackler (36453), Daniel Sauter (109619), Dorota Kmiec (5646374), Zhong Yao (361911), Thomas Zillinger (408718), Birthe Trautz (5646383), Dominik Hotter (4405666), Konstantin M. J. Sparrer (553762), Christine Goffinet (90029), Bengisu Akbil (5646377), Swetha Ananth (5646380), Ahidjo Ayouba (256440), Martine Peeters (50360)   +16 more
core   +1 more source

Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus

Retrovirology, 2007
Background The Sydney blood bank cohort (SBBC) of long-term survivors consists of multiple individuals infected with nef-deleted, attenuated strains of human immunodeficiency virus type 1 (HIV-1).
Wesselingh Steven L, Chiavaroli Lisa, Churchill Melissa J, Gorry Paul R   +3 more
doaj   +1 more source

Human Coronavirus 229E Uses ORF4/4a to Antagonize the Host Restriction Factor SERINC5

MedComm, Volume 7, Issue 6, June 2026.
The seasonal human coronaviruses 229E and OC43 are common causes of mild respiratory infections but can cause severe disease in vulnerable individuals. Serine incorporator 5 (SERINC5) efficiently inhibits OC43, while hCoV‐229E uses its ORF4/4a accessory proteins to efficiently counteract this restriction by promoting relocalization of SERINC5 to ...
Qinya Xie, Sabrina Noettger, Jan Lawrenz, Sophie Stopper, Susanne Klute, Jan Münch, Dorota Kmiec, Qingxing Wang, Konstantin M. J. Sparrer, Frank Kirchhoff   +9 more
wiley   +1 more source