Results 81 to 90 of about 12,393 (180)

Pathogenicity and immunogenicity of attenuated, nef-deleted HIV-1 strains in vivo

Retrovirology, 2007
In efforts to develop an effective vaccine, sterilizing immunity to primate lentiviruses has only been achieved by the use of live attenuated viruses carrying major deletions in nef and other accessory genes.
Wesselingh Steven L, Dyer Wayne B, Verity Erin, McPhee Dale A, Gorry Paul R, Learmont Jennifer, Sullivan John S, Roche Michael, Zaunders John J, Gabuzda Dana, Crowe Suzanne M, Mills John, Lewin Sharon R, Brew Bruce J, Cunningham Anthony L, Churchill Melissa J   +15 more
doaj   +1 more source

Functional association between the nef gene product and gag‐pol region of HIV‐1

FEBS Letters, 2000
Nef gene function is diverse among virus isolates of primate immunodeficiency viruses. We found differential effects of nef mutation on the virus replication between two HIV‐1 clones, NL432 and LAI. The nef mutation in NL432 affected the infectivity more severely compared with that in LAI, although the Nef functions of both clones were comparable ...
Ono, Takeshi, Iwatani, Yasumasa, Nishimura, Akiko, Ishimoto, Akinori, Sakai, Hiroyuki   +4 more
openaire   +2 more sources

A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses.

PLoS ONE, 2011
The vaccinia virus (VACV) C6 protein has sequence similarities with the poxvirus family Pox_A46, involved in regulation of host immune responses, but its role is unknown.
Juan García-Arriaza, José Luis Nájera, Carmen E Gómez, Nolawit Tewabe, Carlos Oscar S Sorzano, Thierry Calandra, Thierry Roger, Mariano Esteban   +7 more
doaj   +1 more source

Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef

Nature Communications
Innate antiviral factors are essential for effective defense against viral pathogens. However, the identity of major restriction mechanisms remains elusive.
Caterina Prelli Bozzo, Alexandre Laliberté, Aurora De Luna, Chiara Pastorio, Kerstin Regensburger, Stefan Krebs, Alexander Graf, Helmut Blum, Meta Volcic, Konstantin M. J. Sparrer, Frank Kirchhoff   +10 more
doaj   +1 more source

Phylogenetic Analysis of the nef Gene Reveals a Distinctive Monophyletic Clade in Korean HIV-1 Cases

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 1998
To study the genetic variation of the HIV-1 strains prevalent in South Korea, we analyzed the nef sequences derived from 46 HIV-1-positive individuals living in various geographic regions in Korea. Phylogenetic analysis revealed four subtypes of HIV-1: A (3 patients), B (41 patients), D (1 patient), and a type that could not be clearly classified to ...
M R, Kang, Y K, Cho, J, Chun, Y B, Kim, I, Lee, H J, Lee, S H, Kim, Y K, Kim, K, Yoon, J M, Yang, J M, Kim, Y O, Shin, C, Kang, J S, Lee, K W, Choi, D G, Kim, W M, Fitch, S, Kim   +17 more
openaire   +3 more sources

A study of the HIV-1 regulatory genes using the polymerase chain reaction

Вопросы вирусологии, 2015
In this work, a total of 200 samples from the HIV-infected individuals were analyzed: 50 samples from the Saha Republic (Yakutia), 50 samples from the Vologda Region (City of Cherepovets), and 100 samples from the Moscow Region (Moscow and Moscow Region).
K. A. Ryzhov, M. N. Nosik, A. V. Kravtchenko   +2 more
doaj  

Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors.

PLoS ONE, 2011
Attenuated poxviruses are safe and capable of expressing foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans.
Esther D Quakkelaar, Anke Redeker, Elias K Haddad, Alexandre Harari, Stella Mayo McCaughey, Thomas Duhen, Abdelali Filali-Mouhim, Jean-Philippe Goulet, Nikki M Loof, Ferry Ossendorp, Beatriz Perdiguero, Paul Heinen, Carmen E Gomez, Karen V Kibler, David M Koelle, Rafick P Sékaly, Federica Sallusto, Antonio Lanzavecchia, Giuseppe Pantaleo, Mariano Esteban, Jim Tartaglia, Bertram L Jacobs, Cornelis J M Melief   +22 more
doaj   +1 more source

nef gene sequence variation among HIV‐1‐infected African children^*

HIV Medicine, 2006
BackgroundThere are few data on African children infected with nonclade B HIV‐1 in endemic settings, which limits generalizations about pathogenesis and progression. Genotypic and phenotypic variations in host immunogenetics and HIV‐1 negative factor (nef) accessory protein may influence disease progression and have frequently been characterized in ...
Chakraborty, R, Reinis, M, Rostron, T, Philpott, S, Dong, T, D'Agostino, A, Musoke, R, Silva, E, Stumpf, M, Weiser, B, Burger, H, Rowland-Jones, S   +11 more
openaire   +3 more sources

[The expression of a fragment of the HIV-1 Nef gene in Escherichia coli bacteria].

Voprosy virusologii, 1991
The presence of antibodies to p27, the product of gene Nef, may be an important diagnostic sign since some sera from subjects of the risk groups negative to HIV-1 structural proteins may contain antibody to p27. The study resulted in construction of a hybrid plasmid determining in E coli bacteria the synthesis of a hybrid protein the N-terminus part of
M M, Garaev, A F, Bobkov, M Kh, Taĭ, E V, Kazennova   +3 more
openaire   +1 more source

Abstracts From AIDS 2026, the 26th International AIDS Conference, 26 – 31 July 2026 Rio de Janeiro, Brazil & virtual

Journal of the International AIDS Society, Volume 29, Issue S4, July 2026.
wiley   +1 more source