Results 81 to 90 of about 13,075 (222)

Modulation in the Gene Expression Profile of Astrocytes and Monocytes by HIV-1 Nef Variants

, 2022
HIV-1 Nef is a multifunctional protein with well-known lethal properties. HIV infects various cells from the brain compartment and expressed nef is responsible for developing neuropathogenic potential. HIV-infected glial cells express nefvirotoxinand stimulate the cascade of various pathways to activate uninfected cells to release neurotoxic elements ...
Sushama Jadhav, Prajakta Makar, Vijay Nema   +2 more
openaire   +2 more sources

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene [PDF]

Journal of Virology, 1994
The replication competence of human immunodeficiency virus type 1 genomes containing mutations in the nef open reading frame was evaluated in continuous cell lines. Mutants that contained a deletion in the nef open reading frame, premature termination codons, or missense mutations in the N-terminal myristoylation signal were constructed.
M Y, Chowers, C A, Spina, T J, Kwoh, N J, Fitch, D D, Richman, J C, Guatelli   +5 more
openaire   +2 more sources

Heterologous HIV-nef mRNA trans-splicing: a new principle how mammalian cells generate hybrid mRNA and protein molecules

, 2001
Heterologous trans-splicing is a messenger RNA (mRNA) processing mechanism, that joins RNA segments from separate transcripts to generate functional mRNA molecules. We present here for the first time experimental evidence that the proximal segment of the
B. Berg, Graessmann, A., Berg, B., Guhl, E., L. Da Silva-Azevedo, E. Guhl, Caudevilla, C., A. Graessmann, Da Silva-Azevedo, L., Graessmann, M., M. Graessmann, C. Caudevilla   +11 more
core   +1 more source

The ALS‐associated E425K mutation uncouples DNAJC7 from the Hsp70 chaperone cycle

The FEBS Journal, Volume 293, Issue 12, Page 3485-3501, June 2026.
DNAJC7 is a J‐domain protein that plays a key role in protein quality control by regulating Hsp70 activity and preventing protein aggregation. We find that the ALS‐associated E425K mutation in DNAJC7 disrupts productive interaction and activation of Hsp70, thereby blocking the transfer and refolding of client proteins such as TDP‐43.
Bar Elmaleh, Ofrah Faust, Rina Rosenzweig   +2 more
wiley   +1 more source

Host restriction factors in retroviral infection: promises in virus-host interaction

Retrovirology, 2012
Retroviruses have an intricate life cycle. There is much to be learned from studying retrovirus-host interactions. Among retroviruses, the primate lentiviruses have one of the more complex genome structures with three categories of viral genes ...
Zheng Yong-Hui, Jeang Kuan-Teh, Tokunaga Kenzo   +2 more
doaj   +1 more source

The impact of accumulating immune adaptation in circulating strains of HIV‐1

HIV Medicine, Volume 27, Issue 6, Page 918-934, June 2026.
Abstract Background Mutations in human immunodeficiency virus type 1 (HIV‐1) enable the virus to evade recognition and killing by human leucocyte antigen (HLA)‐restricted T cells. These viral adaptations are specific to the HLA type of individuals and are therefore evident as HLA allele‐HIV sequence associations at the population level. Most studies of
Marwah Al‐kaabi, Alison Castley, Pooja Deshpande, Abha Chopra, David Nolan, Simon Mallal, Mina John, Silvana Gaudieri   +7 more
wiley   +1 more source

Exogenous Nef Induces Proinflammatory Signaling Events in Murine Macrophages

, 2012
Despite the fact that murine cells are not permissive for human immunodeficiency virus type 1 (HIV-1) infection, several investigators have constructed transgenic (Tg) mice to model HIV-1-induced diseases to overcome this restriction. The generation of
Borghi, Paola, Florian A. Horenkamp, Borghi, P., Geyer, Matthias, PERCARIO, ZULEMA ANTONIA, Valeria Serra, Zulema A. Percario, Serra, Valeria, A. Horenkamp Florian, Mangino, G., Geyer, M., Horenkamp, Florian A., Affabris, E., Elisabetta Affabris, Mangino, Giorgio, Percario, Zulema A., Geyer Matthias, Percario, Z., Matthias Geyer, Serra, V., Horenkamp, F., Paola Borghi, Affabris, Elisabetta   +22 more
core   +1 more source

Viral factors in non-progression

Frontiers in Immunology, 2013
Research has undergone considerable development in understanding a small subset of human immunodeficiency virus type 1 (HIV-1)-infected, therapy-naive individuals who maintain a favourable course of infection surviving for longer periods of time ...
Bin eWang
doaj   +1 more source

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, Volume 4, Issue 3, May 2026.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Inhibition of Protein Synthesis by the Human Immunodeficiency Virus Type 1 nef Gene Product

Journal of General Virology, 1994
During productive infection of human T lymphocytes in cell culture, the expression of human immunodeficiency virus type 1 is temporally regulated by virus-encoded regulatory proteins. Among these Nef, whose function has not been clearly elucidated, is thought to alter CD4+ T cells.
L, Poulin, M, Fauchon, A, Darveau, J A, Levy   +3 more
openaire   +2 more sources