Results 101 to 110 of about 13,075 (222)
PLoS ONE, 2011 A very small proportion of people remain negative for HIV infection after repeated HIV-1 viral exposure, which is called HIV-1 resistance. Understanding the mechanism of HIV-1 resistance is important for the development of HIV-1 vaccines and Acquired ...
Tao Huang +4 more
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Schematic of the Y2H screen and coimmunoprecipitation of selected preys show interaction with Nef.
, 2012 A. Schematic presentation of the split-ubiquitin Y2H screen with membrane-anchored Nef as bait. Wild type Nef myristoylation is replaced by the Ost4p transmembrane anchor and amino acids 39–76 of yeast ubiquitin (Cub) linked to the LexA-VP16 ...
Jessica Mötter (111471) +5 more
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Characterization of transgene expression in adenoviral vector-based HIV-1 vaccine candidates
Virology Journal, 2010 Recombinant adenovirus vectors have been extensively used in gene therapy clinical studies. More recently, the capability of inducing potent cell-mediated and humoral immunity has made these vectors equally attractive candidates for prophylactic or ...
Rolling Judith A +2 more
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The mechanism of HIV-1 Nef-mediated downregulation of CD4
, 2010 Nef, an accessory protein of HIV-1, is a critical determinant of viral pathogenicity. The pathogenic effects of Nef are in large part dependent on its ability to decrease the amount of CD4 on the surface of infected cells.
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Pathogenicity and immunogenicity of attenuated,
Retrovirology, 2007 In efforts to develop an effective vaccine, sterilizing immunity to primate lentiviruses has only been achieved by the use of live attenuated viruses carrying major deletions in nef and other accessory genes.
Wesselingh Steven L +15 more
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NEF: A Pleiotropic Modulator of Primate Lentivirus Infectivity and Pathogenesis
The lentiviral protein Nef recruits cellular signalling proteins to lipid rafts at the cell membrane and acts thereby as a master regulator affecting the transcription of a series of cellular genes.
Minarovits, J., Balog, Katalin
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, 2007 HIV-1 compartmentalization in the CNS has been demonstrated for gag, pol, and env genes. However, little is known about tissue compartmentalization of nef genes and their functional characteristics in brain.
Wei, Bangdong L. +7 more
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Functional association between the nef gene product and gag‐pol region of HIV‐1
FEBS Letters, 2000 Nef gene function is diverse among virus isolates of primate immunodeficiency viruses. We found differential effects of nef mutation on the virus replication between two HIV‐1 clones, NL432 and LAI. The nef mutation in NL432 affected the infectivity more severely compared with that in LAI, although the Nef functions of both clones were comparable ...
Ono, Takeshi +4 more
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, 1999 Deletion of the nef gene results in viral attenuation and confers protection against challenge with wild-type simian immunodeficiency virus in macaques.
Poli, Guido +21 more
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Similarities and differences between the E5 oncoproteins of bovine papillomaviruses type 1 and type 4: Cytoskeleton, motility and invasiveness in E5-transformed bovine and mouse cells [PDF]
, 2006 Bovine papillomaviruses (BPVs) are oncogenic viruses. In cattle, BPV-1/2 is associated with urinary bladder cancer and BPV-4 with upper GI tract cancer. BPV E5 is a small hydrophobic protein localised in the endoplasmic reticulum (ER) and Golgi apparatus
Ullah, R. +13 more
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