Results 121 to 130 of about 13,075 (222)

Gene expression profiling reveals Nef induced deregulation of lipid metabolism in HIV-1 infected T cells

, 2016
Human Immunodeficiency Virus-1 (HIV-1) encodes a 27 kDa Negative Factor or Nef protein, which is increasingly proving to be a misnomer. Nef seems to be crucial for AIDS progression as individuals infected with nef-deleted strain of HIV were reported to ...
Trivedi, Jay, Shrivastava, Surya, Mitra, Debashis   +2 more
core   +1 more source

Induction of AIDS in Rhesus Monkeys by a Recombinant Simian Immunodeficiency Virus Expressing nef of Human Immunodeficiency Virus Type 1

, 1999
A nef gene is present in all primate lentiviruses, including human immunodeficiency virus type 1 (HIV-1) and simian immunodeficiency virus of macaque monkeys (SIVmac).
Czajak, Susan, Howe, Anita Y. M, Desrosiers, Ronald C, Du, Zhenjian, Alexander, Louis   +4 more
core   +1 more source

[The expression of a fragment of the HIV-1 Nef gene in Escherichia coli bacteria].

Voprosy virusologii, 1991
The presence of antibodies to p27, the product of gene Nef, may be an important diagnostic sign since some sera from subjects of the risk groups negative to HIV-1 structural proteins may contain antibody to p27. The study resulted in construction of a hybrid plasmid determining in E coli bacteria the synthesis of a hybrid protein the N-terminus part of
M M, Garaev, A F, Bobkov, M Kh, Taĭ, E V, Kazennova   +3 more
openaire   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

, 1995
The Nef protein of human immunodeficiency virus type 1 (HIV-1) stimulates viral infectivity. The mechanism of this phenotype was investigated. Viruses containing disrupted nef genes were 4 to 40 times less infectious than wild-type HIV-1 in a single ...
Didier Trono, Christopher Aiken
core  

Role of nef in HIV-1 gene regulation

, 1992
Doctorat en ...
openaire   +1 more source

Characterization of Three nef -Defective Human Immunodeficiency Virus Type 1 Strains Associated with Long-Term Nonprogression

, 2000
Long-term survivors (LTS) of human immunodeficiency virus type 1 (HIV-1) infection provide an opportunity to investigate both viral and host factors that influence the rate of disease progression.
Ajantha Solomon, Nicholas Deacon, David Cooper, John Kaldor, David I. Rhodes, Andrew Carr, Lesley Ashton   +6 more
core   +1 more source

Role of genomic regions encoding non-structural proteins of human immunodeficiency virus type 1 in determining its genetic variant

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. HIV infection remains a global public health problem. One of the key elements in the system of measures aimed at controlling HIV-infection is molecular genetic surveillance.
Larisa A. Protasova, Anastasiia A. Antonova, Daria A. Ogarkova, Kristina V. Kim, Yana M. Munchak, Alexei G. Prilipov, Anna I. Kuznetsova   +6 more
doaj   +1 more source

Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators.

, 2001
Gene expression profiling was used to explore the role of Nef in HIV. Nef induces a transcriptional program in T cells that is 97% identical to that of anti-CD3 T cell activation. This program is inhibited in the presence of cyclosporin.
Simmons, Alison, McMichael, Andrew, Aluvihare, Varuna, Andrew McMichael, McMichael, A, Alison Simmons, Aluvihare, V, Varuna Aluvihare, Simmons, A   +8 more
core   +1 more source

Novel, cross-restricted, conserved, and immunodominant Cytotoxic T Lymphocyte epitopes in slow progressors in HIV Type 1 infection

, 1996
HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those ...
KARL McINTYRE, RODNEY E. PHILLIPS, Phillips, Rodney, Krausa, P, Phillips, R.E., Giangrande, P, SIOBHAN CROWLEY, Edwards, A., McIntyre, K., MIKE BUNCE, Morgan, B., Edwards, A, McMichael, A.J., Crowley, S, BARBARA MORGAN, ANNE EDWARDS, Morgan, B, Bunce, M, McMichael, Andrew, PETER KRAUSA, Crowley, S., Krausa, P., Goulder, P.J.R., Goulder, PJ, McIntyre, K, PAUL GIANGRANDE, ANDREW J. McMICHAEL, Giangrande, P., PHILIP J.R. GOULDER, McMichael, AJ, Bunce, M., Phillips, RE   +31 more
core   +1 more source