Results 111 to 120 of about 13,075 (222)

Pathogenesis of HIV-1 nef in adult mice

, 2008
Development of a suitable animal model of AIDS is much needed in AIDS research to study infection and pathogenesis as well as to evaluate methods of prevention and treatment of HIV infection.
Rahim, Mir Munir Ahmed, 1975-
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A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses.

PLoS ONE, 2011
The vaccinia virus (VACV) C6 protein has sequence similarities with the poxvirus family Pox_A46, involved in regulation of host immune responses, but its role is unknown.
Juan García-Arriaza, José Luis Nájera, Carmen E Gómez, Nolawit Tewabe, Carlos Oscar S Sorzano, Thierry Calandra, Thierry Roger, Mariano Esteban   +7 more
doaj   +1 more source

Phylogenetic Analysis of the nef Gene Reveals a Distinctive Monophyletic Clade in Korean HIV-1 Cases

Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology, 1998
To study the genetic variation of the HIV-1 strains prevalent in South Korea, we analyzed the nef sequences derived from 46 HIV-1-positive individuals living in various geographic regions in Korea. Phylogenetic analysis revealed four subtypes of HIV-1: A (3 patients), B (41 patients), D (1 patient), and a type that could not be clearly classified to ...
M R, Kang, Y K, Cho, J, Chun, Y B, Kim, I, Lee, H J, Lee, S H, Kim, Y K, Kim, K, Yoon, J M, Yang, J M, Kim, Y O, Shin, C, Kang, J S, Lee, K W, Choi, D G, Kim, W M, Fitch, S, Kim   +17 more
openaire   +3 more sources

Expression of simian immunodeficiency virus Nef protein in CD4+ T cells leads to a molecular profile of viral persistence and immune evasion

, 2006
The Nef protein of human immunodeficiency virus and simian immunodeficiency virus is expressed early in infection and plays an important role in disease progression in vivo. In addition, Nef has been shown to modulate cellular functions.
Dandekar, Satya, Thomas Ndolo, Nguyen, Hau, Ndolo, Thomas, Satya Dandekar, George, Michael, Hau Nguyen, Michael George   +7 more
core   +1 more source

Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef

Nature Communications
Innate antiviral factors are essential for effective defense against viral pathogens. However, the identity of major restriction mechanisms remains elusive.
Caterina Prelli Bozzo, Alexandre Laliberté, Aurora De Luna, Chiara Pastorio, Kerstin Regensburger, Stefan Krebs, Alexander Graf, Helmut Blum, Meta Volcic, Konstantin M. J. Sparrer, Frank Kirchhoff   +10 more
doaj   +1 more source

A study of the HIV-1 regulatory genes using the polymerase chain reaction

Вопросы вирусологии, 2015
In this work, a total of 200 samples from the HIV-infected individuals were analyzed: 50 samples from the Saha Republic (Yakutia), 50 samples from the Vologda Region (City of Cherepovets), and 100 samples from the Moscow Region (Moscow and Moscow Region).
K. A. Ryzhov, M. N. Nosik, A. V. Kravtchenko   +2 more
doaj  

Genetic analysis of human immunodeficiency virus type 1 nef in portugal: Subtyping, identification of mosaic genes, and amino acid sequence variability

, 2005
Extending our previous genetic characterization of human immunodeficiency virus type 1 (HIV-1) strains circulating in Portugal, we here report the first phylogenetic and putative amino acid sequence variability analyses of nef accessory gene.
Pádua, E., Piedade, J., Aida Esteves, Maria Teresa Paixão, Paixão, M. T., Elizabeth Pádua, Teresa Venenno, Parreira, R., Venenno, T., Esteves, A., João Piedade, Ricardo Parreira   +11 more
core   +1 more source

Improved innate and adaptive immunostimulation by genetically modified HIV-1 protein expressing NYVAC vectors.

PLoS ONE, 2011
Attenuated poxviruses are safe and capable of expressing foreign antigens. Poxviruses are applied in veterinary vaccination and explored as candidate vaccines for humans.
Esther D Quakkelaar, Anke Redeker, Elias K Haddad, Alexandre Harari, Stella Mayo McCaughey, Thomas Duhen, Abdelali Filali-Mouhim, Jean-Philippe Goulet, Nikki M Loof, Ferry Ossendorp, Beatriz Perdiguero, Paul Heinen, Carmen E Gomez, Karen V Kibler, David M Koelle, Rafick P Sékaly, Federica Sallusto, Antonio Lanzavecchia, Giuseppe Pantaleo, Mariano Esteban, Jim Tartaglia, Bertram L Jacobs, Cornelis J M Melief   +22 more
doaj   +1 more source

Expression of Nef from pSA-HNef-6His vectors with or without rare tRNA genes array.

, 2015
To evaluate the effect of the introduction of rare tRNA genes array in pSA-HNef-6His vector, the NiCo21 E. coli were individually transformed with pSA-HNef-6His, pSA-HNef-6His-RIL(CW), and pSA-HNef-6His-RIL(CCW) and Nef expression was compared with ...
Narazah Mohd Yusoff (506418), Tasyriq Che Omar (765772), Siti Aisyah Mualif (765771), Syed A. Ali (491248), Yik Wei Chew (751946), Sin-Yeang Teow (535308)   +5 more
core   +1 more source

Determining the Role of Thioredoxin in HIV-1 NEF Mediated Infectivity

, 2022
Human Immunodeficiency Virus Type 1 (HIV-1) is an opportunistic pathogen that, in the absence of treatment, leads to acquired immunodeficiency syndrome (AIDS). The success of HIV-1 persisting within hosts is primarily attributed to its genome.
Georgina Oceguera
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