Results 91 to 100 of about 1,695,057 (181)

Nef-SRC kinase interactions in HIV-1 infection of macrophages and T lymphocytes

, 2004
Nef-SRC kinase interactions in HIV-1 infection of macrophages and T ...
A Cornall (13711345), S Campbell (7641563), Johnson Mak (13082904), A Greenway (13711348)   +3 more
core  

Heterologous HIV-nef mRNA trans-splicing: a new principle how mammalian cells generate hybrid mRNA and protein molecules [PDF]

, 2001
Heterologous trans-splicing is a messenger RNA (mRNA) processing mechanism, that joins RNA segments from separate transcripts to generate functional mRNA molecules. We present here for the first time experimental evidence that the proximal segment of the
B. Berg, Graessmann, A., Berg, B., Guhl, E., L. Da Silva-Azevedo, E. Guhl, Caudevilla, C., A. Graessmann, Da Silva-Azevedo, L., Graessmann, M., M. Graessmann, C. Caudevilla   +11 more
core   +1 more source

nef-deleted HIV-1 inhibits phagocytosis by monocyte-derived macrophages in vitro but not by peripheral blood monocytes in vivo

, 2001
nef-deleted HIV-1 inhibits phagocytosis by monocyte-derived macrophages in vitro but not by peripheral blood monocytes in ...
H Chan (7732445), A Violo (13728565), J Hocking (13312737), J Mills (7665794), S Crowe (13428231), D Purcell (13728568), K Kedzierska (9863357), A Jaworowski (9684227), Johnson Mak (13082904), A Greenway (13711348), J Sullivan (9852734)   +10 more
core  

A candidate HIV/AIDS vaccine (MVA-B) lacking vaccinia virus gene C6L enhances memory HIV-1-specific T-cell responses.

PLoS ONE, 2011
The vaccinia virus (VACV) C6 protein has sequence similarities with the poxvirus family Pox_A46, involved in regulation of host immune responses, but its role is unknown.
Juan García-Arriaza, José Luis Nájera, Carmen E Gómez, Nolawit Tewabe, Carlos Oscar S Sorzano, Thierry Calandra, Thierry Roger, Mariano Esteban   +7 more
doaj   +1 more source

Zeolin–Nef accumulates to much higher amounts than zein–Nef or Nef-zein

, 2011
(A) Proteins were extracted with reducing buffer from young leaves of independent transgenic lines of tobacco expressing zeolin–Nef (lines L, N, and F), zein–Nef (16, 17, and 13), or Nef-zein (1 and 11) or from wild-type tobacco (wt). Analysis was by SDS–
Marika Rossi (52304), Eugenio Benvenuto (52305), Maddalena de Virgilio (52301), Alessandro Vitale (52307), Michele Bellucci (52302), Sergio Arcioni (52306), Davide Mainieri (52303), Francesca De Marchis (19089)   +7 more
core   +1 more source

Replication competent HIV-guided CRISPR screen identifies antiviral factors including targets of the accessory protein Nef

Nature Communications
Innate antiviral factors are essential for effective defense against viral pathogens. However, the identity of major restriction mechanisms remains elusive.
Caterina Prelli Bozzo, Alexandre Laliberté, Aurora De Luna, Chiara Pastorio, Kerstin Regensburger, Stefan Krebs, Alexander Graf, Helmut Blum, Meta Volcic, Konstantin M. J. Sparrer, Frank Kirchhoff   +10 more
doaj   +1 more source

A study of the HIV-1 regulatory genes using the polymerase chain reaction

Вопросы вирусологии, 2015
In this work, a total of 200 samples from the HIV-infected individuals were analyzed: 50 samples from the Saha Republic (Yakutia), 50 samples from the Vologda Region (City of Cherepovets), and 100 samples from the Moscow Region (Moscow and Moscow Region).
K. A. Ryzhov, M. N. Nosik, A. V. Kravtchenko   +2 more
doaj  

Nef induces multiple genes involved in cholesterol synthesis and uptake in human immunodeficiency virus type 1-infected T cells

, 2005
Several recent reports indicate that cholesterol might play an important role in human immunodeficiency virus type 1 (HIV-1) replication. We investigated the effects of HIV-1 infection on cholesterol biosynthesis and uptake using microarrays.
Kirchhoff, Frank, Swain, J. Victor, Schindler, Michael, Mullins, James I., Rao, Ushnal, Pathmajeyan, Melissa S., van 't Wout, Angélique B.   +6 more
core   +1 more source

Inhibition of the Nef regulatory protein of HIV-1 by a single-domain antibody

, 2011
The Nef protein of HIV-1 is important for AIDS pathogenesis, but it is not targeted by current antiviral strategies. Here, we describe a single-domain antibody (sdAb) that binds to HIV-1 Nef with a high affinity (K(d) = 2 × 10(-9)M) and inhibited ...
Jolicoeur, Paul, Serge Benichou, Oliver T. Fackler, Benichou, Serge, Bouchet, Jérôme, Pavel Chrobak, Basmaciogullari, Stéphane E, Chames, Patrick, Stéphane E. Basmaciogullari, Stolp, Bettina, Paul Jolicoeur, Bettina Stolp, Baty, Daniel, Fackler, Oliver T, Jérôme Bouchet, Chrobak, Pavel, Nathalie Bouchard, Daniel Baty, Bouchard, Nathalie, Patrick Chames   +19 more
core   +1 more source

The Nef protein of primate lentiviruses

The Nef protein of primate lentiviruses acts as an important virulence factor in vivo both in monkeys and in humans. Among a human cohort of long-term non-progressors, several Nef defective HIV1 viruses have been isolated, indicating that Nef may ...
Trono, Didier, Piguet, V
core   +1 more source