Results 91 to 100 of about 13,075 (222)

Characterisation of the South African HIV-1 subtype C complete 5’ LTR, nef and regulatory genes

, 2002
This article was written by Prof Janse van Rensburg before she joined the University of Pretoria.Human immunodeficiency virus type 1 (HIV-1) subtype C has become the major etiological agent in the global and especially African epidemic.
Treurnicht, Florette K., Barnett, Susan W., Zur Megede, Jan, Engelbrecht, Susan, Scriba, Thomas Jens, De Villiers, Tania, Janse van Rensburg, Estrelita   +6 more
core   +1 more source

Natural variation of the nef gene in human immunodeficiency virus type 2 infections in Portugal

Journal of General Virology, 2003
Human immunodeficiency virus type 2 (HIV-2) infections cause severe immunodeficiency in humans, although HIV-2 is associated frequently with reduced virulence and pathogenicity compared to HIV-1. Genetic determinants that play a role in HIV pathogenesis are relatively poorly understood but nef has been implicated in inducing a more pathogenic phenotype
Elizabeth, Padua, Adrian, Jenkins, Stuart, Brown, Janet, Bootman, Maria Teresa, Paixao, Neil, Almond, Neil, Berry   +6 more
openaire   +2 more sources

Bacterial Extracellular Vesicles: New Hype or Hope to Explain Reproductive Host–Microbiota Interactions

Journal of Extracellular Vesicles, Volume 15, Issue 5, May 2026.
ABSTRACT Rapid advances in microbiome research are transforming our understanding of human health and disease, with growing focus on the female reproductive tract as a critical but understudied niche. Evidence for a local microbiome largely derives from bacterial nucleic acid detection; however, the biological relevance of these signals remains debated,
Hannah Wein, Paula Iglesias‐Moreno, Apostol Apostolov, Andres Salumets, Damián O. Muzzio, Alberto Sola‐Leyva   +5 more
wiley   +1 more source

Cross-Species Transmission and Evolution of SIV Chimpanzee Progenitor Viruses Toward HIV-1 in Humanized Mice

Frontiers in Microbiology, 2020
The genetic evolution of HIV-1 from its progenitor virus SIV following cross-species transmission is not well understood. Here we simulated the SIVcpz initial transmission to humans using humanized mice and followed the viral evolution during serial ...
Kimberly Schmitt, James Curlin, Leila Remling-Mulder, Ryan Moriarty, Kelly Goff, Shelby O’Connor, Mark Stenglein, Preston Marx, Preston Marx, Ramesh Akkina   +9 more
doaj   +1 more source

A Syndecan‐Based Genetic Approach to Coat the Surface of Small Extracellular Vesicles With Nanobodies

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Small extracellular vesicles (sEVs) are promising vehicles for targeted therapeutic delivery, but strategies for their surface functionalization remain limited. Here, we present a reliable and simple genetic approach that enables customized modification of sEV surfaces and supports enhanced sEV uptake by recipient cells. This strategy is based
Lukas Hyka, Sofie Meeussen, Rania Ghossoub, Michiel De Coster, Elke De Bruyne, Guido David, Patrick Chames, Pascale Zimmermann   +7 more
wiley   +1 more source

HIV type 1 subtype C gag and nef diversity in Southern Africa.

, 2016
Several HIV-1 subtype C-specific gag- and/or nef-based vaccines are currently intended for clinical trial in southern Africa. Here we provide sequences of 64 gag and 45 nef genes sampled in Malawi, Zambia, Zimbabwe, and South Africa and assess the degree
Williamson, C, Sheppard, Haynes W, Bredell, Helba, Martin, Darren P, HIVNET028 Study Team, Gray, C, Varsani, Arvind, Van Harmelen Joanne, Donovan, R   +8 more
core   +1 more source

Discovery of 4‐Quinazolinone‐Containing Phenylalanine Derivatives as Potent, Resistant‐Tolerant HIV Capsid Inhibitors

MedComm, Volume 7, Issue 5, May 2026.
Novel phenylalanine derivatives were identified as HIV‐1 capsid inhibitors. IC‐2i showed significant anti‐HIV‐1 activity at picomolar concentrations. ABSTRACT The HIV‐1 capsid (CA) is a validated antiviral target that plays critical roles in both the early and late stages of the viral life cycle.
Xujie Zhang, Lin Sun, Laura Walsham, Yuexi Ma, Dang Ding, Mei Wang, Fabao Zhao, Jian Zhang, Zhao Wang, Shujing Xu, Xiangyi Jiang, Yang Zhou, Erik De Clercq, Christophe Pannecouque, Chin‐Ho Chen, David C. Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan   +18 more
wiley   +1 more source

Simian immunodeficiency virus Nef gene regulates the production of 2-LTR circles in vivo

Virology, 2003
The replication dynamics of simian immunodeficiency virus (SIVmac32H-C8), attenuated through discrete genetic disruption of the nef gene, were compared with the wild-type parental clone (SIVmac32H-J5) using quantitative molecular methods. The primary viraemia of both infections were similar during the first week, but peaked on Day 10 at higher levels ...
Clarke, S, Almond, N, Berry, N
openaire   +2 more sources

The Nef protein of primate lentiviruses

The Nef protein of primate lentiviruses acts as an important virulence factor in vivo both in monkeys and in humans. Among a human cohort of long-term non-progressors, several Nef defective HIV1 viruses have been isolated, indicating that Nef may ...
Trono, Didier, Piguet, V
core   +1 more source

Two Amino Acid Substitutions in the SIV Nef Protein Mediate Associations with Distinct Cellular Kinases

, 2000
A functional Nef protein is crucial in vivo for viral replication leading to pathogenesis in SIV-infected macaques. Moreover, a full-length Nef protein is required for optimal virus replication in primary cells, and both HIV and SIV Nef proteins enhance ...
Clements, Janice E., Roos, Jason W., Barber, Sheila A., Maughan, Maureen F.   +3 more
core   +1 more source