Results 61 to 70 of about 1,695,057 (181)

Deletion, insertion and stop codon mutations in vif genes of HIV-1 infecting slow progressor patients

Journal of Infection in Developing Countries, 2009
Background: Variable progression towards AIDS has been described and has been related to viral and host factors. Around 10% of the HIV-1 infected patients are slow progressors (SP), not presenting with AIDS disease signs even after more than 10 years of ...
Héctor Rafael Rangel, Domingo Garzaro, Anny Karely Rodríguez, Alvaro Hernán Ramírez, Gladys Ameli, Cristina del Rosario Gutiérrez, Flor Helene Pujol   +6 more
doaj   +1 more source

Identification of a Novel Small Molecule Facilitating HIV Elimination by the “Shock‐And‐Kill” Approach

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Antiretroviral therapy (ART) has markedly improved the prognosis of people living with HIV (PLWH); however, latent viral reservoirs remain a major barrier to a cure. The “Shock and Kill” strategy aims to reactivate latent provirus with latency‐reversing agents (LRAs) and subsequently eliminate the infected cells, yet most LRAs characterized to
Yuichiro Hara, Haruki Kitamura, Kouki Matsuda, Chieko Fujisaki, Sayaka Sukegawa, Kosuke Tanimoto, Kenji Maeda, Hiroaki Takeuchi   +7 more
wiley   +1 more source

HIV-1 Genes vpr and nef Synergistically Damage Podocytes, Leading to Glomerulosclerosis

, 2006
This study aimed to identify the causative gene for HIV-1 associated nephropathy, a paradigmatic podocytopathy. A previous study demonstrated that transgenic expression of nonstructural HIV-1 genes selectively in podocytes in mice with FVB/N genetic ...
Jianyong Zhong, Agnes B. Fogo, Li-jun Ma, Yiqin Zuo, Taiji Matsusaka, Jolicoeur, Paul, Ma, Li-jun, Hanna, Zaher, Zaher Hanna, Paul Jolicoeur, Iekuni Ichikawa, Zuo, Yiqin, Matsusaka, Taiji, Zhong, Jianyong, Ma, Ji, Ji Ma, Fogo, Agnes B, Ichikawa, Iekuni   +17 more
core   +1 more source

Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation.

PLoS Pathogens, 2017
Primate lentiviruses have evolved sophisticated strategies to suppress the immune response of their host species. For example, HIV-2 and most simian immunodeficiency viruses (SIVs) use their accessory protein Nef to prevent T cell activation and ...
Dominik Hotter, Teresa Krabbe, Elisabeth Reith, Ali Gawanbacht, Nadia Rahm, Ahidjo Ayouba, Benoît Van Driessche, Carine Van Lint, Martine Peeters, Frank Kirchhoff, Daniel Sauter   +10 more
doaj   +1 more source

Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting

MedComm, Volume 7, Issue 9, September 2026.
This review illustrates heat shock proteins (HSPs) as central regulators of cancer metabolic reprogramming. By stabilizing key metabolic enzymes and coordinating glycolysis, oxidative phosphorylation, redox homeostasis, and stress adaptation, HSPs support tumor growth, metastasis, and therapeutic resistance. Targeting HSP networks may therefore provide
Sheng Ma, Chen‐Qian Liu, Si‐Yang Ma, Shao‐Gang Wang, Qi‐Dong Xia, Meng‐Yao Xu   +5 more
wiley   +1 more source

Properties of a chimeric simian-human immunodeficiency virus expressing an hybrid HIV-1 Nef/SIVmac Nef protein

, 2002
International audienceThe nef genes of human and simian immunodeficiency viruses code for a membrane associated protein critical for AIDS development. SIVmac Nef presents C-terminal a 27 amino acid extension absent of HIV-1 Nef. To estimate the influence
Beyer, C., Gut, J., Cluet, D., Cecile, A., Bertsch, C., Gloeckler, L., Aubertin, A.   +6 more
core   +1 more source

Nef-induced differential gene expression in primary CD4+ T cells following infection with HIV-1 isolates [PDF]

, 2019
Almost 80% of viral transcripts during early HIV-1 infection encode the Nef protein, which has been implicated in altering expression of a number of genes.
Yang, Otto O, Ali, Ayub, Nixon, Douglas F, Furler, Robert L   +3 more
core   +1 more source

Graded traumatic brain injury severity differentially modulates microglial and astrocytic polarization states and response to minocycline

Neuroprotection, Volume 4, Issue 3, Page 275-294, September 2026.
Schematic diagram of the experimental design and key findings of traumatic brain injury (TBI) with varying severities. Mild, moderate, and severe TBI were induced in the right motor cortex of mice using the controlled cortical impact (CCI) method, with impact depths of 0.5, 1.0, and 2.0 mm, respectively. A subset of severe TBI mice received minocycline
Yan Yu, Chen Wang, Jinyu Zhu, Jiahui Du, Hao Li, Shuyi Ning, Rui Yang, Yiwen Ma, Mengyuan Yuan, Wei Shen, Huailin Wang, Huihui Jiang, Liping Chen, Haitao Wu   +13 more
wiley   +1 more source

Persistence of attenuated HIV-1 rev alleles in an epidemiologically linked cohort of long-term survivors infected with nef-deleted virus

Retrovirology, 2007
Background The Sydney blood bank cohort (SBBC) of long-term survivors consists of multiple individuals infected with nef-deleted, attenuated strains of human immunodeficiency virus type 1 (HIV-1).
Wesselingh Steven L, Chiavaroli Lisa, Churchill Melissa J, Gorry Paul R   +3 more
doaj   +1 more source

Focus on DnaJ protein research from Arabidopsis to crop improvement

The Plant Genome, Volume 19, Issue 3, September 2026.
Abstract DnaJ proteins (Hsp40s) are essential components of the cellular proteostasis network, functioning as molecular co‐chaperones that regulate protein folding, stability, and stress‐responsive homeostasis in plants. Beyond their classical role as Hsp70 partners, accumulating evidence demonstrates that DnaJ proteins participate in diverse ...
Muhammad Arif, Hafiz Mamoon Rehman, Sehrish Bashir, Noman Mahmood, Atul Kumar Srivastava, Yakov Kuzyakov, Moh Sajid Ansari, Hon‐Ming Lam, Mingfang Yang   +8 more
wiley   +1 more source